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公开(公告)号：WO2013022262A2
公开(公告)日：2013-02-14
申请号：PCT/KR2012006269
申请日：2012-08-07
Applicant: SEOUL NAT UNIV HOSPITAL , PARK YOUNG BAE , KIM HYO SOO , KWON YOO WOOK , LEE SAH MIN , LEE HYUN CHAE , CHO YOUNG JIN , LEE SANG EUN , CHUNG JUN HO
Inventor： PARK YOUNG BAE , KIM HYO SOO , KWON YOO WOOK , LEE SAH MIN , LEE HYUN CHAE , CHO YOUNG JIN , LEE SANG EUN , CHUNG JUN HO
CPC classification number: C07K14/5759 , C07K2319/30
Abstract: The present invention relates to a human resistin receptor. More specifically, provided are a method for searching for a receptor for a human resistin protein, a method for preventing or treating inflammatory diseases and atherosclerosis using a regulator which regulates the expression or activity of a human resistin receptor, and a pharmaceutical composition containing a regulator which regulates the expression or activity of a human resistin receptor. It is possible to separate a receptor which directly binds to resistin from human monocytes using the method for searching for a receptor for a human resistin protein of the present invention, and the discovery of the signal delivery system of a resistin receptor is expected to contribute to the regulation of inflammatory effects of a monocyte, the diagnosis of the molecular cause of blood vessel inflammation and atherosclerosis, and the development of an agent for preventing and treating inflammatory diseases and atherosclerosis.
Abstract translation: 本发明涉及人抵抗素受体。 更具体而言，提供了用于检索人抵抗素蛋白的受体的方法，使用调节人抵抗素受体的表达或活性的调节剂来预防或治疗炎性疾病和动脉粥样硬化的方法，以及含有调节剂的药物组合物 其调节人抵抗素受体的表达或活性。 使用本发明的人抵抗素蛋白质受体的检索方法，可以将与人抵抗素直接结合的受体从人单核细胞中分离出来，发现抵抗素受体的信号传递系统有助于 单核细胞炎症作用的调节，血管炎症和动脉粥样硬化的分子病因的诊断，以及炎症性疾病和动脉粥样硬化的预防和治疗剂的开发。
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公开(公告)号：WO2013022262A3
公开(公告)日：2013-05-30
申请号：PCT/KR2012006269
申请日：2012-08-07
Applicant: SEOUL NAT UNIV HOSPITAL , PARK YOUNG BAE , KIM HYO SOO , KWON YOO WOOK , LEE SAH MIN , LEE HYUN CHAE , CHO YOUNG JIN , LEE SANG EUN , CHUNG JUN HO
Inventor： PARK YOUNG BAE , KIM HYO SOO , KWON YOO WOOK , LEE SAH MIN , LEE HYUN CHAE , CHO YOUNG JIN , LEE SANG EUN , CHUNG JUN HO
CPC classification number: C07K14/5759 , C07K2319/30
Abstract: The present invention relates to a human resistin receptor. More specifically, provided are a method for searching for a receptor for a human resistin protein, a method for preventing or treating inflammatory diseases and atherosclerosis using a regulator which regulates the expression or activity of a human resistin receptor, and a pharmaceutical composition containing a regulator which regulates the expression or activity of a human resistin receptor. It is possible to separate a receptor which directly binds to resistin from human monocytes using the method for searching for a receptor for a human resistin protein of the present invention, and the discovery of the signal delivery system of a resistin receptor is expected to contribute to the regulation of inflammatory effects of a monocyte, the diagnosis of the molecular cause of blood vessel inflammation and atherosclerosis, and the development of an agent for preventing and treating inflammatory diseases and atherosclerosis.
Abstract translation: 本发明涉及人抵抗素受体。 更具体地，提供了一种用于搜索人抵抗素蛋白的受体的方法，使用调节人体抵抗素受体的表达或活性的预防或治疗炎性疾病和动脉粥样硬化的方法，以及含有调节因子 其调节人抵抗素受体的表达或活性。 使用本发明的人抵抗素蛋白质的受体的检索方法，可以将与人单核细胞直接结合的受体分离到抗性蛋白质中，预期抵抗素受体的信号传递系统的发现有助于 调节单核细胞的炎症作用，诊断血管炎症和动脉粥样硬化的分子原因，以及发展用于预防和治疗炎性疾病和动脉粥样硬化的药物。
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3.发明申请HIGHLY-EFFICIENT MANUFACTURING METHOD OF INDUCED PLURIPOTENT STEM CELLS AND INDUCED PLURIPOTENT STEM CELLS PRODUCED BY THE METHOD 审中-公开用该方法制备的诱导性多功能干细胞和诱导性多功能干细胞的高效制备方法
公开(公告)号：WO2011037367A2
公开(公告)日：2011-03-31
申请号：PCT/KR2010006374
申请日：2010-09-17
Applicant: SEOUL NAT UNIV HOSPITAL , PARK YOUNG-BAE , KIM HYO-SOO , KWON YOO-WOOK , CHO HYUN-JAI , PAEK JAE-SEUNG
Inventor： PARK YOUNG-BAE , KIM HYO-SOO , KWON YOO-WOOK , CHO HYUN-JAI , PAEK JAE-SEUNG
CPC classification number: C12N5/0696 , A61K2035/124 , C12N2502/45
Abstract: The present invention relates to a method for manufacturing personalized pluripotent stem cells having the same differentiation potency as embryonic stem cells, which comprises the following steps: preparing protein extracts separated from various types of undifferentiated stem cells induced through a variety of methods (induced Pluripotent Stem cells, iPS); infusing the extracts into adult cells; and deriving pluripotent stem cells having the same differentiation potency as embryonic stem cells by culturing the adult cells infused with the extracts. In addition, the present invention relates to pluripotent stem cells produced by the method and cell therapy products that include pluripotent stem cells. In comparison to conventional manufacturing methods for pluripotent stem cells, the method of the present invention allows pluripotent stem cells to be produced with ease and remarkably high efficiency.
Abstract translation: 本发明涉及一种制造具有与胚胎干细胞相同的分化潜能的个性化多能干细胞的方法，其包括以下步骤：制备从各种类型的未分化干细胞分离的蛋白质提取物，所述未分化干细胞通过多种方法诱导（诱导多能干细胞 细胞，iPS）; 将提取物注入成体细胞; 并且通过培养灌输了提取物的成体细胞来衍生具有与胚胎干细胞相同的分化潜能的多能干细胞。 另外，本发明涉及通过该方法产生的多能干细胞和包含多能干细胞的细胞治疗产品。 与传统的多能干细胞制造方法相比，本发明的方法使得多能干细胞易于生产且效率显着提高。
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