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1.发明申请COMBINATION MOTIF IMMUNE STIMULATORY OLIGONUCLEOTIDES WITH IMPROVED ACTIVITY 审中-公开具有改善活性的组合动物免疫刺激性寡核苷酸
公开(公告)号：WO2009022215A8
公开(公告)日：2010-03-11
申请号：PCT/IB2008002102
申请日：2008-08-05
Applicant: PFIZER , COLEY PHARM GROUP INC , COLEY PHARM GMBH , UHLMANN EUGEN , KRIEG ARTHUR M , HANSON DOUGLAS CHARLES , SAMULOWITZ ULRIKE , VOLLMER JORG
Inventor： UHLMANN EUGEN , KRIEG ARTHUR M , HANSON DOUGLAS CHARLES , SAMULOWITZ ULRIKE , VOLLMER JORG
IPC: A61K31/7088 , C12N15/117
CPC classification number: A61K31/7088 , A61K39/39 , A61K2039/55561 , C12N15/117 , C12N2310/17 , C12N2310/31 , C12N2310/315
Abstract: lmmunostimulatory oligonucleotides, which contain a CpG immunostimulatory motif and a second motif that is capable of forming secondary structure, including duplex and higher order structures in vitro and./n vivo, are disclosed. They include nucleic acids, or pharmaceutically acceptable salts thereof, having base sequences that include 5' TCGTCGTTTTCGGCGCGCGCCGT 3' (SEQ ID NO: 1), in which each C is unmethylated and 3' refers to the 31 end of the nucleic acid. The oligonucleotides activate B cells and NK cells and induce expression of type I interferon and interferon-?. The oligonucleotides are useful for treating a variety of disorders and conditions, including allergy, asthma, infection, and cancer. In addition to their use as single agents and as combination therapies, the disclosed oligonucleotides are useful as adjuvants in vaccines.
Abstract translation: 公开了含有CpG免疫刺激基序和能够形成二级结构的第二基序的免疫刺激性寡核苷酸，包括体外和体内的双链体和高级结构。 它们包括具有包括5'TCGTCGTTTTCGGCGCGCGCCGT 3'（SEQ ID NO：1）的碱基序列的核酸或其药学上可接受的盐，其中每个C是未甲基化的，3'是指核酸的31个末端。 寡核苷酸激活B细胞和NK细胞并诱导I型干扰素和干扰素-α的表达。 寡核苷酸可用于治疗各种疾病和病症，包括过敏，哮喘，感染和癌症。 除了它们作为单一药剂和联合疗法的用途之外，所公开的寡核苷酸可用作疫苗中的佐剂。
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2.发明申请PEPTIDE-BASED VACCINE COMPOSITIONS TO ENDOGENOUS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) 审中-公开基于肽的内源性胆固醇酯转运蛋白（CETP）疫苗组合物
公开(公告)号：WO2008057529A3
公开(公告)日：2008-12-24
申请号：PCT/US2007023353
申请日：2007-11-06
Applicant: COLEY PHARM GROUP INC , AVANT IMMUNOTHERAPEUTICS INC , RITTERSHAUS CHARLES W , THOMAS LAWRENCE J , KRIEG ARTHUR M
Inventor： RITTERSHAUS CHARLES W , THOMAS LAWRENCE J , KRIEG ARTHUR M
CPC classification number: A61K39/0012 , A61K2039/55505 , A61K2039/55561 , C07K14/47 , C07K2319/00
Abstract: Improved vaccine compositions and methods of use thereof are described that elicit production of antibodies in an individual to the individual's own endogenous cholesteryl ester transfer protein (CETP).
Abstract translation: 描述了改进的疫苗组合物及其使用方法，其引发个体中对个体自身内源性胆固醇酯转移蛋白（CETP）产生抗体。
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3.发明申请MODULATION OF TLR-MEDIATED IMMUNE RESPONSES USING ADAPTOR OLIGONUCLEOTIDES 审中-公开调节TLR介导的免疫应答使用适配器寡核苷酸
公开(公告)号：WO2007038720A3
公开(公告)日：2007-06-21
申请号：PCT/US2006037987
申请日：2006-09-27
Applicant: COLEY PHARM GMBH , COLEY PHARM GROUP INC , JURK MARION , VOLLMER JOERG , KRIEG ARTHUR M , UHLMANN EUGEN , NOLL BERNHARD O
Inventor： JURK MARION , VOLLMER JOERG , KRIEG ARTHUR M , UHLMANN EUGEN , NOLL BERNHARD O
IPC: A61K45/06 , A61K31/7115 , A61K31/7125 , G01N33/68
CPC classification number: A61K31/7115 , A61K31/7125 , A61K45/06 , A61K47/549 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2320/31
Abstract: The invention relates to the ability of certain oligonucleotides to modify the profile of TLR ligands such as TLR7, TLR8 and TLR9 ligands.
