公开(公告)号：WO2018153960A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054343

申请日：2018-02-22

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LINDH, Emma ,  WALLIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07H17/08 ,  A61K31/7048 ,  A61K31/7052 ,  A61P37/04 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18

Abstract: The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in the claims. The macrolides have utility in treating viral diseases and cancer.

公开(公告)号：WO2018153959A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054342

申请日：2018-02-22

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LINDH, Emma ,  WALLIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07H17/08 ,  A61K31/7048 ,  A61K31/7052 ,  A61P37/04 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18

Abstract: The present invention provides immune stimulating macrolides of formula (I), wherein the substituents are as defined in claim 1. The macrolides have utility in treating intracellular bacterial, fungal, and protozoal infections.

公开(公告)号：WO2018134370A1

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051345

申请日：2018-01-19

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LIND, Emma ,  WALIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07K7/23 ,  A61K38/02

Abstract: The present invention provides immune stimulating peptides (immunorhelins) capable of stimulating GnRH receptors when dosed to human patients or cells. These immunorhelins have utility in treating viral diseases and cancer.

公开(公告)号：WO2019180265A1

公开(公告)日：2019-09-26

申请号：PCT/EP2019/057364

申请日：2019-03-25

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola

IPC: A61K31/7048 ,  A61K31/7052 ,  A61K39/395 ,  A61K45/06 ,  C07H17/08 ,  A61P37/04 ,  A61P35/00 ,  A61P31/12

Abstract: The present invention provides a combination of immune stimulating macrolides with checkpoint inhibitors. The combinations have synergistic effects and can be used in treating viral diseases and cancer.

公开(公告)号：WO2018134372A1

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051347

申请日：2018-01-19

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LINDH, Emma ,  WALLIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: A61K38/09 ,  A61K31/565 ,  A61K31/568 ,  A61K31/57 ,  A61P31/04

Abstract: The present invention provides a method of treating intracellular infections, in particular intracellular bacterial, fungal, and protozoal infections.

公开(公告)号：WO2022049260A1

公开(公告)日：2022-03-10

申请号：PCT/EP2021/074399

申请日：2021-09-03

Applicant: ISR IMMUNE SYSTEM REGULATION HOLDING AB (PUBL)

Inventor： WINQVIST, Ola ,  SJÖDAHL, Johan

IPC: A61K31/7048 ,  A61K39/215 ,  A61K31/07 ,  A61K45/06 ,  A61P31/14

Abstract: The present invention provides vaccine kits and a method for vaccination using such vaccination kits.

公开(公告)号：WO2018153961A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054347

申请日：2018-02-22

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LUNDGREN, Yen

IPC: A61K38/09 ,  A61K31/568 ,  A61K31/4178 ,  A61P37/04 ,  A61P31/12 ,  A61P31/18

Abstract: The present invention relates to the use of a gonadotropin-releasing hormone (including GnRH I, a GnRH I analogue, GnRH II, or a GnRH II analogue) as adjuvant immunotherapeutic.

公开(公告)号：WO2018153957A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054340

申请日：2018-02-22

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LINDH, Emma ,  WALLIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07H17/08 ,  A61K31/7052 ,  A61P37/04 ,  A61P33/00 ,  A61P31/04

Abstract: The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating intracellular bacterial, fungal, and protozoal infections.

公开(公告)号：WO2018153954A1

公开(公告)日：2018-08-30

申请号：PCT/EP2018/054336

申请日：2018-02-22

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  WALLIN, Robert ,  LINDH, Emma ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07H17/08 ,  A61K31/7052 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04

Abstract: The present invention provides immune stimulating macrolide of formula (I). The macrolide has utility in treating viral diseases and cancer.

公开(公告)号：WO2018134373A1

公开(公告)日：2018-07-26

申请号：PCT/EP2018/051348

申请日：2018-01-19

Applicant: IMMUNE SYSTEM REGULATION HOLDING AB

Inventor： WINQVIST, Ola ,  LINDH, Emma ,  WALLIN, Robert ,  GREGORY, Matt ,  MOSS, Steven

IPC: C07K7/23 ,  A61K38/00

Abstract: The present invention provides immune stimulating peptides (immunorhelins) capable of activating GnRH receptors when administered to animal or human patients or cells. These immunorhelins have utility in treating intracellular bacterial, fungal, and protozoal infections.