公开(公告)号：WO2007053684A3

公开(公告)日：2007-10-04

申请号：PCT/US2006042652

申请日：2006-11-01

Applicant: UNIV KANSAS ,  MICHAELIS MARY LOUISE ,  GEORG INGRID GUNDA ,  HIMES RICHARD H ,  AUDUS KENNETH L

Inventor： MICHAELIS MARY LOUISE ,  GEORG INGRID GUNDA ,  HIMES RICHARD H ,  AUDUS KENNETH L

IPC: A61K31/42 ,  C07D498/00

CPC classification number: C07D498/04

Abstract: Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)- (3,5-bis(4-fluoro?henyl)tetrahydro-lH'-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-237A) and (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-lH-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH- 242A) exhibit neuroprotective effects via a mechanism that does not involve microtubule stabilization.

Abstract translation: 提供了GS-164的新型立体异构体。 （3R，5S，7α） - （3,5-双（4-氟苯基）四氢-1H'-恶唑并[3,4-c]恶唑-7a-基）甲醇（TH-237A ）和（3R，5S，7α） - （3,5-双（4-氟苯基）四氢-1H-恶唑并[3,4-c]恶唑-7a-基）甲醇（TH-242A） 机制，不涉及微管稳定。

公开(公告)号：WO2007053684A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/042652

申请日：2006-11-01

Applicant: UNIVERSITY OF KANSAS ,  MICHAELIS, Mary Louise ,  GEORG, Ingrid Gunda ,  HIMES, Richard H. ,  AUDUS, Kenneth L.

Inventor： MICHAELIS, Mary Louise ,  GEORG, Ingrid Gunda ,  HIMES, Richard H. ,  AUDUS, Kenneth L.

IPC: C07D491/02 ,  A61K31/424

CPC classification number: C07D498/04

Abstract: Novel stereoisomers of GS-164 are provided. The compounds, such as (3R,5S,7as)- (3,5-bis(4-fluoroρhenyl)tetrahydro-lH'-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH-237A) and (3R,5S,7as)-(3,5-bis(4-fluorophenyl)tetrahydro-lH-oxazolo[3,4-c]oxazol-7a-yl)methanol (TH- 242A) exhibit neuroprotective effects via a mechanism that does not involve microtubule stabilization.

Abstract translation: 提供GS-164的新型立体异构体。 化合物如（3R，5S，7as） - （3,5-双（4-氟苯基）四氢-1H'-恶唑并[3,4-c]恶唑-7a-基）甲醇（TH-237A ）和（3R，5S，7as） - （3,5-双（4-氟苯基）四氢-1H-恶唑并[3,4-c]恶唑-7a-基）甲醇（TH-242A）通过 不涉及微管稳定的机制。