Abstract translation: 本发明涉及某些寡核苷酸修饰TLR配体如TLR7，TLR8和TLR9配体分布的能力。
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公开(公告)号：WO2006135434A3
公开(公告)日：2007-05-10
申请号：PCT/US2005037731
申请日：2005-10-20
Applicant: COLEY PHARM GROUP INC , COLEY PHARM GMBH , KRIEG ARTHUR M , SAMULOWITZ ULRIKE , VOLLMER JORG , UHLMANN EUGEN
Inventor： KRIEG ARTHUR M , SAMULOWITZ ULRIKE , VOLLMER JORG , UHLMANN EUGEN
IPC: A61K9/00 , A61K31/7125 , C12N15/117
CPC classification number: C12N15/117 , A61K9/0043 , A61K9/0073 , A61K39/39 , A61K2039/55561 , C07H21/02 , C12N2310/17 , C12N2310/315 , C12N2310/345
Abstract: The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infectious disease, such as hepatitis B and hepatitis C.
Abstract translation: 本发明涉及可用于刺激免疫应答的特异性C-class半软CpG免疫刺激性寡核苷酸。 特别地，寡核苷酸可用于治疗过敏，例如过敏性鼻炎和哮喘，癌症和感染性疾病，例如乙型肝炎和丙型肝炎。
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5.发明申请MODULATION OF TLR-MEDIATED IMMUNE RESPONSES USING ADAPTOR OLIGONUCLEOTIDES 审中-公开使用适配器寡核苷酸调节TLR介导的免疫应答
公开(公告)号：WO2007038720A2
公开(公告)日：2007-04-05
申请号：PCT/US2006/037987
申请日：2006-09-27
Applicant: COLEY PHARMACEUTICAL GMBH , COLEY PHARMACEUTICAL GROUP, INC. , JURK, Marion , VOLLMER, Joerg , KRIEG, Arthur, M. , UHLMANN, Eugen , NOLL, Bernhard, O.
Inventor： JURK, Marion , VOLLMER, Joerg , KRIEG, Arthur, M. , UHLMANN, Eugen , NOLL, Bernhard, O.
CPC classification number: A61K31/7115 , A61K31/7125 , A61K45/06 , A61K47/549 , C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2320/31
Abstract: The invention relates to the ability of certain oligonucleotides to modify the profile of TLR ligands such as TLR7, TLR8 and TLR9 ligands.
Abstract translation: 本发明涉及某些寡核苷酸修饰TLR配体如TLR7，TLR8和TLR9配体的分布的能力。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2004094671A9
公开(公告)日：2005-01-27
申请号：PCT/US2004012788
申请日：2004-04-22
Applicant: COLEY PHARM GMBH , COLEY PHARM GROUP INC , VOLLMER JOERG , JURK MARION , LIPFORD GRAYSON B , SCHETTER CHRISTIAN , FORSBACH ALEXANDRA , KRIEG ARTHUR M
Inventor： VOLLMER JOERG , JURK MARION , LIPFORD GRAYSON B , SCHETTER CHRISTIAN , FORSBACH ALEXANDRA , KRIEG ARTHUR M
IPC: C07K14/705 , C12Q1/68
CPC classification number: C07K14/705
Abstract: The invention provides in part novel screening methods and compositions for identifying and distinguishing between candidate immunomodulatory compounds. The invention further provides methods for assessing biological activity of composition containing a known TLR ligand. These latter methods can be used for quality assessment and selection of various lots of test compositions, including pharmaceutical products for clinical use.
