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1.发明申请DIASTEROSELECTIVE STRECKER SYNTHESIS OF 'alpha'-AMINOACIDS FROM GLYCOSYLAMINE DERIVATES 审中-公开谷氨酰胺衍生物中α-氨基酸的二酯选择性合成
公开(公告)号：WO1988000592A1
公开(公告)日：1988-01-28
申请号：PCT/EP1987000371
申请日：1987-07-10
Applicant: CELAMERCK GMBH & CO. KG CELAMERCK PFLANZENSCHUTZ ... , KUNZ, Horst , SAGER, Wilfried , PFRENGE, Waldemar , DECKER, Mathias
IPC: C07H13/04
CPC classification number: C07H13/04
Abstract: O-acyl-protected glycosylamines, in particular 2,3,4,6-tetra-O-pivaloyl-beta-D-galactopyranosylamine (1), their preparation and their use for the diastereoselective synthesis of alpha-aminoacids. With compounds such as (1), one can obtain by Strecker synthesis high yields and high diastereomer surplus. The direction of the asymmetric induction can be determined by the selection of the solvent. This type of synthesis is particularly effective when carried with Lewis acid catalysts. One obtains also high yields and high diastereoselectivity during Ugi four component synthesis facilitated by Lewis acids by using amines such as (1).
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