公开(公告)号：WO2006038080A8

公开(公告)日：2006-07-27

申请号：PCT/IB2005002912

申请日：2005-09-30

Applicant: CLEARLAB INTERNAT PTE LTD ,  NEWMAN STEPHEN D ,  GLASBEY TREVOR O

Inventor： NEWMAN STEPHEN D ,  GLASBEY TREVOR O

IPC: A61L12/08 ,  A61K9/00 ,  A61L12/14 ,  C11D3/00

CPC classification number: C11D3/0078 ,  A61L12/04 ,  C11D17/003

Abstract: An aqueous contact lens storage solution comprises a viscoelastic rheology modifier; and not more than 0.3% w/v of an alkali metal salt; the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg, and the solution has viscoelastic properties, even if heat sterilized at 121°C for at least 15 minutes. The viscoelastic rheology modifier may be selected from the following acids or their alkali metal salts: hyaluronic acid, poly(acrylic acid), crosslinked poly(acrylic acid), poly(methacrylic acid), carboxymethyl cellulose, alginic acid and mixtures thereof. The alkali metal salt may be present in an amount of from 0.01% to 0.3% w/v, and be selected from sodium chloride, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium tetraborate, sodium citrate, sodium acetate, sodium lactate, potassium chloride, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, potassium tetraborate, potassium citrate, potassium acetate, potassium lactate and mixtures thereof. The solution may be an inhomogeneous combination of a gel component and an additional liquid component. If so, the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg when in a homogeneous form.

Abstract translation: 水溶性隐形眼镜储存溶液包含粘弹性流变改性剂; 和不超过0.3％w / v的碱金属盐; 该溶液具有6.0至8.0的渗透压和100至400mOsm / kg的重量摩尔渗透压浓度，并且该溶液具有粘弹性，即使在121℃下加热灭菌至少15分钟。 粘弹性流变改性剂可以选自以下酸或其碱金属盐：透明质酸，聚（丙烯酸），交联聚（丙烯酸），聚（甲基丙烯酸），羧甲基纤维素，海藻酸及其混合物。 碱金属盐的存在量可以为0.01〜0.3％w / v，选自氯化钠，碳酸氢钠，磷酸二氢钠，磷酸氢二钠，磷酸三钠，四硼酸钠，柠檬酸钠，乙酸钠 ，乳酸钠，氯化钾，碳酸氢钾，磷酸二氢钾，磷酸氢二钾，磷酸三钾，四硼酸钾，柠檬酸钾，乙酸钾，乳酸钾及其混合物。 溶液可以是凝胶组分和另外的液体组分的不均匀组合。 如果是这样，当均匀形式时，溶液的pH值在6.0和8.0之间，重量摩尔渗透压浓度在100和400mOsm / kg之间。

公开(公告)号：WO2006038080A3

公开(公告)日：2006-09-21

申请号：PCT/IB2005002912

申请日：2005-09-30

Applicant: CLEARLAB INTERNAT PTE LTD ,  NEWMAN STEPHEN D ,  GLASBEY TREVOR O

Inventor： NEWMAN STEPHEN D ,  GLASBEY TREVOR O

IPC: A61L12/08 ,  A45C11/00 ,  A61K9/00 ,  A61L12/14 ,  C11D3/00

CPC classification number: C11D3/0078 ,  A61L12/04 ,  C11D17/003

Abstract: An aqueous contact lens storage solution comprises a viscoelastic rheology modifier; and not more than 0.3% w/v of an alkali metal salt; the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg, and the solution has viscoelastic properties, even if heat sterilized at 121°C for at least 15 minutes. The viscoelastic rheology modifier may be selected from the following acids or their alkali metal salts: hyaluronic acid, poly(acrylic acid), crosslinked poly(acrylic acid), poly(methacrylic acid), carboxymethyl cellulose, alginic acid and mixtures thereof. The alkali metal salt may be present in an amount of from 0.01% to 0.3% w/v, and be selected from sodium chloride, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium tetraborate, sodium citrate, sodium acetate, sodium lactate, potassium chloride, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, potassium tetraborate, potassium citrate, potassium acetate, potassium lactate and mixtures thereof. The solution may be an inhomogeneous combination of a gel component and an additional liquid component. If so, the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg when in a homogeneous form.

