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    TRAPPED CELLS AND USE THEREOF AS A DRUG
    4.
    发明申请
    TRAPPED CELLS AND USE THEREOF AS A DRUG 审中-公开
    TRAPPED细胞和作为药物使用

    公开(公告)号：WO1993008843A1

    公开(公告)日：1993-05-13

    申请号：PCT/FR1992001016

    申请日：1992-10-30

    Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) ,  KLATZMANN, David

    Inventor： UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI)

    IPC: A61K48/00

    CPC classification number: A61K35/28 ,  A61K48/00

    Abstract: Cells, esp. haematopoietic cells, which are trapped with regard to activation, by an antigen (Ag), against which tolerance of the host (animal or human) immune system is sought, contain a genetic sequence (I), the expression product (II) of which, when produced at a high level in the cells, reacts in situ with a pharmaceutically active substance (III) to induce cell destruction. The cell also includes elements, specifically induced by an activation signal provided by Ag, so as to cause high level prodn. of (II). Pref. (I) and the necessary control elements are present on a recombinant DNA fragment specifically, the elements are those which normally control expression of a cytokine (esp. IL-2) or the corresponding receptor. (III) cause, directly or indirectly, interruption of cellular DNA replication.

    METHODES D'IDENTIFICATION ET DE PREPARATION DE LYMPHOCYTES T REGULATEURS/SUPPRESSEURS, COMPOSITIONS ET UTILISATIONS
    5.
    发明申请
    METHODES D'IDENTIFICATION ET DE PREPARATION DE LYMPHOCYTES T REGULATEURS/SUPPRESSEURS, COMPOSITIONS ET UTILISATIONS 审中-公开

    公开(公告)号：WO2005063969A3

    公开(公告)日：2005-07-14

    申请号：PCT/FR2004/003374

    申请日：2004-12-23

    Applicant: ASSISTANCE PUBLIQUE, HOPITAUX DE PARIS ,  KLATZMANN, David ,  LEMOINE, François

    Inventor： KLATZMANN, David ,  LEMOINE, François

    IPC: C12N5/06

    Abstract: La présente invention concerne les domaines de la biologie, de la génétique et de la médecine. L'invention décrit des méthodes et compositions permettant (1) l'identification de cellules ou lymphocytes T suppresseurs (Ts) ou leurs précurseurs (pTs) à des fins diagnostiques et thérapeutiques et pour la réalisation d'études génomiques et protéomiques, notamment pour l'identification de nouveaux marqueurs et/ou cibles thérapeutiques pour ces cellules ; (2) la production de cellules ou lymphocytes T suppresseurs (Ts) ou leurs précurseurs (pTs) et/ou leurs manipulations in vivo ou ex vivo pour contrôler des conditions pathologiques variées, incluant des maladies associées à une activité anormale des lymphocytes effecteurs et/ou régulateurs. L'invention concerne la préparation de telles compositions à base de lymphocytes Ts et pTs, et leur utilisation dans le cadre de thérapies cellulaires. Les compositions ou populations cellulaires à base de lymphocytes Ts et pTs obtenues dans le cadre de l'invention sont en particulier adaptées au traitement des tumeurs, des maladies auto­ immunes, des allergies, de la maladie du greffon contre l'hôte, des effets greffe contre infection (GVI) ou greffe contre leucémie (GVL), des maladies inflammatoires, du diabète de type I, des infections virales, bactériennes ou parasitaires, à la reconstitution immune ou à l'induction d'une tolérance en cas de transplantation de cellules souches, tissus ou organe chez un mammifère.

    METHODS FOR THE IDENTIFICATION AND PREPARATION OF REGULATOR/SUPPRESSOR T LYMPHOCYTES, COMPOSITIONS AND USES THEREOF
    6.
    发明申请
    METHODS FOR THE IDENTIFICATION AND PREPARATION OF REGULATOR/SUPPRESSOR T LYMPHOCYTES, COMPOSITIONS AND USES THEREOF 审中-公开
    鉴定和制备调节剂/抑制剂T淋巴细胞，组合物及其用途的方法

