公开(公告)号：WO2006121861A3

公开(公告)日：2006-11-16

申请号：PCT/US2006/017412

申请日：2006-05-05

Applicant: MICROBIA, INC. ,  ANTONELLI, Stephen ,  LUNDIGRAN-SOUCY, Regina ,  MARTINEZ, Eduardo J. ,  SCHAIRER, Wayne C. ,  TALLEY, John J. ,  BARDEN, Timothy C. ,  JING-JING, Yang ,  ZIMMER, Daniel P.

Inventor： ANTONELLI, Stephen ,  LUNDIGRAN-SOUCY, Regina ,  MARTINEZ, Eduardo J. ,  SCHAIRER, Wayne C. ,  TALLEY, John J. ,  BARDEN, Timothy C. ,  JING-JING, Yang ,  ZIMMER, Daniel P.

IPC: C07D205/08 ,  C07F9/568 ,  C07H7/04 ,  C07H15/18 ,  C07H15/203 ,  A61K31/395 ,  A61P3/06 ,  A61P9/12 ,  A61P25/28 ,  A61P3/10

Abstract: The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.

公开(公告)号：WO2006121861A2

公开(公告)日：2006-11-16

申请号：PCT/US2006017412

申请日：2006-05-05

Applicant: MICROBIA INC ,  ANTONELLI STEPHEN ,  LUNDIGRAN-SOUCY REGINA ,  MARTINEZ EDUARDO J ,  SCHAIRER WAYNE C ,  TALLEY JOHN J ,  BARDEN TIMOTHY C ,  JING-JING YANG ,  ZIMMER DANIEL P

Inventor： ANTONELLI STEPHEN ,  LUNDIGRAN-SOUCY REGINA ,  MARTINEZ EDUARDO J ,  SCHAIRER WAYNE C ,  TALLEY JOHN J ,  BARDEN TIMOTHY C ,  JING-JING YANG ,  ZIMMER DANIEL P

IPC: A61K31/519 ,  A61K31/522

CPC classification number: C07D205/08 ,  C07D405/10 ,  C07F9/568 ,  C07F9/65586 ,  C07H7/04 ,  C07H15/203

Abstract: The invention relates to a chemical genus of 4-biphenyl-1-phenylazetidin-2-ones useful in the treatment of hypercholesterolemia and other disorders. The compounds have the general formula (I). Pharmaceutical compositions and methods for treating cholesterol- and lipid-associated diseases are also disclosed.

Abstract translation: 本发明涉及可用于治疗高胆固醇血症和其他疾病的4-联苯-1-苯基氮杂环丁烷-2-酮的化学属。 化合物具有通式（I）。 还公开了用于治疗胆固醇和脂质相关疾病的药物组合物和方法。