公开(公告)号：WO2016102576A1

公开(公告)日：2016-06-30

申请号：PCT/EP2015/080991

申请日：2015-12-22

申请人： CONSIGLIO NAZIONALE DELLE RICERCHE ,  ISTITUTO NAZIONALE ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO

发明人： CATALUCCI, Daniele ,  MIRAGOLI, Michele ,  IAFISCO, Michele ,  TAMPIERI, Anna

IPC分类号： A61K9/14 ,  A61K9/51

CPC分类号： A61K9/5115 ,  A61K9/007 ,  A61K9/143 ,  A61K9/5192 ,  A61K31/7105 ,  A61K38/03 ,  A61K47/52 ,  A61K47/6929 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/32

摘要： The invention relates to a process for the preparation of a product comprising one or more nanoparticles of calcium phosphate (CaP-NP) with negative surface charge having a ζ-potential in the range from -41.0 mV to -27.0 mV comprising the steps of: a) maintaining a mixture having a pH in the range from 7 to 10 and comprising an aqueous solution of calcium, an aqueous solution of phosphate and a solution of citrate ions at a temperature in the range from 20 °C to 40 °C for a time in the range from 30 seconds to 10 minutes; b) removing non-reacted ions from the solution of step a), thus obtaining a suspension of one or more nanoparticles of calcium phosphate (CaP-NP); c) recovering the product of one or more nanoparticles of calcium phosphate (CaP-NP) from the suspension of step b). In an advantageous embodiment, the process of the invention provides, in the mixture of step a), also an aqueous solution of one or more therapeutic/diagnostic compounds. The product of the invention may be used as a vehicle for one or more diagnostic/therapeutic compounds for the treatment of cardiovascular diseases through inhalation administration.

摘要翻译： 本发明涉及一种制备包含一种或多种具有负电荷的磷酸钙（CaP-NP）的纳米颗粒的产品的方法，所述磷酸钙（CaP-NP）具有-41.0mV至-27.0mV范围内的ζ电位，包括以下步骤： a）保持pH在7至10范围内的混合物，并在20℃至40℃的温度范围内包含钙水溶液，磷酸盐水溶液和柠檬酸根离子溶液，用于 时间范围从30秒到10分钟; b）从步骤a）的溶液中除去未反应的离子，从而获得一种或多种磷酸钙（CaP-NP）纳米颗粒的悬浮液; c）从步骤b）的悬浮液中回收一种或多种磷酸钙（CaP-NP）纳米颗粒的产物。 在有利的实施方案中，本发明的方法在步骤a）的混合物中还提供一种或多种治疗/诊断化合物的水溶液。 本发明的产品可以用作一种或多种用于通过吸入给药治疗心血管疾病的诊断/治疗化合物的载体。

公开(公告)号：WO2017009759A1

公开(公告)日：2017-01-19

申请号：PCT/IB2016/054114

申请日：2016-07-08

申请人： FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA ,  INAIL - ISTITUTO NAZIONALE ASSICURAZIONE CONTRO GLI INFORTUNI SUL LAVORO

发明人： BIBOLOTTI, Alberto

IPC分类号： F16H7/02 ,  F16H1/46 ,  F16H9/26

CPC分类号： F16H1/46 ,  F02B67/06 ,  F05B2260/40311 ,  F16G1/28 ,  F16H7/02 ,  F16H7/023 ,  F16H9/26 ,  F16H57/082 ,  F16H2001/2881 ,  F16H2007/0865

摘要： The present invention relates to an epicyclic speed reducer (1), comprising a casing (4) comprising a first (2a) and a second opening (2b) arranged on opposite faces of said casing (4). The casing (4) houses inside it: a first sun gear (20) fastened inside the casing (4) at said first opening (2a); a second sun gear (30) coaxial with the first sun gear (20) with the axis passing from the first opening (2a) to the second opening (2b); a first planet gear (8a, 8b) adapted to describe a circular orbit around the first sun gear (20); a second planet gear (9a, 9b) adapted to describe a circular orbit around the second sun gear (30); a supporting element (5) interposed between the first (20) and second (30) sun gear and adapted to rotate around the axis, the supporting element (5) connected to the first (8a, 8b) and second (9a, 9b) planet gear in such a way as to allow a relative rotation of the supporting element (5) with respect to the first (8a, 8b) and second (9a, 9b) planet gear; a first belt (10) connected to the first planet gear (8a, 8b) and to the first sun gear (20); a second belt (11) connected to the second planet gear (9a, 9b) and to the second sun gear (30). Moreover the supporting element (5) is provided with a seat (21) coaxial with the axis and adapted to be fitted on one end (2) of a driving shaft such that when the seat is fitted on the driving shaft the supporting element (5) and the driving shaft are rigidly connected.

摘要翻译： 本发明涉及一种行星减速器（1），其包括壳体（4），其包括布置在所述壳体（4）的相对面上的第一（2a）和第二开口（2b）。 壳体（4）容纳在其内部：在所述第一开口（2a）处紧固在壳体（4）内的第一太阳齿轮（20）; 与所述第一太阳齿轮（20）同轴的第二太阳齿轮（30），所述轴线从所述第一开口（2a）延伸到所述第二开口（2b）; 适于描述围绕第一太阳齿轮（20）的圆形轨道的第一行星齿轮（8a，8b）; 适于描述围绕第二太阳齿轮（30）的圆形轨道的第二行星齿轮（9a，9b）; 插入在第一（20）和第二（30）太阳齿轮之间并适于围绕轴线旋转的支撑元件（5），支撑元件（5）连接到第一（8a，8b）和第二（9a，9b） 行星齿轮以允许支撑元件（5）相对于第一（8a，8b）和第二（9a，9b）行星齿轮相对旋转的方式; 连接到第一行星齿轮（8a，8b）和第一太阳齿轮（20）的第一带（10）; 连接到第二行星齿轮（9a，9b）和第二太阳齿轮（30）的第二皮带（11）。 此外，支撑元件（5）设置有与轴线同轴的座（21），并且适于安装在驱动轴的一端（2）上，使得当座椅装配在驱动轴上时，支撑元件（5） ）和驱动轴刚性连接。