Abstract translation: 本发明部分提供了用于鉴定和鉴别候选免疫调节化合物的新型筛选方法和组合物。 本发明还提供了评估含有已知TLR配体的组合物的生物学活性的方法。 这些后一种方法可用于各种批次的测试组合物的质量评估和选择，包括用于临床应用的药物产品。
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7.发明申请
公开(公告)号：WO2004094671A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/012788
申请日：2004-04-22
Applicant: COLEY PHARMACEUTICAL GmbH , COLEY PHARMACEUTICAL GROUP, INC. , VOLLMER, Jörg , JURK, Marion , LIPFORD, Grayson, B. , SCHETTER, Christian , FORSBACH, Alexandra , KRIEG, Arthur, M.
Inventor： VOLLMER, Jörg , JURK, Marion , LIPFORD, Grayson, B. , SCHETTER, Christian , FORSBACH, Alexandra , KRIEG, Arthur, M.
IPC: C12Q1/68
CPC classification number: C07K14/705
Abstract: The invention provides in part novel screening methods and compositions for identifying and distinguishing between candidate immunomodulatory compounds. The invention further provides methods for assessing biological activity of composition containing a known TLR ligand. These latter methods can be used for quality assessment and selection of various lots of test compositions, including pharmaceutical products for clinical use.
Abstract translation: 本发明部分提供了用于鉴定和鉴别候选免疫调节化合物的新型筛选方法和组合物。 本发明还提供了评估含有已知TLR配体的组合物的生物学活性的方法。 这些后一种方法可用于各种批次的测试组合物的质量评估和选择，包括用于临床应用的药物产品。
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公开(公告)号：WO2008142509A2
公开(公告)日：2008-11-27
申请号：PCT/IB2008/001199
申请日：2008-05-15
Applicant: COLEY PHARMACEUTICAL GROUP, INC. , COLEY PHARMACEUTICAL GMBH , KRIEG, Arthur, M. , UHLMANN, Eugen , VOLLMER, Jörg
Inventor： KRIEG, Arthur, M. , UHLMANN, Eugen , VOLLMER, Jörg
IPC: A61K39/39
CPC classification number: A61K39/39 , A61K2039/55561
Abstract: The invention provides an immunostimulatory nucleic acid comprising CpG motifs, and methods of use thereof in stimulating immunity.
Abstract translation: 本发明提供了包含CpG基序的免疫刺激性核酸及其在刺激免疫中的用途。
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9.发明申请PEPTIDE-BASED VACCINE COMPOSITIONS TO ENDOGENOUS CHOLESTERYL ESTER TRANSFER PROTEIN (CETP) 审中-公开基于肽的内源性胆固醇酯转运蛋白（CETP）疫苗组合物
公开(公告)号：WO2008057529A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/023353
申请日：2007-11-06
Applicant: COLEY PHARMACEUTICAL GROUP, INC. , AVANT IMMUNOTHERAPEUTICS, INC. , RITTERSHAUS, Charles, W. , THOMAS, Lawrence, J. , KRIEG, Arthur, M.
Inventor： RITTERSHAUS, Charles, W. , THOMAS, Lawrence, J. , KRIEG, Arthur, M.
IPC: A61K39/00
CPC classification number: A61K39/0012 , A61K2039/55505 , A61K2039/55561 , C07K14/47 , C07K2319/00 , Y02A50/466
Abstract: Improved vaccine compositions and methods of use thereof are described that elicit production of antibodies in an individual to the individual's own endogenous cholesteryl ester transfer protein (CETP).
Abstract translation: 描述了改进的疫苗组合物及其使用方法，其在个体中引发抗体产生个体自身的内源胆固醇酯转移蛋白（CETP）。
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公开(公告)号：WO2006110607A3
公开(公告)日：2006-10-19
申请号：PCT/US2006/013193
申请日：2006-04-10
Applicant: COLEY PHARMACEUTICAL GROUP, INC. , SANOFI-AVENTIS U.S.P. LLC , KRIEG, Arthur, M. , DE SANCTIS, George, Tilo , UNDERWOOD, Stephen, Leslie , JUPP, Raymond, Anthony , SCHMIDT, John, A., Jr.
Inventor： KRIEG, Arthur, M. , DE SANCTIS, George, Tilo , UNDERWOOD, Stephen, Leslie , JUPP, Raymond, Anthony , SCHMIDT, John, A., Jr.
IPC: A61K31/7088
Abstract: Methods for treating viral exacerbated asthma comprising administrating to an asthmatic subject an effective amount of a CpG oligonucleotide
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