公开(公告)号：WO2003062190A1

公开(公告)日：2003-07-31

申请号：PCT/CA2003/000032

申请日：2003-01-17

申请人： THE HOSPITAL FOR SICK CHILDREN ,  ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  GRUNBERGER, Thomas ,  ROUNOVA, Olga ,  CIMPEAN, Octavian, Laurand

发明人： ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  GRUNBERGER, Thomas ,  ROUNOVA, Olga ,  CIMPEAN, Octavian, Laurand

IPC分类号： C07C255/41

CPC分类号： C07C255/41 ,  C07C317/46 ,  C07D213/71

摘要： The following compounds of formulae (I) and (III) which may be useful in treating a variety of cell proliferative disorders are disclosed: Fomula (I), (II), wherein R 1 , R 2 and R 3 are each independently selected from H, OH, C 1-6 alkyl, C 1-6 alkoxy, NH 2 , NH-C 1 -6alkyl, N(C 1-6 alkyl)(C 1-6 alkyl), SH, S-C 1-6 alkyl, NO 2 , CF 3 , OCF 3 and halo; R 4 is unsubstituted Ar, or Ar substituted with 1-4 substituents, independently selected from C 1-6 alkyl, C 1-6 alkoxy and halo; X is selected from (CH 2 CH 2 O) n and (CH 2 ) n , and n=1-4.

摘要翻译： 公开了以下可用于治疗多种细胞增殖性疾病的式（I）和（III）化合物：其中R 1，R 2和R 3各自独立地选自H，OH ，C 1-6烷基，C 1-6烷氧基，NH 2，NH-C 1-6烷基，N（C 1-6烷基）（C 1-6烷基），SH，S-C 1-6烷基，NO 2，CF 3，OCF 3和卤素; R4是未取代的Ar或被1-4个取代基取代的Ar，其独立地选自C 1-6烷基，C 1-6烷氧基和卤素; X选自（CH 2 CH 2 O）n和（CH 2）n，n = 1-4。

公开(公告)号：WO2005012234A1

公开(公告)日：2005-02-10

申请号：PCT/CA2004/001431

申请日：2004-07-30

申请人： THE HOSPITAL FOR SICK CHILDREN ,  ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  ROUNOVA, Olga ,  GRUNBERGER, Thomas ,  CIMPEAN, Octavian, Laurand

发明人： ROIFMAN, Chaim, M. ,  DEMIN, Peter ,  ROUNOVA, Olga ,  GRUNBERGER, Thomas ,  CIMPEAN, Octavian, Laurand

IPC分类号： C07C255/41

CPC分类号： A61K31/4402 ,  C07C255/41 ,  C07C323/46 ,  C07D213/71

摘要： Compounds having the Formula (I) or (III) wherein R 1 , R 2 and R 3 are each independently selected from H, OH, C 1-6 alkyl, C 1-6 alkoxy, NH 2 , NH-(C l-6 a1kyl), N(C 1-6 a1kyl)(C 1-6 alkyl), SH, S-C 1-6 alkyl, NO 2 , CF 3 , OCF 3 , and halo; R 4 is unsubstituted Ar or Ar substituted with 1-4 substituents independently selected from C 1-6 alkyl, C 1-6 alkoxy and halo; X is selected from (CH 2 CH 2 O)n and (CH)n, and n = 1-4, salts, solvates and hydrates thereof, useful for modulating or inhibiting cell proliferation, are described.

摘要翻译： 具有式（I）或（III）的化合物其中R 1，R 2和R 3各自独立地选自H，OH，C 1-6烷基，C 1-6烷氧基，NH 2，NH-（Cl- C 1-6烷基），N（C 1-6烷基）（C 1-6烷基），SH，S-C 1-6烷基，NO 2，CF 3，OCF 3和卤素; R 4是未取代的Ar或Ar，其被1-4个独立地选自C 1-6烷基，C 1-6烷氧基和卤素的取代基取代; 描述了可用于调节或抑制细胞增殖的（CH 2 CH 2 O）n和（CH）n和n = 1-4，其盐，溶剂合物和水合物。