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公开(公告)号：WO2006027567A3
公开(公告)日：2006-03-16
申请号：PCT/GB2005/003431
申请日：2005-09-06
申请人： BIOCOMPATIBLES UK LIMITED , LEWIS, Andrew, Lennard , STRATFORD, Peter, William , GONZALEZ-FAJARDO, Maria Victoria , TANG, Yiqing
发明人： LEWIS, Andrew, Lennard , STRATFORD, Peter, William , GONZALEZ-FAJARDO, Maria Victoria , TANG, Yiqing
IPC分类号： A61K9/16
摘要： An embolic composition comprises microspheres formed of water-insoluble water-swellable anionic polymer having swollen diameter more than 100µm, and a cationic camptothecin compound, preferably irinotecan. The microspheres are preferably formed of crosslinked polyvinylalcohol, preferably of ethylenically unsaturated polyvinylalcohol macromer, crosslinked with anionic ethylenically unsaturated anionic comonomer. The compositions are used to treat hypervascular tumours for instance colorectal metastases of the liver.
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2.发明申请
公开(公告)号：WO2007090897A1
公开(公告)日：2007-08-16
申请号：PCT/EP2007/051299
申请日：2007-02-09
申请人： BIOCOMPATIBLES UK LIMITED , LEWIS, Andrew Lennard , TANG, Yiqing , GONZALEZ FAJARDO, Maria Victoria
IPC分类号： A61K9/16 , A61K9/50 , A61K31/57 , A61K31/436 , A61K31/337 , A61P35/00
CPC分类号： A61K9/1635 , A61K9/0019 , A61K9/1682 , A61K31/337 , A61K31/436 , A61K31/57
摘要： A process is described for loading hydrophilic polymer particles with a water- insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.
摘要翻译： 描述了用水不溶性溶剂可溶性药物负载亲水聚合物颗粒的方法。 颗粒优选是栓剂。 该方法提供在表面和表面层中具有很少或不具有药物的颗粒，由此突发效应最小化。 药物沉淀在颗粒的核心，导致释放。 该药物是例如紫杉醇，雷帕霉素，地塞米松或布洛芬。
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公开(公告)号：WO2009022190A1
公开(公告)日：2009-02-19
申请号：PCT/GB2008/050722
申请日：2008-08-18
申请人： BIOCOMPATIBLES UK LIMITED , LEWIS, Andrew Lennard , FORSTER, Richard, Edward, John , GONZALEZ-FAJARDO, Maria Victoria , TANG, Yiqing , LLOYD, Andrew William , PHILLIPS, Gary, James
发明人： LEWIS, Andrew Lennard , FORSTER, Richard, Edward, John , GONZALEZ-FAJARDO, Maria Victoria , TANG, Yiqing , LLOYD, Andrew William , PHILLIPS, Gary, James
CPC分类号： A61K9/1635
摘要： A composition comprising microspheres of a polymer matrix, having two different pharmaceutical actives having complementary, usually synergistic, activity in killing cells. The compositions have particular utility for treating tumours. Useful combinations are doxorubicin with rapamycin, irinotecan with ibuprofen, ibuprofen with doxorubicin and irinotecan with doxorubicin. The polymer matrix is preferably a crosslinked polyvinyl alcohol. The drugs may be included in the same microsphere, or microspheres each with an individual pharmaceutical agent may be mixed together. The microspheres are preferably used in chemoembolisation of tumours.
摘要翻译： 包含聚合物基质微球的组合物，具有两种不同的药物活性物质，其在杀伤细胞中具有互补的，通常协同的活性。 该组合物具有治疗肿瘤的特殊用途。 有用的组合是多柔比星与雷帕霉素，伊立替康与布洛芬，布洛芬与多柔比星和伊立替康与多柔比星。 聚合物基质优选为交联聚乙烯醇。 药物可以包含在相同的微球中，或者每个具有单个药剂的微球可以混合在一起。 微球优选用于肿瘤的化学栓塞。
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公开(公告)号：WO2006013376A3
公开(公告)日：2006-02-09
申请号：PCT/GB2005/003065
申请日：2005-08-04
申请人： BIOCOMPATIBLES UK LIMITED , LEWIS, Andrew, Lennard , STRATFORD, Peter, William , GONZALEZ FAJARDO, Maria, Victoria , GOREISH, Hind, Hassan, Sid, Ahmed
发明人： LEWIS, Andrew, Lennard , STRATFORD, Peter, William , GONZALEZ FAJARDO, Maria, Victoria , GOREISH, Hind, Hassan, Sid, Ahmed
摘要： A pharmaceutical composition for malignant tumour embolisation comprises a polymer and, associated with the polymer in a releasable form, a COX inhibitor, e.g. a non-steroidal anti inflammatory drug, such as ibuprofen. The polymer is preferably-in particulate form, such as in the form of microspheres. A suitable polymer is a crosslinked polyvinyl alcohol polymer formed by the copolymerisation of PVA macromer with other ethylenically unsaturated monomers. The composition provides a synergistic treatment for the symptoms of malignant tumours, leading to tumour necrosis or ischaemia, with anti-angiogenic effects, promotion of apoptosis, decrease in invasiveness of tumour cells and resultant tumour regression.
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公开(公告)号：WO2004071495A1
公开(公告)日：2004-08-26
申请号：PCT/GB2004/000548
申请日：2004-02-12
申请人： BIOCOMPATIBLES UK LIMITED , LEWIS, Andrew, Lennard , STRAFORD, Peter, William , LEPPARD, Simon, William , HALL, Brenda , GONZALEZ FAJARDO, Maria, Victoria , GARCIA, Pedro
发明人： LEWIS, Andrew, Lennard , STRAFORD, Peter, William , LEPPARD, Simon, William , HALL, Brenda , GONZALEZ FAJARDO, Maria, Victoria , GARCIA, Pedro
IPC分类号： A61K9/16
CPC分类号： A61K9/1635
摘要： A composition for chemoembolotherapy of solid tumours comprises particles of a water-insoluble water-swellable synthetic anionic polymer and, absorbed therein an anthracycline. Suitably the polymer is a poly(vinyl alcohol) based polymer and the drug is doxorubicin.
摘要翻译： 用于实体肿瘤化学疗法的组合物包括水不溶性水溶胀性合成阴离子聚合物颗粒，并在其中吸收蒽环类。 适合地，聚合物是基于聚（乙烯醇）的聚合物，并且药物是多柔比星。
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