公开(公告)号：WO2004110983A3

公开(公告)日：2004-12-23

申请号：PCT/EP2004/006330

申请日：2004-06-11

Applicant: LABORATORIOS S.A.L.V.A.T., S.A. ,  FERNÁNDEZ SERRAT, Anna ,  SERRA COMAS, Carme ,  BALSA LÓPEZ, Dolors ,  LLEBARIA SOLDEVILA, Amadeu ,  FARRERONS GALLEMI, Carles ,  MIQUEL BONO, Ignacio José ,  CATENA RUIZ, Juan Lorenzo ,  LAGUNAS ARNAL, Carmen ,  CORDOMÍ MONTOYA, Arnau ,  SALCEDO ROCA, Carolina ,  TOLEDO MESA, Natividad ,  MARRERO GONZÁLEZ, Pedro ,  HARO BAUTISTA, Diego ,  FERNÁNDEZ GARCÍA, Andrés

Inventor： FERNÁNDEZ SERRAT, Anna ,  SERRA COMAS, Carme ,  BALSA LÓPEZ, Dolors ,  LLEBARIA SOLDEVILA, Amadeu ,  FARRERONS GALLEMI, Carles ,  MIQUEL BONO, Ignacio José ,  CATENA RUIZ, Juan Lorenzo ,  LAGUNAS ARNAL, Carmen ,  CORDOMÍ MONTOYA, Arnau ,  SALCEDO ROCA, Carolina ,  TOLEDO MESA, Natividad ,  MARRERO GONZÁLEZ, Pedro ,  HARO BAUTISTA, Diego ,  FERNÁNDEZ GARCÍA, Andrés

IPC: C07C235/52

Abstract: Compounds of general structure (I), wherein the central benzene ring may be substituted in the meta- or para-­position; -A is an optionally substituted hydroxyl, alkoxyl, hydroxylamine, alkoxylamine or amine radical; -W is an N- ­and C-linked biradical selected from several possibilities; and -Z is a carbon radical selected from several possibilities. These compounds are PPARϒ and PPARϒ/ PPARδ modulators and, therefore, are useful for the prophylactic and/or curative treatment of a condition or a disease mediated by these recetpcors.