公开(公告)号：WO2021063972A1

公开(公告)日：2021-04-08

申请号：PCT/EP2020/077272

申请日：2020-09-29

Applicant: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) ,  FUNDACIÓ INSTITUT MAR D'INVESTIGACIONS MÈDIQUES (FIMIM) ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： CALON, Alexandre ,  IGLESIAS COMA, Mar ,  BATLLE GÓMEZ, Eduard ,  SANCHO SUILS, Elena ,  BERENGUER LLERGO, Antonio

IPC: G01N33/574 ,  C12Q1/6886

Abstract: The present invention relates to a new biomarker useful to identify cancer patients with a TGFβ-activated microenvironment in colorectal cancer and other tumor types. It further relates to methods of predicting response to inhibitors of the TGFβ signaling pathway and methods of classification and selection of cancer patients for treatment with inhibitors of the TGFβ signaling pathway, to prognostic methods, to methods of monitoring or evaluating response to inhibitors of the TGFβ signaling pathway and to related second medical uses, diagnostic kits and uses thereof.