公开(公告)号：WO2022170084A1

公开(公告)日：2022-08-11

申请号：PCT/US2022/015296

申请日：2022-02-04

Applicant: BECKMAN COULTER, INC. ,  MONSONIS, Frederic ,  SAN, Boi, Hoa ,  EASWARAN, Arunkumar ,  TOMASULO, Massimiliano ,  GULNIK, Sergei ,  VENKATESH, Rajesh ,  SRINIVASAN, Shiva, Ranjini

Inventor： MONSONIS, Frederic ,  SAN, Boi, Hoa ,  EASWARAN, Arunkumar ,  TOMASULO, Massimiliano ,  GULNIK, Sergei ,  VENKATESH, Rajesh ,  SRINIVASAN, Shiva, Ranjini

IPC: G01N33/533 ,  G01N33/53

Abstract: The disclosure relates to compositions comprising a non-fluorescent component of a polymer dye such as a monomeric component of a polymer dye, a photo-bleached polymer dye, and/or a polymer dye comprising a quenching moiety, for reducing non-specific interactions of polymer dye conjugates, for example, in Flow Cytometric Analysis of a biological sample. Methods for using such compositions, and kits comprising such compositions are also provided.

公开(公告)号：WO2011059457A1

公开(公告)日：2011-05-19

申请号：PCT/US2009/064621

申请日：2009-11-16

Applicant: UNIVERSITY OF NOTRE DAME DU LAC ,  MOLECULAR TARGETING TECHNOLOGIES, INC. ,  SMITH, Bradley ,  EASWARAN, Arunkumar

Inventor： SMITH, Bradley ,  EASWARAN, Arunkumar

IPC: C09B62/006 ,  H01L27/32 ,  H01L51/54

CPC classification number: C09B57/00 ,  C09B57/007 ,  G01N2458/30

Abstract: Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to novel near-infrared dyes that are photostable and resistant to quenching. The dyes belong to a novel family of squaraine rotaxanes, and they are particularly well-suited for use in biological applications. Also disclosed are methods of synthesizing the dyes and methods of using the dyes.

Abstract translation: 实施方案涉及化学和生物化学领域，更具体地涉及光稳定并且耐淬火的新型近红外染料。 这些染料属于一种新型的方酸酯轮烷系列，它们特别适用于生物应用。 还公开了合成染料的方法和使用染料的方法。