公开(公告)号：WO2006078241A1

公开(公告)日：2006-07-27

申请号：PCT/US2005/001571

申请日：2005-01-20

Applicant: SERENE MEDICAL, INC. ,  GONZALES, Gilbert, Rene ,  GONZALES, Nicholas, L.

Inventor： GONZALES, Gilbert, Rene ,  GONZALES, Nicholas, L.

IPC: A61K9/46

CPC classification number: A61K9/0004 ,  A61K9/2086 ,  A61K31/00

Abstract: Pharmaceutical compositions comprising one or more medicaments in a pharmaceutically acceptable effervescent formulation. The effervescent formulation includes a first gas-dispersing component and a second gas-generating effervescent component, wherein at least one first gas is released from the first gas-dispersing component and at least one second gas is generated and evolved from the second gas-generating effervescent component, upon contact with a minimal amount of water. The formulation is placed in an aqueous vehicle wherein the formulation effervesces gases causes penetration, dispersion and distribution of the medicaments in the vehicle. The vehicle, which may be any ordinary food or beverage chosen by the patient, is then ingested by the patient for delivery of a dosage of the medicaments.

Abstract translation: 在药学上可接受的泡腾制剂中包含一种或多种药物的药物组合物。 所述泡腾制剂包括第一气体分散组分和第二气体产生泡腾组分，其中至少一种第一气体从所述第一气体分散组分中释放并且产生至少一种第二气体并从所述第二气体产生 与最少量的水接触时的泡腾成分。 将配方置于水性载体中，其中制剂起泡气体引起药物在载体中的渗透，分散和分布。 然后由患者选择的可能是任何普通食物或饮料的车辆由患者摄取以递送药物的剂量。

公开(公告)号：WO1997016035A1

公开(公告)日：1997-05-01

申请号：PCT/US1996017126

申请日：1996-10-24

Applicant: GONZALES, Gilbert, Rene

IPC: H04Q01/00

CPC classification number: G09B21/003 ,  G08B6/00

Abstract: The present invention discloses a device and method for use in tactile communications adaptable for use by anyone able to recognize messages written in a language known to them. The present invention uses a series of sequentially firing vibromechanical stimulators (46) vibrating against the skin or other suitably tactile sensitive area of the wearer. The vibromechanical stimulators (46) are arranged in a substantially two dimensional array (34) over the skin and are then triggered individually and in sequence, following a set of patterns representative of the symbols in the language recognizable to the wearer to tactually convey the message. The wearer cognitively perceives the tactual stimulation as a line or lines drawn on the skin or suitably tactile sensitive area that resemble the symbols used to communicate between the message sender and the wearer.

Abstract translation: 本发明公开了一种用于触觉通信的设备和方法，适用于任何能够识别以他们所熟知的语言书写的消息的用户使用。 本发明使用一系列顺序地发射的振动机械刺激器（46），其对穿着者的皮肤或其它合适的触觉敏感区域进行振动。 机械刺激器（46）以皮肤上的基本上二维的阵列（34）布置，并且随后按照代表佩戴者可识别的语言中的符号的一组模式，依次触发，以触觉地传达消息 。 佩戴者认知地将触觉刺激视为在皮肤上绘制的线条或线条，或类似于用于在消息发送者和佩戴者之间通信的符号的适当的触觉敏感区域。

公开(公告)号：WO2005040434A2

公开(公告)日：2005-05-06

申请号：PCT/FR2004002700

申请日：2004-10-21

Applicant: FRAMATOME ANP ,  GILBERT RENE

Inventor： GILBERT RENE

IPC: G21C1/09 ,  G21C13/02 ,  G21D1/02 ,  C21C

CPC classification number: G21C13/022 ,  G21C1/09 ,  G21D1/02 ,  G21Y2002/202 ,  G21Y2002/304 ,  G21Y2004/30 ,  G21Y2004/40 ,  Y02E30/40

Abstract: The invention relates to a method which comprises filling the primary circuit (1) with water and setting the water pressure in said primary circuit (1) at a level allowing the operation of the primary pumps (15, 25, 35), operating the first primary pump (35) of a loop (33) which is not connected to the pressurizer (17) by a pressurization line (18), continuously exhausting the gas contained in the primary circuit (1) and carried by the water circulated by the pump (35) in the upper part of the vessel (12) at least during the primary pump operation, stopping the first primary pump (35) and successively operating the other primary pumps (25, 15) and, simultaneously, all the primary pumps (15, 25, 35) by simultaneously exhausting the gas in the upper part of said vessel (12) and carrying out the final venting of the primary circuit at the uppermost points of said primary circuit (1), by means of first and second exhaust lines (27, 22), respectively connected to the cover of the vessel (12) and to the pressurizer (17). Said invention also relates to a device comprising means for continuously exhausting gas reaching the upper part (12a) of the vessel (12) during the operation of the pumps.

Abstract translation: 本发明涉及一种方法，其包括用初级回路（1）填充水并将所述主回路（1）中的水压设定在允许操作第一泵（15,25,35）的主泵 通过加压管线（18）未连接到加压器（17）的回路（33）的主泵（35）连续排出包含在主回路（1）中的气体并由泵循环的水 （35），并且连续地操作其它主泵（25,15），并且同时地将所有的主泵（ 通过同时排出所述容器（12）的上部中的气体并且通过第一和第二排气在第一回路（1）的最上点处执行初级回路的最终排气， （27,22），分别连接到容器（12）的盖子上 ）和加压器（17）。 所述发明还涉及一种装置，其包括用于在泵的操作期间连续排出到达容器（12）的上部（12a）的气体的装置。