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公开(公告)号：WO2012061227A3
公开(公告)日：2012-08-23
申请号：PCT/US2011058257
申请日：2011-10-28
Applicant: 3M INNOVATIVE PROPERTIES CO , CHANDRAPATI SAILAJA , WEBB HEATHER M , PEDERSON JEFFREY C , SMITH JEFFREY D , DUDA RUTHANN R , ENGEL BRIAN J
Inventor： CHANDRAPATI SAILAJA , WEBB HEATHER M , PEDERSON JEFFREY C , SMITH JEFFREY D , DUDA RUTHANN R , ENGEL BRIAN J
IPC: C12Q1/22
Abstract: A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
Abstract translation: 生物灭菌指示剂（BI）。 BI可以包括壳体和位于壳体中的容器。 容器可以容纳液体，容器的至少一部分可以是易碎的。 BI还可以包括第一室和第二室。 第二室可包括至少一种生物活性来源。 BI还可以包括位于第一室和第二室之间的壳体中的基板。 衬底可以定位成与第一腔室和第二腔室流体连通，并且衬底可以进一步定位成使得衬底不与生物活性源直接接触。
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公开(公告)号：WO2012061227A2
公开(公告)日：2012-05-10
申请号：PCT/US2011/058257
申请日：2011-10-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , SMITH, Jeffrey D. , DUDA, RuthAnn R. , ENGEL, Brian J.
Inventor： CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , SMITH, Jeffrey D. , DUDA, RuthAnn R. , ENGEL, Brian J.
IPC: C12Q1/22
Abstract: A biological sterilization indicator (BI). The BI can include a housing, and a container positioned in the housing. The container can contain a liquid and at least a portion of the container can be frangible. The BI can further include a first chamber and a second chamber. The second chamber can include at least one source of biological activity. The BI can further include a substrate positioned in the housing between the first chamber and the second chamber. The substrate can be positioned in fluid communication with the first chamber and the second chamber, and the substrate can be further positioned such that the substrate is not in direct contact with the source of biological activity.
Abstract translation: 生物灭菌指示器（BI）。 BI可以包括壳体和位于壳体中的容器。 容器可以容纳液体并且容器的至少一部分可以是易碎的。 BI还可以包括第一腔室和第二腔室。 第二室可以包括至少一种生物活性来源。 BI还可以包括位于第一腔室和第二腔室之间的壳体中的基板。 衬底可以定位成与第一室和第二室流体连通，并且衬底可以进一步定位成使得衬底不直接与生物活性源接触。
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公开(公告)号：WO2012061213A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058212
申请日：2011-10-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja, , WEBB, Heather M., , PEDERSON, Jeffrey C., , HALVERSON, Kurt J., , ENGEL, Brian J.,
Inventor： CHANDRAPATI, Sailaja, , WEBB, Heather M., , PEDERSON, Jeffrey C., , HALVERSON, Kurt J., , ENGEL, Brian J.,
IPC: C12Q1/22
Abstract: The present invention provides method of detecting a predetermined biological activity. The method includes using an aqueous mixture comprising a first indicator reagent with a first absorption spectrum and a second indicator reagent. The second indicator reagent is converted by the predetermined biological activity to a second biological derivative with a second emission spectrum. The first absorbance spectrum includes detectable absorbance in at least a portion of wavelengths present in the second emission spectrum. The first indicator reagent is received and concentrated from an aqueous liquid by a substrate, facilitating the detection of the second biological derivative.
Abstract translation: 本发明提供了检测预定生物活性的方法。 该方法包括使用包含具有第一吸收光谱的第一指示剂和第二指示剂试剂的含水混合物。 第二指示剂通过预定的生物活性转化为具有第二发射光谱的第二生物衍生物。 第一吸收光谱包括在第二发射光谱中存在的波长的至少一部分中的可检测吸光度。 第一指示剂被含水液体接收并通过底物浓缩，便于检测第二生物衍生物。
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公开(公告)号：WO2012061212A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/058210
申请日：2011-10-28
Applicant: 3M INNOVATIVE PROPERTIES COMPANY , CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , ENGEL, Brian J.
Inventor： CHANDRAPATI, Sailaja , WEBB, Heather M. , PEDERSON, Jeffrey C. , ENGEL, Brian J.
IPC: C12Q1/22
Abstract: A method of detecting a biological activity is provided. The method includes contacting; in a liquid medium selected to facilitate a predetermined biological activity; a sample, an indicator reagent, and a substrate that receives and concentrates a biological derivative of the indicator reagent. The method further includes observing a portion of the substrate to detect the biological derivative. The method can be used to detect the presence or absence of a target cell.
Abstract translation: 提供了检测生物活性的方法。 该方法包括接触; 在选择用于促进预定生物活性的液体介质中; 样品，指示剂试剂和接收并浓缩指示剂试剂的生物衍生物的底物。 该方法还包括观察基底的一部分以检测生物衍生物。 该方法可用于检测靶细胞的存在或不存在。
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