公开(公告)号：WO2010106169A1

公开(公告)日：2010-09-23

申请号：PCT/EP2010/053619

申请日：2010-03-19

Applicant: GENERAL ELECTRIC COMPANY ,  GE HEALTHCARE LIMITED ,  CARTER, Randall, Lee ,  CASTLE, Jason, William ,  FISH, Kenneth, Michael ,  SOOD, Anup ,  STAPLES, Natalie, Anne ,  LEE, Brian Duh-lan

Inventor： CARTER, Randall, Lee ,  CASTLE, Jason, William ,  FISH, Kenneth, Michael ,  SOOD, Anup ,  STAPLES, Natalie, Anne ,  LEE, Brian Duh-lan

IPC: A61K49/00

CPC classification number: A61K49/0032 ,  A61K49/0054

Abstract: The present invention relates to a method of in vivo optical imaging, of the margins around tumours, which comprises an optical imaging contrast agent. The optical imaging agents comprise conjugates of near-infrared dyes with synthetic polyethyleneglycol (PEG) polymers having a molecular weight in the range 15-45 kDa. Also disclosed are optical imaging contrast agents, pharmaceutical compositions and kits.

Abstract translation: 本发明涉及一种体内光学成像方法，包括光学成像造影剂，包括肿瘤周围的边缘。 光学成像剂包括近红外染料与分子量在15-45kDa范围内的合成聚乙二醇（PEG）聚合物的共轭物。 还公开了光学成像造影剂，药物组合物和试剂盒。

公开(公告)号：WO2010141704A3

公开(公告)日：2010-12-09

申请号：PCT/US2010/037237

申请日：2010-06-03

Applicant: GENERAL ELECTRIC COMPANY ,  TAN HEHIR, Cristina, Abucay ,  SICLOVAN, Tiberiu, Mircea ,  BARNHARDT, Nicole, Evelyn ,  FISH, Kenneth, Michael ,  CARTER, Randall, Lee ,  JOHNSON, Bruce, Fletcher ,  ZHANG, Rong

Inventor： TAN HEHIR, Cristina, Abucay ,  SICLOVAN, Tiberiu, Mircea ,  BARNHARDT, Nicole, Evelyn ,  FISH, Kenneth, Michael ,  CARTER, Randall, Lee ,  JOHNSON, Bruce, Fletcher ,  ZHANG, Rong

IPC: A61K49/10

Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.

公开(公告)号：WO2010141704A2

公开(公告)日：2010-12-09

申请号：PCT/US2010037237

申请日：2010-06-03

Applicant: GEN ELECTRIC ,  TAN HEHIR CRISTINA ABUCAY ,  SICLOVAN TIBERIU MIRCEA ,  BARNHARDT NICOLE EVELYN ,  FISH KENNETH MICHAEL ,  CARTER RANDALL LEE ,  JOHNSON BRUCE FLETCHER ,  ZHANG RONG

Inventor： TAN HEHIR CRISTINA ABUCAY ,  SICLOVAN TIBERIU MIRCEA ,  BARNHARDT NICOLE EVELYN ,  FISH KENNETH MICHAEL ,  CARTER RANDALL LEE ,  JOHNSON BRUCE FLETCHER ,  ZHANG RONG

IPC: A61K49/10

CPC classification number: A61K49/10

Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.

Abstract translation: 本发明涉及髓鞘碱性蛋白检测的方法，包括鉴定患有髓磷脂相关神经病的风险或被诊断的受试者，通过胃肠外给药该试剂，以及通过检测与髓磷脂碱性蛋白的结合来测定受试者的髓鞘形成。 还提供了检测髓磷脂的方法以及使用特异性结合髓磷脂碱性蛋白的药剂对样品中局部浓度的定量测量，其中包含用于检测髓磷脂碱性蛋白质的试剂或其衍生物的试剂盒。