Abstract translation: 含水隐形眼镜储存溶液包含粘弹性流变改性剂; 和不多于0.3％w / v的碱金属盐; 该溶液具有6.0至8.0的pH值和100至400mOsm / kg的渗透度，并且该溶液具有粘弹性，即使在121℃下加热灭菌至少15分钟。 粘弹性流变改性剂可以选自下列酸或其碱金属盐：透明质酸，聚（丙烯酸），交联聚（丙烯酸），聚（甲基丙烯酸），羧甲基纤维素，海藻酸及其混合物。 碱金属盐可以以0.01％至0.3％w / v的量存在，并且选自氯化钠，碳酸氢钠，磷酸二氢钠，磷酸氢二钠，磷酸三钠，四硼酸钠，柠檬酸钠，乙酸钠 ，乳酸钠，氯化钾，碳酸氢钾，磷酸二氢钾，磷酸氢二钾，磷酸三钾，四硼酸钾，柠檬酸钾，乙酸钾，乳酸钾及其混合物。 该溶液可以是凝胶组分和另外的液体组分的不均匀组合。 如果是这样的话，当处于均匀形式时，该溶液具有6.0至8.0之间的pH和100至400mOsm / kg之间的渗透压。

公开(公告)号：WO2006038080A2

公开(公告)日：2006-04-13

申请号：PCT/IB2005/002912

申请日：2005-09-30

Applicant: CLEARLAB PTE LTD ,  NEWMAN, Stephen, D. ,  GLASBEY, Trevor, O.

Inventor： NEWMAN, Stephen, D. ,  GLASBEY, Trevor, O.

IPC: A61L12/08 ,  A61L12/14 ,  C11D3/00 ,  A61K9/00

CPC classification number: C11D3/0078 ,  A61L12/04 ,  C11D17/003

Abstract: An aqueous contact lens storage solution comprises a viscoelastic rheology modifier; and not more than 0.3% w/v of an alkali metal salt; the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg, and the solution has viscoelastic properties, even if heat sterilized at 121°C for at least 15 minutes. The viscoelastic rheology modifier may be selected from the following acids or their alkali metal salts: hyaluronic acid, poly(acrylic acid), crosslinked poly(acrylic acid), poly(methacrylic acid), carboxymethyl cellulose, alginic acid and mixtures thereof. The alkali metal salt may be present in an amount of from 0.01% to 0.3% w/v, and be selected from sodium chloride, sodium bicarbonate, sodium dihydrogen phosphate, disodium hydrogen phosphate, trisodium phosphate, sodium tetraborate, sodium citrate, sodium acetate, sodium lactate, potassium chloride, potassium bicarbonate, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, tripotassium phosphate, potassium tetraborate, potassium citrate, potassium acetate, potassium lactate and mixtures thereof. The solution may be an inhomogeneous combination of a gel component and an additional liquid component. If so, the solution has a pH of between 6.0 and 8.0 and an osmolality of between 100 and 400 mOsm/kg when in a homogeneous form.

Abstract translation: 隐形眼镜储存溶液包含粘弹性流变改性剂; 和不多于0.3％w / v的碱金属盐; 即使在121℃加热灭菌至少15分钟，该溶液的pH值在6.0-8.0之间，渗透度在100-400mOsm / kg之间，溶液具有粘弹性。 粘弹性流变改性剂可以选自下列酸或其碱金属盐：透明质酸，聚（丙烯酸），交联聚（丙烯酸），聚（甲基丙烯酸），羧甲基纤维素，海藻酸及其混合物。 碱金属盐可以以0.01％至0.3％w / v的量存在，并且选自氯化钠，碳酸氢钠，磷酸二氢钠，磷酸氢二钠，磷酸三钠，四硼酸钠，柠檬酸钠，乙酸钠 ，乳酸钠，氯化钾，碳酸氢钾，磷酸二氢钾，磷酸氢二钾，磷酸三钾，四硼酸钾，柠檬酸钾，乙酸钾，乳酸钾及其混合物。 该溶液可以是凝胶组分和另外的液体组分的不均匀组合。 如果是这样，当处于均匀形式时，该溶液具有6.0至8.0之间的pH和100至400mOsm / kg之间的渗透压。

