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    BIOMARKERS OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK, PROGNOSTIC MARKERS OF RECURRENCE IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK, AND METHODS THEREOF
    1.
    发明申请
    BIOMARKERS OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK, PROGNOSTIC MARKERS OF RECURRENCE IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK, AND METHODS THEREOF 审中-公开
    头颈鳞状细胞癌生物标志物，头颈鳞状细胞癌复发的预后标志物及其治疗方法

    公开(公告)号：WO2017077499A1

    公开(公告)日：2017-05-11

    申请号：PCT/IB2016/056652

    申请日：2016-11-04

    Applicant: GENOMICS APPLICATIONS AND INFORMATICS TECHNOLOGY (GANIT) LABS

    Inventor： PANDA, Binay ,  KRISHNAN, Neeraja M ,  GUPTA, Saurabh

    IPC: G01N33/574 ,  C12Q1/00

    CPC classification number: C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158

    Abstract: The present disclosure relates to biomarkers of cancer and prognostic markers of recurrence in cancer, particularly head and neck squamous cell carcinomas (HNSCC), method of analysing role of said biomarkers/prognostic markers, corresponding methods of detecting cancer and determining/predicting recurrence, and kits thereof. In particular, the present disclosure relates to analyzing aberrations and providing biomarkers of HNSCC and prognostic markers of recurrence in HNSCC and associated methods/applications. Further, said prognostic markers differentiate non-recurring, loco-regionally recurring and distant metastatic tumors.

    Abstract translation: 本发明涉及癌症生物标志物和癌症复发预后标志物，尤其是头颈部鳞状细胞癌（HNSCC），分析所述生物标志物/预后标志物作用的方法，检测相应的检测方法 癌症和确定/预测复发以及它们的试剂盒。 具体而言，本公开涉及分析畸变并提供HNSCC的生物标志物和HNSCC及相关方法/应用中的复发的预后标志物。 此外，所述预后标记区分非复发性，局部区域复发和远处转移的肿瘤。

    GENE SIGNATURE IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF
    2.
    发明申请
    GENE SIGNATURE IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF 审中-公开
    头和鼻（HNSCC）鳞状细胞癌基因标签及其应用

    公开(公告)号：WO2016199109A1

    公开(公告)日：2016-12-15

    申请号：PCT/IB2016/053479

    申请日：2016-06-13

    Applicant: GENOMICS APPLICATIONS AND INFORMATICS TECHNOLOGY (GANIT) LABS

    Inventor： PANDA, Binay

    IPC: C12Q1/68 ,  G01N33/574

    CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/158

    Abstract: The present disclosure relates to indicators/biomarkers of head and neck squamous cell carcinomas (HNSCC), method of analysing role of said indicators/biomarkers in HNSCC, method of detecting HNSCC with the help of these indicators/biomarkers and method of detecting the indicators/biomarkers in a sample. In particular, the present disclosure relates to 8-gene signature in head and neck squamous cell carcinomas (HNSCC), specifically in squamous cell carcinoma of larynx and hypopharynx which serve as indicators/biomarkers for such carcinomas and associated methods.

    Abstract translation: 本公开涉及头颈鳞状细胞癌（HNSCC）的指标/生物标志物，HNSCC中所述指标/生物标志物的作用分析方法，借助这些指标/生物标志物检测HNSCC的方法和检测指标/ 样品中的生物标志物。 特别地，本公开涉及头颈部鳞状细胞癌（HNSCC）中的8-基因特征，特别是用作这些癌症和相关方法的指标/生物标志物的喉和咽下鳞状细胞癌。

    GENE ABERRATION(S) IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF
    4.
    发明申请
    GENE ABERRATION(S) IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF 审中-公开
    头和鼻（HNSCC）细胞细胞基因的遗传及其应用

    公开(公告)号：WO2016199107A1

    公开(公告)日：2016-12-15

    申请号：PCT/IB2016/053473

    申请日：2016-06-13

    Applicant: GENOMICS APPLICATIONS AND INFORMATICS TECHNOLOGY (GANIT) LABS

    Inventor： PANDA, Binay

    IPC: C12Q1/68 ,  G01N33/574

    CPC classification number: C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57407

    Abstract: The present disclosure relates to aberration in gene(s) as indicators/biomarkers of head and neck squamous cell carcinomas (HNSCC), method of analysing the role of said indicators/biomarkers in HNSCC, corresponding methods of detection of HNSCC, kits for detection of HNSCC, use of gene aberration for detection of HNSCC. In particular, the present disclosure relates to analyzing gene expression changes and gene fusion events in head and neck squamous cell carcinomas (HNSCC), specifically in squamous cell carcinoma of larynx and/or hypopharynx which serve as indicators/biomarkers for such carcinomas and associated methods/applications.

    Abstract translation: 本公开内容涉及作为头颈鳞状细胞癌（HNSCC）的指标/生物标志物的基因的畸变，分析HNSCC中所述指示物/生物标志物的作用的方法，相应的HNSCC检测方法，用于检测 HNSCC，使用基因像差检测HNSCC。 特别地，本公开涉及分析头颈鳞状细胞癌（HNSCC）中的基因表达变化和基因融合事件，特别是用作这些癌症和相关方法的指示剂/生物标志物的喉和/或下咽鳞状细胞癌 /应用。

    MIRNA ABERRATION(S) IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF
    5.
    发明申请
    MIRNA ABERRATION(S) IN SQUAMOUS CELL CARCINOMA OF HEAD AND NECK (HNSCC) AND APPLICATIONS THEREOF 审中-公开
    头和鼻（HNSCC）鳞状细胞癌中的MIRNA ABERRATION及其应用

    公开(公告)号：WO2016199094A1

    公开(公告)日：2016-12-15

    申请号：PCT/IB2016/053444

    申请日：2016-06-10

    Applicant: GENOMICS APPLICATIONS AND INFORMATICS TECHNOLOGY (GANIT) LABS

    Inventor： PANDA, Binay

    IPC: C12Q1/68 ,  G01N33/574

    CPC classification number: C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/574

    Abstract: The present disclosure relates to aberrations in microRNAs as indicators/biomarkers of head and neck squamous cell carcinomas (HNSCC), method of analysing the role of said indicators/biomarkers in HNSCC, corresponding methods of detection of HNSCC, use and kits thereof. In particular, the present disclosure relates to aberrations in microRNAs in head and neck squamous cell carcinomas (HNSCC), specifically in squamous cell carcinoma of larynx and/or hypopharynx which serve as indicators/biomarkers for such carcinomas and associated methods.

    Abstract translation: 本公开涉及作为头颈鳞状细胞癌（HNSCC）的指标/生物标志物的微小RNA中的像差，HNSCC中所述指示剂/生物标志物的作用的分析方法，相应的HNSCC检测方法及其用途和试剂盒。 特别地，本公开涉及头颈部鳞状细胞癌（HNSCC）中的微小RNA中的畸变，特别是用作这些癌症和相关方法的指示剂/生物标志物的喉和/或下咽鳞状细胞癌。

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