公开(公告)号：WO2014138606A2

公开(公告)日：2014-09-12

申请号：PCT/US2014/021836

申请日：2014-03-07

Applicant: CRYOMEDIC TECHNOLOGIES LLC

Inventor： WALTER, William

IPC: A01N1/02

CPC classification number: A01N1/0268 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284 ,  A61J1/10 ,  A61M1/025 ,  A61M1/0272 ,  A61M2205/366

Abstract: One aspect of the present disclosure relates to a bag for storing blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the blood is caused to flow.

Abstract translation: 本公开的一个方面涉及一种用于存储先前从受试者撤回的血液的袋。 该袋可以包括柔性密封容器和粘附到容器的外表面部分上的至少一个可拆卸热传递构件。 容器可以包括形成容器的一部分的入口。 该入口可适于流体密封地连接到通过血液流过的管构件。

公开(公告)号：WO2014138566A3

公开(公告)日：2015-01-08

申请号：PCT/US2014021690

申请日：2014-03-07

Applicant: CRYOMEDIC TECHNOLOGIES LLC

Inventor： WALTER WILLIAM ,  WALKER JIMMY

IPC: A01N1/02 ,  A61M1/02

CPC classification number: A01N1/0268 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284 ,  A61J1/10 ,  A61J1/1487 ,  A61J2200/42 ,  A61J2200/44 ,  A61M1/025 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/36

Abstract: One aspect of the present disclosure relates to a bag (10) for storing platelets or contaminated blood previously withdrawn from a subject. The bag comprises a flexible, closed container (12) and at least one removable heat transfer member (24). The container includes an inlet (14) adapted for fluid-tight connection to a tube member (16). A further aspect of the disclosure relates to a system for freezing or thawing platelets or contaminated blood, which comprises an agitator drive; a linkage arm operably connected to the agitator drive, the linkage arm configured to translate a rotary motion generated by the agitator drive to an angular reciprocation motion; a reciprocating arm operably connected to the linkage arm; and a container configured to hold the blood and being operably connected to a distal end of the reciprocating arm. Operation of the system provides a wrist-action motion to the container and thereby minimizes the amount of red blood cell (RBC) and platelet lysis caused by freezing or thawing.

Abstract translation: 本公开的一个方面涉及一种用于存储先前从受试者撤回的血小板或污染的血液的袋（10）。 该袋包括柔性封闭容器（12）和至少一个可拆卸传热构件（24）。 容器包括适于与管构件（16）流体密封连接的入口（14）。 本公开的另一方面涉及用于冷冻或解冻血小板或污染血液的系统，其包括搅拌器驱动; 连杆臂可操作地连接到搅拌器驱动器，所述连杆臂构造成将由搅拌器驱动产生的旋转运动转换成角度往复运动; 可操作地连接到所述连杆臂的往复臂; 以及构造成保持血液并且可操作地连接到往复臂的远端的容器。 该系统的操作为容器提供了手腕动作，从而使红细胞（RBC）的量和冻结或解冻引起的血小板裂解最小化。

公开(公告)号：WO2014138606A3

公开(公告)日：2014-12-31

申请号：PCT/US2014021836

申请日：2014-03-07

Applicant: CRYOMEDIC TECHNOLOGIES LLC

Inventor： WALTER WILLIAM

IPC: A01N1/02 ,  A61M1/02

CPC classification number: A01N1/0268 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284 ,  A61J1/10 ,  A61M1/025 ,  A61M1/0272 ,  A61M2205/366

Abstract: One aspect of the present disclosure relates to a bag (10) for storing blood previously withdrawn from a subject. The bag comprises a flexible, closed container (12) and at least one removable heat transfer member (24) adhered to an outer surface portion (26) of the container. The container can include an inlet (14) adapted for fluid-tight connection to a tube member (16) through which blood can flow. A further aspect of the disclosure relates to a system for freezing or thawing blood, which comprises an agitator drive; a linkage arm operably connected to the agitator drive, the linkage arm configured to translate a rotary motion generated by the agitator drive to an angular reciprocation motion; a reciprocating arm operably connected to the linkage arm; and a container configured to hold the blood and being operably connected to a distal end of the reciprocating arm. Operation of the system provides a wrist-action motion to the container and thereby minimizes the amount of red blood cell (RBC) hemolysis caused by freezing or thawing.

Abstract translation: 本公开的一个方面涉及一种用于存储先前从受试者撤回的血液的袋（10）。 所述袋包括柔性密封容器（12）和粘附到所述容器的外表面部分（26）上的至少一个可移除热传递构件（24）。 容器可以包括适于与血管可流动的管构件（16）的流体密封连接的入口（14）。 本公开的另一方面涉及一种用于冷冻或解冻血液的系统，其包括搅拌器驱动; 连杆臂可操作地连接到搅拌器驱动器，所述连杆臂构造成将由搅拌器驱动产生的旋转运动转换成角度往复运动; 可操作地连接到所述连杆臂的往复臂; 以及构造成保持血液并且可操作地连接到往复臂的远端的容器。 系统的操作为容器提供了一个手腕动作，从而使由冻结或解冻引起的红细胞溶血量（RBC）最小化。

公开(公告)号：WO2014138566A2

公开(公告)日：2014-09-12

申请号：PCT/US2014/021690

申请日：2014-03-07

Applicant: CRYOMEDIC TECHNOLOGIES LLC

Inventor： WALTER, William ,  WALKER, Jimmy

IPC: A01N1/02

CPC classification number: A01N1/0268 ,  A01N1/0242 ,  A01N1/0263 ,  A01N1/0284 ,  A61J1/10 ,  A61J1/1487 ,  A61J2200/42 ,  A61J2200/44 ,  A61M1/025 ,  A61M1/0272 ,  A61M1/0281 ,  A61M1/36

Abstract: One aspect of the present disclosure relates to a bag for storing platelets or contaminated blood previously withdrawn from a subject. The bag can comprise a flexible, closed container and at least one removable heat transfer member adhered to an outer surface portion of the container. The container can include an inlet therein that forms part of the container. The inlet can be adapted for fluid-tight connection to a tube member through which the platelets or contaminated blood are caused to flow.

Abstract translation: 本公开的一个方面涉及一种用于存储先前从受试者撤回的血小板或污染的血液的袋。 该袋可以包括柔性密封容器和粘附到容器的外表面部分上的至少一个可移除的传热构件。 容器可以包括形成容器的一部分的入口。 入口可以适于与管构件流体密封连接，通过该管构件使血小板或污染的血液流动。