Abstract:
The invention concerns a method for obtaining and selecting monoclonal antibodies by an ADDC-type test, said antibodies capable of activating type III Fc gamma receptors and having a particular glycan structure. The inventive anti-D antibodies can be used for preventing Rhesus isoimmunisation in Rh negative persons, in particular for haemolytic disease in a new-born baby or for uses such as idiopathic thrombocytopenic purpura (ITP).
Abstract:
A process is provided for rapidly holding an optical article having a convex surface on a holder of a lens machining equipment, the holder being equipped with a suction chuck comprising a cavity with a side wall and sealing means on a front end of the side wall, comprising the following steps: /a/ providing a flexible curved wafer with a concave surface arranged to close the cavity at the front end of the side wall; /b/ a fixing step in which the wafer is fixed onto the holder by providing vacuum between the concave surface of the wafer and the suction chuck; and IcI a pressing step in which the concave surface of the optical article is pressed onto the concave surface of the wafer, an adhesive material being arranged between the wafer and the optical article The assembly is tight enough for sustaining machining forces, and the lens can be released rapidly.
Abstract translation:提供了一种用于在透镜加工设备的保持器上快速保持具有凸表面的光学制品的工艺,所述保持器装备有吸盘,所述吸盘包括侧壁的空腔和在所述侧壁的前端上的密封装置, 包括以下步骤:/ a /提供柔性弯曲晶片,其具有设置成在侧壁的前端处封闭空腔的凹面; / b /固定步骤,其中通过在晶片的凹面与吸盘之间提供真空将晶片固定在支架上; 和IcI是将光学物品的凹面按压在晶片的凹面上的按压工序,配置在晶片和光学制品之间的粘合剂材料该组件足够紧以维持加工力,透镜可以 快速释放
Abstract:
The invention concerns chimeric monoclonal antibodies, humanized or human produced in selected cell lines, said antibodies exhibiting high affinity for the CD16 receptor of effector cells of the immune system and hence capable of inducing high ADCC, but also the property of inducing cytokine and interleukin secretion, in particular IFN gamma , which can enhance the ADCC activity of effector cells and hence be used for treating cancers and infections by pathogenic agents.
Abstract:
A process for applying a film onto a lens surface and bearing a coating which is sensitive to the temperature; applying a pressure on the film to urge it against the lens (L) with a curable adhesive there between to conform the film to the lens maintaining pressure on the film, activating the adhesive and promoting adhesion between the film and the lens stopping activation and releasing applied pre.ssure; and recovering the lens with the film adhered thereon; wherein during pressure application step and activation step the second main surface of the lens substrate (L) is at least partly in contact with a matching surface of a non deformable heat sink block (21) and during activation step the first main surface of the lens substrate is heated at a temperature T, while the second main surface of the lens substrate is essentially heated by conduction through the lens substrate, whereby the temperature on the second main surface of the lens substrate is at least 10°C lower than temperature T without the use of any active cooling.
Abstract:
La présente invention concerne des anticorps monoclonaux chimériques, humanisés ou humains qui sont produits dans des lignées cellulaires sélectionnées, lesdits anticorps présentant une forte affinité pour le récepteur CD 16 des cellules effectrices du système immunitaire et ainsi capables d'induire une forte ADCC, mais également la propriété d'induire la sécrétion de cytokines et d'interleukines, en particulier l' IFNγ, qui peut renforcer l'activité ADCC des cellules effectrices et ainsi s'appliquer au traitement des cancers et des infections par des agents pathogènes.
Abstract:
Process for the specific synthesis of monoesters between a fatty acid and O-isopropyliden-1,2alpha-D-glucofurannose comprising the acylation of di-O-isopropydilen-1,2:5,6alpha-D-glucofurannose and the elimination on an ion exchange resin of ions (H+) from the protection isopropyliden-5,6 to obtain O-acyl-3 O-isopropyliden-1,2alpha-D-glucofurannose. The latter may be quantitatively transformed into pure O-acyl-6 O-isopropyliden-1,2alpha-D-glucofurannose. These monoesters wherein acyl means (i), with R=alkyl having a number of carbons equal to or higher than 7, are fermentation adjuvants, swelling agents, gelifying agents, emulsifiers, microemulsifiers usable in the food industry, pharmacy, sanitary industry and cosmetics.
Abstract:
Systems for transferring at least one coating from a carrier to a surface of an optical article which comprise: an optical article to be coated; a flexible carrier bearing at least one coating to be transferred; an inflatable membrane; and a deformable part that is able to match the geometry of a surface of the optical article when a pressure is exerted on the optical article through inflation of the inflatable membrane. Also describes are methods and processes of using such systems; carriers for use in such systems, methods, and processes; and optical articles made using such systems, methods, and processes.
Abstract:
La présente invention concerne l'utilisation de cations métalliques, notamment du Zinc, pour cristalliser le fragment Fc d’un anticorps anti Rhésus D. Mutagnèse dirigée des histidines situées aux residus 310 et 435.
Abstract:
The invention concerns chimeric monoclonal antibodies, humanized or human produced in selected cell lines, said antibodies exhibiting high affinity for the CD16 receptor of effector cells of the immune system and hence capable of inducing high ADCC, but also the property of inducing cytokine and interleukin secretion, in particular IFN gamma , which can enhance the ADCC activity of effector cells and hence be used for treating cancers and infections by pathogenic agents.
Abstract:
The invention relates to a method of dip-coating a lens comprising the steps of: - immersing the lens (10) in a coating solution bath (2) having a horizontal coating solution surface (4), and - withdrawing the lens (10) from said bath (2) through said solution surface (4), wherein the step of withdrawing is performed with a movement of the lens such that the orientation of the lens (10) varies continuously, from a position in which the optical axis (A) of the lens (10) is inclined upwards and towards the concave surface (12) of said lens (10) when said lens (10) starts emerging from said bath (2) to a position in which the optical axis (A) of the lens (10) is inclined upwards and towards the convex surface (11) of said lens (10) when said lens (10) finishes emerging from said bath (2).