公开(公告)号：WO2013007763A9

公开(公告)日：2013-03-21

申请号：PCT/EP2012063617

申请日：2012-07-11

Applicant: UNIV ZUERICH ,  JANKOVIC DRAGANA ,  KISTOWSKA MAGDALENA ,  CONTASSOT EMMANUEL ,  FRENCH LARS E ,  GEHRKE SAMUEL

Inventor： JANKOVIC DRAGANA ,  KISTOWSKA MAGDALENA ,  CONTASSOT EMMANUEL ,  FRENCH LARS E ,  GEHRKE SAMUEL

IPC: C07K16/24 ,  A61K31/64 ,  A61K31/7088 ,  A61P17/10 ,  C07K16/28

CPC classification number: A61K38/2006 ,  A61K31/50 ,  A61K31/64 ,  A61K2039/505 ,  C07K16/245 ,  C07K16/2866 ,  G01N33/6869

Abstract: The invention provides inhibitors capable of binding to a member of the inflammasome group comprised of IL-1 beta, IL-1 receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B with a dissociation constant of 10-8 mol/l or smaller for the prevention and treatment of acne, specifically an antibody, an antibody fragment, an antibody-like molecule, an oligopeptide of 6 to 30 amino acid residues, a nucleic acid aptamer molecule of 10 to 75 nucleotides in length or a soluble polypeptide comprising a contiguous amino acid sequence of at least 30 amino acids comprised within the protein sequence of a member of the group comprised of IL-1 beta, IL-1 receptor type 1, IL-1 receptor type 2, NLRP3, ASC and Caspase-1. Similarly, an interfering RNA or an antisense modulator of gene expression of IL-1 beta, I L-1 beta receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B are provided for the prevention or treatment of acne.

Abstract translation: 本发明提供了能够与解离常数为10-8mol / l的IL-1β，IL-1受体1型，NLRP3，ASC，Caspase-1和组织蛋白酶B结合的炎症小组成员的抑制剂，或 较小的预防和治疗痤疮，特别是抗体，抗体片段，抗体样分子，6至30个氨基酸残基的寡肽，长度为10至75个核苷酸的核酸适体分子或可溶性多肽，其包含 包含IL-1β，IL-1受体1型，IL-1受体2型，NLRP3，ASC和半胱天冬酶-1的成员的蛋白质序列内的至少30个氨基酸的连续氨基酸序列 。 类似地，提供了用于预防或治疗痤疮的干扰RNA或IL-1β，I L-1β受体1型，NLRP3，ASC，Caspase-1和组织蛋白酶B的基因表达的反义调节剂。

公开(公告)号：WO2013007763A1

公开(公告)日：2013-01-17

申请号：PCT/EP2012/063617

申请日：2012-07-11

Applicant: UNIVERSITÄT ZÜRICH ,  JANKOVIC, Dragana ,  KISTOWSKA, Magdalena ,  CONTASSOT, Emmanuel ,  FRENCH, Lars. E. ,  GEHRKE, Samuel

Inventor： JANKOVIC, Dragana ,  KISTOWSKA, Magdalena ,  CONTASSOT, Emmanuel ,  FRENCH, Lars. E. ,  GEHRKE, Samuel

IPC: C07K16/24 ,  C07K16/28 ,  A61K31/64 ,  A61P17/10 ,  A61K31/7088

CPC classification number: A61K38/2006 ,  A61K31/50 ,  A61K31/64 ,  A61K2039/505 ,  C07K16/245 ,  C07K16/2866 ,  G01N33/6869

Abstract: The invention provides inhibitors capable of binding to a member of the inflammasome group comprised of IL-1 β, IL-1 receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B with a dissociation constant of 10 -8 mol/l or smaller for the prevention and treatment of acne, specifically an antibody, an antibody fragment, an antibody-like molecule, an oligopeptide of 6 to 30 amino acid residues, a nucleic acid aptamer molecule of 10 to 75 nucleotides in length or a soluble polypeptide comprising a contiguous amino acid sequence of at least 30 amino acids comprised within the protein sequence of a member of the group comprised of IL-1 β, IL-1 receptor type 1, IL-1 receptor type 2, NLRP3, ASC and Caspase-1. Similarly, an interfering RNA or an antisense modulator of gene expression of IL-1 β, I L-1 β receptor type 1, NLRP3, ASC, Caspase-1 and cathepsin B are provided for the prevention or treatment of acne.

Abstract translation: 本发明提供能够以10-8mol / l的解离常数与IL-1β，IL-1受体1型，NLRP3，ASC，Caspase-1和组织蛋白酶B结合的炎症小组成员的抑制剂，或 较小的预防和治疗痤疮，特别是抗体，抗体片段，抗体样分子，6至30个氨基酸残基的寡肽，长度为10至75个核苷酸的核酸适体分子或可溶性多肽，其包含 包含IL-1β，IL-1受体1型，IL-1受体2型，NLRP3，ASC和Caspase-1的成员的蛋白质序列内的至少30个氨基酸的连续氨基酸序列 。 类似地，提供IL-1β，I-L-1β受体1型，NLRP3，ASC，Caspase-1和组织蛋白酶B的基因表达的干扰RNA或反义调节剂用于预防或治疗痤疮。