公开(公告)号：WO2022189442A1

公开(公告)日：2022-09-15

申请号：PCT/EP2022/055919

申请日：2022-03-08

申请人： EM SCIENTIFIC LIMITED

发明人： SIRKA, Ernestas ,  CRYAR, Adam

IPC分类号： G01N33/68 ,  G01N2800/2835 ,  G01N2800/52 ,  G01N33/6848 ,  G01N33/6896

摘要： The present invention relates to a method for assessing the efficacy a treatment for a neurodegenerative disease in a subject wherein the presence of said proteolytic peptide is assayed for using mass spectrometry with reference to a corresponding labelled and/or unlabelled reference proteolytic peptide. The invention also relates to a method for stratifying a subject having a neurodegenerative disease, a method for the diagnosis of a neurodegenerative disease, methods for the treatment of a subject having a neurodegenerative disease and a kit for assessing the efficacy of a first-line treatment for a neurodegenerative disease in a subject.