公开(公告)号：WO2005031400A3

公开(公告)日：2005-08-18

申请号：PCT/US2004031651

申请日：2004-09-27

Applicant: 1 800 CONTACTS INC ,  NEWMAN JAMES J ,  NEWMAN STEVEN D ,  TIPTON WADE M ,  GLASBEY TREVOR O ,  SUTTON HOWARD S

Inventor： NEWMAN JAMES J ,  NEWMAN STEVEN D ,  TIPTON WADE M ,  GLASBEY TREVOR O ,  SUTTON HOWARD S

IPC: B29D11/00 ,  G02B20060101 ,  G02C7/04

CPC classification number: C08F220/06 ,  C08F220/26 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

Abstract: The present invention provides a process of preparing a contact lens comprising polymerising a polymerisable mixture, wherein said polymerisable mixture has the principal polymerisable monomers hydroxypropyl methacrylate (HPMA) and 2,3-dihydroxypropyl methacrylate (GMA). In another embodiment, the present invention provides an unhydrated contact lens comprising a polymer containing an alkali metal salt of (meth)acrylic acid and a process of preparing an unhydrated contact lens comprising polymerising a polymerisable mixture, wherein said polymerisable mixture includes an alkali metal salt of (meth)acrylic acid.

Abstract translation: 本发明提供一种制备隐形眼镜的方法，其包括聚合可聚合混合物，其中所述可聚合混合物具有主要的可聚合单体羟丙基甲基丙烯酸酯（HPMA）和甲基丙烯酸2,3-二羟丙基酯（GMA）。 在另一个实施方案中，本发明提供了一种包含含有（甲基）丙烯酸的碱金属盐的聚合物的非水合隐形眼镜，以及制备包含使可聚合混合物聚合的未水合隐形眼镜的方法，其中所述可聚合混合物包括碱金属盐 的（甲基）丙烯酸。

公开(公告)号：WO2005031400A2

公开(公告)日：2005-04-07

申请号：PCT/US2004/031651

申请日：2004-09-27

Applicant: 1-800 CONTACTS, INC. ,  NEWMAN, James, J. ,  NEWMAN, Steven, D. ,  TIPTON, Wade, M. ,  GLASBEY, Trevor, O. ,  SUTTON, Howard, S.

Inventor： NEWMAN, James, J. ,  NEWMAN, Steven, D. ,  TIPTON, Wade, M. ,  GLASBEY, Trevor, O. ,  SUTTON, Howard, S.

IPC: G02B

CPC classification number: C08F220/06 ,  C08F220/26 ,  C08F220/32 ,  G02B1/043 ,  C08L33/14

Abstract: The present invention provides a process of preparing a contact lens comprising polymerising a polymerisable mixture, wherein said polymerisable mixture has the principal polymerisable monomers hydroxypropyl methacrylate (HPMA) and 2,3-dihydroxypropyl methacrylate (GMA). In another embodiment, the present invention provides an unhydrated contact lens comprising a polymer containing an alkali metal salt of (meth)acrylic acid and a process of preparing an unhydrated contact lens comprising polymerising a polymerisable mixture, wherein said polymerisable mixture includes an alkali metal salt of (meth)acrylic acid.

Abstract translation: 本发明提供了制备隐形眼镜的方法，所述隐形眼镜包含聚合可聚合混合物，其中所述可聚合混合物具有主要可聚合单体甲基丙烯酸羟丙酯（HPMA）和甲基丙烯酸2,3-二羟丙酯（GMA）。 在另一个实施方案中，本发明提供包含含有（甲基）丙烯酸的碱金属盐的聚合物的未水合隐形眼镜和制备包含聚合可聚合混合物的未水合隐形眼镜的方法，其中所述可聚合混合物包含碱金属盐 的（甲基）丙烯酸。