公开(公告)号：WO2010056778A1

公开(公告)日：2010-05-20

申请号：PCT/US2009/064077

申请日：2009-11-11

Applicant: SIGNUM BIOSCIENCES, INC. ,  STOCK, Jeffry, B. ,  STOCK, Maxwell ,  RAPOLE, Keshava ,  LEE, Seung-yub ,  VORONKOV, Michael ,  PEREZ, Eduardo ,  CHEN, Shuyi ,  CHEN, Jinglong ,  GORDON, Joel

Inventor： STOCK, Jeffry, B. ,  STOCK, Maxwell ,  RAPOLE, Keshava ,  LEE, Seung-yub ,  VORONKOV, Michael ,  PEREZ, Eduardo ,  CHEN, Shuyi ,  CHEN, Jinglong ,  GORDON, Joel

IPC: C07C57/02

CPC classification number: A61K31/197 ,  A61K9/0014 ,  C07C243/34 ,  C07C321/18 ,  C07C323/59 ,  C07C335/08 ,  C07C2601/02 ,  C07C2601/14 ,  C07D207/16 ,  C07D209/18 ,  C07D209/48 ,  C07D217/26 ,  C07D243/34 ,  C07D295/145 ,  C07D307/54 ,  C07D333/24

Abstract: Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses.

Abstract translation: 除此之外，本发明提供能够有效调节炎症反应的新型异戊二烯基化合物和包含这些异戊二烯基化合物的药物，化妆品，药​​妆和局部组合物。 本发明的抗炎化合物可用于治疗或预防与炎症相关的疾病或病症。 本发明的促炎症化合物可用于治疗或预防与抑制炎性反应相关的疾病或病症。 因此，本发明还提供了用于治疗或预防与炎症相关的疾病或病症的方法以及可用于治疗或预防与抑制炎性反应相关的疾病或病症的方法。