公开(公告)号：WO2003035673A1

公开(公告)日：2003-05-01

申请号：PCT/EP2002/011761

申请日：2002-10-21

Applicant: DOMPE S.P.A. ,  GENTILE, Marco ,  DI PALMA, Cesare ,  CESTA, Maria, Candida

Inventor： GENTILE, Marco ,  DI PALMA, Cesare ,  CESTA, Maria, Candida

IPC: C07K1/32

CPC classification number: C07K1/30 ,  Y02P20/544

Abstract: A process for the co-precipitation of a substance with a stabiliser therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel (22) and a nozzle (27) having a central orifice (39) serving to introduce a solution of the substance and a plurality of outer orifices (41) serving to carry a flow of supercritical fluid into the particle formation vessel (22), such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs. The substance is preferably a protein of pharmaceutical interest, which is highly stabilized for storage by this process.

Abstract translation: 通过气体反溶剂法将物质与其稳定剂共沉淀的方法包括将纯的或与改性剂混合的超临界流体引入颗粒形成容器中; 和包含所述物质和所述稳定剂溶于溶剂中的溶液; 因为所述溶剂是通过所述超临界流体从溶液中提取的，并且发生物质和稳定剂的共沉淀。 该方法可以使用包括颗粒形成容器（22）和具有用于引入物质溶液的中心孔（39）和用于携带的多个外孔（41）的喷嘴（27）的装置来进行 将超临界流体流入颗粒形成容器（22），使得通过超临界流体从溶液中提取溶剂，并发生物质/稳定剂的微米级颗粒的沉淀。 该物质优选是药物感兴趣的蛋白质，其通过该方法高度稳定以储存。

公开(公告)号：WO02068107A8

公开(公告)日：2003-10-16

申请号：PCT/GB0200840

申请日：2002-02-26

Applicant: DOMPE SPA ,  DEL RE GIOVANNI ,  PUTRIGNANO MATTEO ,  DI GIACOMO GABRIELE ,  DI PALMA CESARE ,  PIESOLD ALEXANDER JAMES

Inventor： DEL RE GIOVANNI ,  PUTRIGNANO MATTEO ,  DI GIACOMO GABRIELE ,  DI PALMA CESARE

IPC: C12M1/00 ,  A61L2/07 ,  B01D9/02 ,  B01J2/04 ,  B01J3/00 ,  B01J7/00 ,  B05B7/08 ,  C12N9/00

CPC classification number: B05B7/08 ,  B01J2/04

Abstract: An apparatus is described for micron and submicron particles formation of a substance using the GAS process, comprising a particles formation vessel (22) and means for introducing a solution of the substance and a supercritical fluid into the particles formation vessel (22), wherein said means comprise a nozzle (27) having a central orifice (39) serving to carry a flow of solution, and a plurality of separate outer orifices (41) serving to carry a flow of pure supercritical fluid or a flow of supercritical fluid mixed with a modifier, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron and submicron particles occurs. Also a process is described, carried out with such an apparatus.

Abstract translation: 描述了使用GAS方法形成物质的微米和亚微米颗粒的装置，其包括颗粒形成容器（22）和用于将物质和超临界流体的溶液引入到颗粒形成容器（22）中的装置，其中所述 装置包括具有用于承载溶液流的中心孔口（39）的喷嘴（27）和用于承载纯超临界流体流或混合有超临界流体的超临界流体流的多个分开的外部孔口（41） 使得通过超临界流体从溶液中提取溶剂并发生微米和亚微米颗粒的沉淀。 还描述了使用这种装置进行的过程。

公开(公告)号：WO02068107A3

公开(公告)日：2002-12-05

申请号：PCT/GB0200840

申请日：2002-02-26

Applicant: DOMPE SPA ,  DEL RE GIOVANNI ,  PUTRIGNANO MATTEO ,  DI GIACOMO GABRIELE ,  DI PALMA CESARE ,  PIESOLD ALEXANDER JAMES

Inventor： DEL RE GIOVANNI ,  PUTRIGNANO MATTEO ,  DI GIACOMO GABRIELE ,  DI PALMA CESARE

IPC: C12M1/00 ,  A61L2/07 ,  B01D9/02 ,  B01J2/04 ,  B01J3/00 ,  B01J7/00 ,  B05B7/08 ,  C12N9/00

CPC classification number: B05B7/08 ,  B01J2/04

Abstract: An apparatus is described for micron and submicron particles formation of a substance using the GAS process, comprising a particles formation vessel (22) and means for introducing a solution of the substance and a supercritical fluid into the particles formation vessel (22), wherein said means comprise a nozzle (27) having a central orifice (39) serving to carry a flow of solution, and a plurality of separate outer orifices (41) serving to carry a flow of pure supercritical fluid or a flow of supercritical fluid mixed with a modifier, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron and submicron particles occurs. Also a process is described, carried out with such an apparatus.

