公开(公告)号：WO2014008038A1

公开(公告)日：2014-01-09

申请号：PCT/US2013/047563

申请日：2013-06-25

Applicant: ROBERT BOSCH GMBH ,  KAVUSI, Sam ,  GANGADHARAN, Rajan ,  JOHNSON, Christopher ,  LAU, Aldrich, N.K. ,  VERMA, Piyush

Inventor： KAVUSI, Sam ,  GANGADHARAN, Rajan ,  JOHNSON, Christopher ,  LAU, Aldrich, N.K. ,  VERMA, Piyush

IPC: G01N33/50 ,  G01N33/53

CPC classification number: G01N33/50 ,  G01N27/3275 ,  G01N33/5306

Abstract: Methods of modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest from a biological sample in a biosensor having a multisite array of test sites. In particular, the methods modulate the pH or ionic concentration gradient near the electrodes in such biosensor. The methods of modulating the binding interactions provide a biosensor and analytic methods for more accurately measuring an analyte of interest in a biological sample.

Abstract translation: 在生物传感器中调节生物样品中生物分子探针或检测剂与目的分析物之间的结合相互作用的方法，该生物传感器具有多个测试位点阵列。 特别地，该方法调节这种生物传感器中电极附近的pH或离子浓度梯度。 调节结合相互作用的方法提供了生物传感器和分析方法，用于更精确地测量生物样品中感兴趣的分析物。