    公开(公告)号：WO2005063969A2

    公开(公告)日：2005-07-14

    申请号：PCT/FR2004003374

    申请日：2004-12-23

    Applicant: ASSIST PUBL HOPITAUX DE PARIS ,  KLATZMANN DAVID ,  LEMOINE FRANCOIS

    Inventor： KLATZMANN DAVID ,  LEMOINE FRANCOIS

    IPC: A61K35/14 ,  C12N5/0783 ,  C12N5/08

    CPC classification number: C12N5/0636 ,  A61K2039/515

    Abstract: The invention relates to the fields of biology, genetics and medicine. The invention describes methods and compositions enabling (1) the identification of suppressor T cells or lymphocytes (Ts) or the precursors thereof (pTs) for diagnostic and therapeutical purposes and for carrying out genomic and proteomic studies, i.e. for the identification of new markers and/or therapeutical targets for said cells; (2) the production of of suppressor T cells or lymphocytes (Ts) or the precursors thereof (pTs) and/or the manipulations thereof in vivo or ex vivo for controlling various pathological conditions, including diseases associated with abnormal activity of effector and/or regulator lymphocytes. The invention relates to the preparation of said compositions based on Ts lymphocytes and pTS and to the use thereof in cell therapies. The compositions or cell populations based on the Ts lymphocytes and pTs obtained according to the invention are particularly suitable for the treatment of tumours, auto-immune diseases, allergies, graft-versus-host disease, graft versus infection effects (GVI) or graft-versus-leukemia effects (GVL), inflammatory diseases, type 1 diabetes, viral, bacterial or parasitic infections, for immune reconstruction or induction of tolerance in the event of transplantation of stem cells, tissue or organs in mammals.

    Abstract translation: 本发明涉及生物学，遗传学和医学领域。 本发明描述了能够（1）出于诊断和治疗目的鉴定抑制性T细胞或淋巴细胞（Ts）或其前体（pTs）并进行基因组学和蛋白质组学研究，即鉴定新标记物和 /或所述细胞的治疗靶点; （2）抑制性T细胞或淋巴细胞（Ts）或其前体（pTs）的产生和/或其体内或离体的操作，用于控制各种病理状态，包括与效应子和/或 调节淋巴细胞。 本发明涉及基于Ts淋巴细胞和pTS的所述组合物的制备及其在细胞疗法中的用途。 基于根据本发明获得的Ts淋巴细胞和pT的组合物或细胞群特别适用于治疗肿瘤，自身免疫疾病，变态反应，移植物抗宿主病，移植物抗感染效应（GVI）或移植物抗宿主病 （GVL），炎性疾病，1型糖尿病，病毒，细菌或寄生虫感染，用于在哺乳动物中移植干细胞，组织或器官的情况下免疫重建或诱导耐受性。

    TRANSFORMANT CELLS FOR THE PROPHYLAXIS OR TREATMENT OF DISEASES CAUSED BY VIRUSES, PARTICULARLY PATHOGENIC RETROVIRUSES
    8.
    发明申请
    TRANSFORMANT CELLS FOR THE PROPHYLAXIS OR TREATMENT OF DISEASES CAUSED BY VIRUSES, PARTICULARLY PATHOGENIC RETROVIRUSES 审中-公开
    用于预防或治疗病毒引起的疾病的转化细胞，特别致病性肝炎病毒

    公开(公告)号：WO1993008844A1

    公开(公告)日：1993-05-13

    申请号：PCT/FR1992001017

    申请日：1992-10-30

    Applicant: UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI) ,  KLATZMANN, David

    Inventor： UNIVERSITE PIERRE ET MARIE CURIE (PARIS VI)

    IPC: A61K48/00

    CPC classification number: C12N5/0634 ,  A61K48/00 ,  A61K2035/124 ,  C12N2510/00

    Abstract: A cell, particularly a hematopoietic cell population wherein the cells are trapped with respect to a given pathogenic virus having a tropism which is specific for said cells. Cells uninfected with the virus, particularly a retrovirus such as HIV, contain a genetic sequence of which the expression product (e.g. HSV1-TK-) may, when its production is increased so that it is present in a sufficient quantity within said trapped cells, react in situ with a pharmaceutically active substance (e.g. acyclovir in the above mentioned example) to induce the destruction of the cells and of means which are specifically induced by a signal provided by the pathogenic virus (e.g. the long terminal repeat of the retrovirus) when it enters the cells, to cause the aforesaid increased production. The use of said pharmaceutically active substance to produce active drugs preventing infection by said virus, is also described.

    Abstract translation: 一种细胞，特别是造血细胞群体，其中相对于具有对所述细胞特异性的向性的给定病原体病毒捕获细胞。 未感染病毒的细胞，特别是逆转录病毒例如HIV，含有表达产物（例如HSV1-TK-）的遗传序列，其生产增加时可以在所述被捕获的细胞内以足够的量存在， 与药物活性物质（例如上述实施例中的阿昔洛韦）原位反应以诱导细胞的破坏和由病原体病毒提供的信号（例如逆转录病毒的长末端重复）特异性诱导的手段） 它进入细胞，导致上述生产增加。 还描述了使用所述药物活性物质来产生预防所述病毒感染的活性药物。

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