公开(公告)号：WO2022175948A1

公开(公告)日：2022-08-25

申请号：PCT/IL2022/050187

申请日：2022-02-16

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： KAKHLON, Or ,  WEIL, Miguel, Enrique

IPC: A61K31/381 ,  A61K31/44 ,  A61K31/4412 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10

Abstract: Disclosed herein is a polypeptide including a pharmaceutical composition for use in prevention or treatment of a disease or a disorder associated with lysosomal storage and an autophagy-misregulation associated disease. Further provided are agents that bind a region of an N-terminal domain of a lysosomal-associated membrane protein 1 (LAMP-1), and methods for treating or preventing development of a disease or a disorder associated with lysosomal storage, polyglucosan accumulation or abnormal glycogen accumulation and autophagy-misregulation in a subject in need thereof.

公开(公告)号：WO2022101911A1

公开(公告)日：2022-05-19

申请号：PCT/IL2021/051345

申请日：2021-11-11

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. ,  AZRIELI COLLEGE OF ENGINEERING JERUSALEM

Inventor： ABU AMMAR, Aiman ,  HAYTAM, Kasem

IPC: A61K9/70 ,  A61K9/00 ,  A61K31/4174 ,  A61P31/10 ,  A61K47/34

Abstract: A film and a method for use thereof such as for the administration of a biologically active agent or for therapy are provided. Specifically, a film, composed of a biodegradable material having a mucoadhesive surface comprising a plurality of mushroom-type structures is provided.

公开(公告)号：WO2021191895A1

公开(公告)日：2021-09-30

申请号：PCT/IL2021/050318

申请日：2021-03-22

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： PELED, Amnon ,  LEVI, Shira

IPC: A61K31/4015 ,  A61K31/44 ,  A61P31/00 ,  A61P35/00 ,  C12N5/07

Abstract: The present invention is directed to a method for treating an IFN-γ associated disease or disorder in a subject in need thereof, including administering to the subject a pharmaceutical composition including a therapeutically effective amount of a compound capable of manipulating or modulating PD -L1 signaling or pathway.

公开(公告)号：WO2020261266A1

公开(公告)日：2020-12-30

申请号：PCT/IL2020/050698

申请日：2020-06-23

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： LOTEM, Michal ,  HAJAJ, Emma ,  EISENBERG, Galit

IPC: A61K38/17 ,  A61K39/395 ,  A61P35/00

Abstract: The invention relates to cancer management, specifically to therapeutic combinations and methods for immunotherapy of tumors and malignancies. More specifically, embodiments of the invention provide compositions, methods, pharmaceutical packages and combined preparations employing the use of a SLAMF6-mediated T cell activator in combination with a LAG3 inhibitor.

公开(公告)号：WO2020234888A1

公开(公告)日：2020-11-26

申请号：PCT/IL2020/050566

申请日：2020-05-22

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： REUBINOFF, Benjamin Eithan ,  GROPP, Michal

IPC: C12N5/0735 ,  C12N5/074 ,  C12N5/0797

Abstract: A culture of human pluripotent stem cells (hPSCs) is disclosed. In the culture, more than 50 % of the hPSCs are formative hPSCs and are capable of renewing. Uses thereof are also disclosed.

公开(公告)号：WO2020031182A1

公开(公告)日：2020-02-13

申请号：PCT/IL2019/050891

申请日：2019-08-05

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： CHOWERS, Itay ,  BATASH, Tomer

IPC: A61M5/19 ,  A61M5/178 ,  A61M5/20

Abstract: There is provided herein a multi-lumen syringe for intraocular injection, including a first lumen, a second lumen, one or more needles fluidly connected to the lumens, and a needle sheath disposed about the one or more needles; wherein the needle sheath includes a plurality of n proximity/contact/pressure actuators on a distal rim of the needle sheath; wherein the syringe is switchable between at least two configurations: a first configuration in which at least one of the actuators is not actuated and each tip of the one or more needles is proximally positioned, and secured, relative to the distal rim; and a second configuration in which the n actuators are actuated, and the one or more needles are allowed to distally extend beyond the distal rim.

公开(公告)号：WO2019244157A1

公开(公告)日：2019-12-26

申请号：PCT/IL2019/050693

申请日：2019-06-20

Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： PAZ, Shai P. ,  KOLODNY, Yuval ,  BAR-SELA, Daniel ,  NAHMIAS, Yaakov ,  BUXBOIM, Amnon ,  BLINDER, Yaron ,  MINTZ, Yoav ,  FRIED, Elchanan

IPC: A61M25/00 ,  A61M25/01 ,  A61F2/04 ,  A61M39/24 ,  A61M25/10

Abstract: Disclosed is an endo-urethral catheter (100) for a male subject. The catheter includes a tube (102) and two balloons (106, 108). The tube includes a lumen (118) extending there along, an opening(s) (126) on a tube distal section (124), and a valve (136) positioned in the lumen. A first balloon is disposed about the tube distal section proximally to the opening(s). A second balloon is positioned proximally to the first balloon and distally to the valve. The catheter is configured to be deployed in the urinary system such that the first balloon is positioned in the bladder neck, and the second balloon is positioned adjacently and proximally to the urinary sphincter, thereby anchoring the catheter. The valve is configured to be controllably opened and shut, such as to respectively fluidly couple and decouple the bladder to the proximal end of the tube.

公开(公告)号：WO2019220441A1

公开(公告)日：2019-11-21

申请号：PCT/IL2019/050552

申请日：2019-05-15

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： BEN YEHUDA, Dina ,  ABD-ELRAHMAN, Ihab ,  PERLMAN, Riki ,  NACHMIAS, Boaz ,  BENITA, Simon ,  NASSAR, Taher

IPC: A61K38/17 ,  C07K14/47 ,  C12N15/11

Abstract: Compositions and methods for treating cancer resistant to an anti-cancer agent are provided. Accordingly, there is provided a method of treating cancer exhibiting a resistance to an anti-cancer agent in a subject comprising administering to the subject a therapeutically effective amount of t Livin. Also provided are compositions comprising t Livin attached to or encapsulated in a nanoparticle comprising poly(lactide-co-glycolide) and compositions comprising t Livin and a targeting moiety, wherein the t Livin is attached to or encapsulated in a cell penetrating agent and/or a stabilizing agent.

公开(公告)号：WO2019213584A1

公开(公告)日：2019-11-07

申请号：PCT/US2019/030680

申请日：2019-05-03

Applicant: EMORY UNIVERSITY ,  HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： SCHINAZI, Raymond, F. ,  COX, Bryan ,  CHAI, Chofit ,  GILADI, Hilla ,  GALUN, Eithan ,  AMBLARD, Franck

IPC: A61K31/5513

Abstract: Compounds, compositions and methods for modulating retinoic acid receptor-like orphan receptors (ROR) and associated diseases. Methods for treatment or prophylaxis of metabolic disorders, liver disorders or diseases, including NASH, immune disorders, central nervous system disorders, or cancer are disclosed.

公开(公告)号：WO2019008579A1

公开(公告)日：2019-01-10

申请号：PCT/IL2018/050721

申请日：2018-07-03

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： GOMORI, John, Moshe

IPC: A61N7/00

Abstract: Device for shave-free trans-cranial focused ultrasound (FUS) treatment and method for using same, the device including a scalp cover having a first inlet configured to allow supply of a gas into the scalp cover, and an outlet configured to allow outflow of ambient air contained within the scalp cover when the gas is being supplied, such that the ambient air contained within the scalp cover is replaced by the supplied gas.