公开(公告)号：WO2009014534A1

公开(公告)日：2009-01-29

申请号：PCT/US2007/073957

申请日：2007-07-20

Applicant: ABBOTT GMBH & CO. KG ,  LIU ,  ROSENBERG, Joerg ,  WOEHRLE, Gerd ,  KESSLER, Thomas Y. ,  BREITENBACH, Joerg ,  DURAK, Salih ,  RICHTER, Friedrich W. ,  DUTTA, Sandeep

Inventor： ROSENBERG, Joerg ,  WOEHRLE, Gerd ,  KESSLER, Thomas Y. ,  BREITENBACH, Joerg ,  DURAK, Salih ,  RICHTER, Friedrich W. ,  DUTTA, Sandeep

IPC: A61K9/28 ,  A61K31/00

CPC classification number: A61K9/284 ,  A61K9/2853 ,  A61K9/2866 ,  A61K31/167 ,  A61K31/485 ,  A61K2300/00

Abstract: The preferred exemplary embodiments in the present application provide formulations and methods for the delivery of drugs, particularly drugs of abuse, having an abuse-relevant drug substantially confined in the core and a non-abuse relevant drug in a non-core region. These formulations have reduced potential for abuse. In the formulation, preferably the abuse relevant drug is an opioid and the non-abuse relevant drug is acetaminophen or ibuprofen. More preferably, the opioid is hydrocodone, and the non-abuse relevant analgesic is acetaminophen. In certain preferred embodiments, the dosage forms are characterized by resistance to solvent extraction; tampering, crushing or grinding. Certain embodiments of the inventions provide dosage forms that provide an initial burst of release of drug followed by a prolonged period of controllable drug release.

Abstract translation: 本申请中优选的示例性实施方案提供用于递送药物，特别是滥用药物，具有基本上限于核心的滥用相关药物和非核心区域中的非滥用相关药物的制剂和方法。 这些制剂减少了滥用的可能性。 在制剂中，优选滥用相关药物是阿片样物质，非滥用相关药物是对乙酰氨基酚或布洛芬。 更优选地，阿片样物质是氢可酮，非滥用相关镇痛药是对乙酰氨基酚。 在某些优选的实施方案中，剂型的特征在于耐溶剂萃取; 篡改，破碎或研磨。 本发明的某些实施方案提供剂型，其提供药物释放的初始爆发，随后延长药物释放时间。