公开(公告)号：WO2009153806A2

公开(公告)日：2009-12-23

申请号：PCT/IN2009000274

申请日：2009-05-08

申请人： SAIRAM ORGANICS PVT LTD ,  PHARMACEUTICAL SOLUTIONS FZCO ,  JAUHARI PRADEEP KUMAR

发明人： JAUHARI PRADEEP KUMAR

IPC分类号： C07C209/62 ,  C07C209/84

CPC分类号： C07C209/62 ,  C07C209/84 ,  C07C2603/74 ,  C07C211/38

摘要： A process for preparing memantine hydrochloride free from impurities comprises (a) reacting 1,3-dimethyladarnantane with acetontitrile and sulphuric acid to produce 1- acetamido-3,5-dimethyl adamantane; (b) treating l-acetamido-3,5-dimethyl adamantane with base in the presence of solvent to produce memantine; (c) reacting memantine with alcoholic HCl in the presence of solvents to produce memantine hydrochloride; and purification of memantine hydrochloride using aliphatic solvents.

摘要翻译： 一种不含杂质的美金刚盐酸盐的制备方法包括（a）使1,3-二甲基十一烷与丙腈和硫酸反应生成1-乙酰氨基-3,5-二甲基金刚烷; （b）在溶剂存在下用碱处理1-乙酰氨基-3,5-二甲基金刚烷，生成美金刚; （c）在溶剂存在下将美金刚与醇HCl反应生产美金刚盐酸盐; 并使用脂族溶剂纯化美金刚盐酸盐。

公开(公告)号：WO2009153806A3

公开(公告)日：2009-12-23

申请号：PCT/IN2009/000274

申请日：2009-05-08

申请人： SAIRAM ORGANICS PVT. LTD. ,  PHARMACEUTICAL SOLUTIONS FZCO ,  JAUHARI, Pradeep, Kumar

发明人： JAUHARI, Pradeep, Kumar

IPC分类号： C07C209/62 ,  C07C209/84 ,  C07C211/38

摘要： A process for preparing memantine hydrochloride free from impurities comprises (a) reacting 1,3-dimethyladamantane with acetonitrile and sulphuric acid to produce 1 - acetamido-3,5- dimethyl adamantane; (b) treating 1-acetamido-3,5-dimethyl adamantane with base in the presence of solvent to produce memantine; (c) reacting memantine with alcoholic HCI in the presence of solvents to produce memantine hydrochloride; and purification of memantine hydrochloride using aliphatic solvents.