Abstract translation: 描述了使用GAS方法形成物质的微米和亚微米颗粒的装置，其包括颗粒形成容器（22）和用于将物质和超临界流体的溶液引入到颗粒形成容器（22）中的装置，其中所述 装置包括具有用于承载溶液流的中心孔口（39）的喷嘴（27）和用于承载纯超临界流体流或混合有超临界流体的超临界流体流的多个分开的外部孔口（41） 使得通过超临界流体从溶液中提取溶剂并发生微米和亚微米颗粒的沉淀。 还描述了使用这种装置进行的过程。

公开(公告)号：WO03035673A9

公开(公告)日：2003-11-13

申请号：PCT/EP0211761

申请日：2002-10-21

Applicant: DOMPE SPA ,  GENTILE MARCO ,  DI PALMA CESARE ,  CESTA MARIA CANDIDA

Inventor： GENTILE MARCO ,  DI PALMA CESARE ,  CESTA MARIA CANDIDA

IPC: C12N9/96 ,  C07K1/30 ,  C07K1/32

CPC classification number: C07K1/30 ,  Y02P20/544

Abstract: A process for the co-precipitation of a substance with a stabiliser therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabiliser dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabiliser occurs. The process may be carried out using an apparatus comprising a particle formation vessel (22) and a nozzle (27) having a central orifice (39) serving to introduce a solution of the substance and a plurality of outer orifices (41) serving to carry a flow of supercritical fluid into the particle formation vessel (22), such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs. The substance is preferably a protein of pharmaceutical interest, which is highly stabilized for storage by this process.

Abstract translation: 一种通过气体反溶剂方法使物质与稳定剂共沉淀的方法，该方法包括向颗粒形成容器中引入纯净的或与改性剂混合的超临界流体; 以及包含溶解在溶剂中的所述物质和所述稳定剂的溶液; 从而通过所述超临界流体从溶液中提取所述溶剂并且发生物质和稳定剂的共沉淀。 该过程可以使用包括颗粒形成容器（22）和喷嘴（27）的装置来实施，所述喷嘴具有用于引入所述物质的溶液的中心孔口（39）和用于承载所述物质的多个外部孔口（41） 超临界流体流入颗粒形成容器（22）中，使得通过超临界流体从溶液中提取溶剂并且发生物质/稳定剂的微米尺寸颗粒的沉淀。 该物质优选是药物感兴趣的蛋白质，其通过该过程高度稳定以用于储存。

公开(公告)号：WO2002068107A2

公开(公告)日：2002-09-06

申请号：PCT/GB2002/000840

申请日：2002-02-26

Applicant: DOMPE S.P.A. ,  PIESOLD, Alexander, James ,  DEL RE, Giovanni ,  PUTRIGNANO, Matteo ,  DI GIACOMO, Gabriele ,  DI PALMA, Cesare

Inventor： DEL RE, Giovanni ,  PUTRIGNANO, Matteo ,  DI GIACOMO, Gabriele ,  DI PALMA, Cesare

IPC: B01J

CPC classification number: B05B7/08 ,  B01J2/04

Abstract: An apparatus is described for micron and submicron particles formation of a substance using the GAS process, comprising a particles formation vessel (22) and means for introducing a solution of the substance and a supercritical fluid into the particles formation vessel (22), wherein said means comprise a nozzle (27) having a central orifice (39) serving to carry a flow of solution, and a plurality of separate outer orifices (41) serving to carry a flow of pure supercritical fluid or a flow of supercritical fluid mixed with a modifier, such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron and submicron particles occurs. Also a process is described, carried out with such an apparatus.

Abstract translation: 描述了一种使用GAS方法用于微米和亚微米颗粒物质形成的装置，包括颗粒形成容器（22）和用于将物质和超临界流体的溶液引入颗粒形成容器 （22），其中所述装置包括具有用于承载溶液流的中心孔（39）的喷嘴（27）和用于承载纯超临界流体流的多个分开的外孔（41），或者 与改性剂混合的超临界流体流，使得超临界流体从溶液中提取溶剂并且发生微米和亚微米颗粒的沉淀。 还描述了用这样的设备进行的过程。