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公开(公告)号：WO2022109023A1
公开(公告)日：2022-05-27
申请号：PCT/US2021/059721
申请日：2021-11-17
Applicant: IGM BIOSCIENCES, INC.
Inventor： CHEN, Daniel, S. , GODFREY, Wayne, R. , HERNANDEZ, Maria, Genevive, Hermoso , SISON, Iris , QAZI, Ibrahim , HART, Kevin, Charles , KOTTURI, Maya, Fay
Abstract: This disclosure provides methods of treating cancer comprising administering effector cell engaging molecules comprising one or more tumor targeting moieties and one or more effector cell engaging moieties. For example, the effector cell engaging molecules can have a greater cumulative potency for the tumor targeting moieties than the effector cell engaging moieties, the tumor targeting moieties can have greater avidity than the effector cell engaging moieties, and/or can be multimeric. The methods comprise, for example, administering different doses of effector cell engaging molecules based on the subject's symptoms and/or administering chimeric antigen receptor expressing cells.
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公开(公告)号：WO2022177870A1
公开(公告)日：2022-08-25
申请号：PCT/US2022/016379
申请日：2022-02-15
Inventor： KU, Zhiqiang , XIE, Xuping , HINTON, Paul , ZHANG, Ningyan , KEYT, Bruce , NG, Dean , CARROLL, Stephen , SHI, Pei-Young , AN, Zhiqiang
IPC: A61K39/215 , A61P31/14 , C07K14/165 , C07K16/10
Abstract: This disclosure provides multimeric binding molecules that bind to SARS-CoV-2. This disclosure also provides compositions comprising the multimeric binding molecules, polynucleotides that encode the multimeric binding molecules, and host cells that can produce the binding molecules. Further this disclosure provides methods of using the multimeric binding molecules, including methods for treating and preventing coronavirus disease 2019 (COVID-19).
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3.发明申请
公开(公告)号：WO2021231639A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032078
申请日：2021-05-12
Applicant: IGM BIOSCIENCES, INC.
Inventor： WANG, Beatrice , MATTHEW, Thomas J. , HUMKE, Eric William , SINCLAIR, Angus , CHEN, Daniel S. , KEYT, Bruce Alan , WANG, Ling
IPC: A61K41/00
Abstract: This disclosure provides therapeutic methods for treating cancer including combination therapy with a multimeric anti-DR5 antibody and a cancer therapy, e.g., radiation, an anthracycline, a folic acid analog, a platinum-based agent, a taxane, a topoisomerase II inhibitor, a SMAC mimetic, a vinca alkaloid, a Bruton's tyrosine kinase (BTK) inhibitor, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, a myeloid cell leukemia-1 (Mcl-1) inhibitor, or any combination thereof.
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公开(公告)号：WO2019169314A1
公开(公告)日：2019-09-06
申请号：PCT/US2019/020374
申请日：2019-03-01
Applicant: IGM BIOSCIENCES, INC.
Inventor： BALIGA, Ramesh , KEYT, Bruce Alan , NG, Dean
IPC: A61K39/395 , C07K16/46
Abstract: This disclosure provides an IgM antibody or IgM-like antibody comprising a variant J-chain and/or variant IgM heavy chain constant regions that can confer increased serum half-life upon the antibody.
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公开(公告)号：WO2018017761A1
公开(公告)日：2018-01-25
申请号：PCT/US2017/042931
申请日：2017-07-19
Applicant: IGM BIOSCIENCES, INC.
Inventor： KEYT, Bruce Alan , BALIGA, Ramesh , WANG, Beatrice Tien-Yi
Abstract: This disclosure provides dimeric, pentameric, and hexameric CD137/4-1BB agonist binding molecules and methods of using such binding molecules to induce anti-tumor immunity.
Abstract translation: 本公开提供了二聚体，五聚体和六聚体CD137 / 4-1BB激动剂结合分子以及使用此类结合分子诱导抗肿瘤免疫力的方法。
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Patent Agency Ranking
公开(公告)号：WO2017059387A1
公开(公告)日：2017-04-06
申请号：PCT/US2016/055053
申请日：2016-09-30
Applicant: IGM BIOSCIENCES, INC.
Inventor： KEYT, Bruce , PRESTA, Leonard George , BALIGA, Ramesh
CPC classification number: C07K16/2827 , C07K16/18 , C07K16/2809 , C07K16/2818 , C07K2317/31 , C07K2317/622 , C07K2317/732 , C07K2319/33 , C07K2319/735 , C07K2319/74
Abstract: The present invention provides binding molecules that include an IgM, IgA, IgG/IgM or IgG/IgA antibody with a modified J-chain that includes a binding moiety that antagonizes a T-cell inhibitory signaling pathway, and their uses.
Abstract translation: 本发明提供包含具有修饰的J链的IgM，IgA，IgG / IgM或IgG / IgA抗体的结合分子，其包括拮抗T细胞抑制性信号传导途径的结合部分及其用途。
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公开(公告)号：WO2023064766A1
公开(公告)日：2023-04-20
申请号：PCT/US2022/077904
申请日：2022-10-11
Applicant: IGM BIOSCIENCES, INC.
Inventor： FU, Tong-Ming , SHIVER, John, Wade
Abstract: This disclosure provides lateral flow devices comprising a sample loading section, a conjugate section, and an analysis section, wherein the conjugate section comprises a multimeric binding molecule that specifically binds to an analyte. Also provided are kits comprising such devices and methods of using and manufacturing such devices and kits.
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公开(公告)号：WO2021055765A2
公开(公告)日：2021-03-25
申请号：PCT/US2020/051513
申请日：2020-09-18
Applicant: IGM BIOSCIENCES, INC.
Inventor： BALIGA, Ramesh , HINTON, Paul , KEYT, Bruce
Abstract: This disclosure provides a multimeric binding molecule, e.g., an IgM, IgM-like, IgA, or IgA-like binding molecule, e.g., an antibody with enhanced selectivity for cells expressing a target antigen at high density, e.g., tumor cells. Enhanced selectivity can be achieved, e.g., through modulation of binding affinity for the target antigen and/or through adjusting avidity via multimeric antigen binding.
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公开(公告)号：WO2020086745A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/057702
申请日：2019-10-23
Applicant: IGM BIOSCIENCES, INC.
Inventor： BALIGA, Ramesh , HINTON, Paul , NG, Dean , KEYT, Bruce
IPC: A61K39/395 , C07K16/28 , C07K14/705
Abstract: This disclosure provides IgM-and IgA-derived binding molecules comprising binding polypeptides, e.g ., receptor ectodomains, ligands, or receptor-binding fragments thereof, and the like, fused to multimerizing IgM or IgA constant regions.
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公开(公告)号：WO2017196867A1
公开(公告)日：2017-11-16
申请号：PCT/US2017/031791
申请日：2017-05-09
Applicant: IGM BIOSCIENCES, INC.
Inventor： KEYT, Bruce , PRESTA, Leonard George , BALIGA, Ramesh
IPC: C07K16/28 , A61K39/395
Abstract: Aspects of the invention include isolated anti-PD-L1 antibodies, as well as compositions containing such antibodies, and methods of using the same in the treatment of diseases or conditions that are mediated by PD-L1 signaling.
Abstract translation: 本发明的方面包括分离的抗PD-L1抗体，以及含有这些抗体的组合物，以及使用它们治疗由PD-L1信号传导介导的疾病或病症的方法
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