公开(公告)号：WO2013059442A3

公开(公告)日：2015-06-18

申请号：PCT/US2012060794

申请日：2012-10-18

Applicant: BAYLOR COLLEGE MEDICINE ,  SONG XIAO-TONG ,  LEWIS DOROTHY E ,  ZHU WEI

Inventor： SONG XIAO-TONG ,  LEWIS DOROTHY E ,  ZHU WEI

IPC: C12N15/113 ,  A61K31/7088 ,  A61K39/21

CPC classification number: C12N15/1137 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55561 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16134 ,  C12N2799/027 ,  C12Y102/01036

Abstract: A method and vaccine composition compressing a siRNA and/or a shRNA that targets a retinoic acid producing enzyme and an antigen. Silencing retinoic acid producing enzymes downregulates α4β7 expression on activated T and B cells. Immunization with a retinoic acid silencing mechanism greatly enhanced anti-HIV gp140 immune responses in the vaginal tract and periphery but not in the intestine, providing a unique strategy to redistribute anti-HIV mucosal immune responses on the front line of defense against HIV-1 with concomitant suppression of α4β7high CD4+ T cells.

Abstract translation: 压缩靶向视黄酸生成酶和抗原的siRNA和/或shRNA的方法和疫苗组合物。 沉默视黄酸生成酶下调活化的T细胞和B细胞上的α4β7表达。 用视黄酸沉默机制的免疫大大增强了阴道和周边但不在肠道中的抗HIV gp140免疫应答，提供了将抗HIV粘膜免疫应答重新分布在针对HIV-1的防线前端的独特策略， 伴随抑制α4β7高CD4 + T细胞。

公开(公告)号：WO2010099184A1

公开(公告)日：2010-09-02

申请号：PCT/US2010/025209

申请日：2010-02-24

Applicant: BAYLOR COLLEGE OF MEDICINE ,  LEWIS, Dorothy, E. ,  OROZCO, Aaron, F. ,  BISCHOFF, Farideh, Z.

Inventor： LEWIS, Dorothy, E. ,  OROZCO, Aaron, F. ,  BISCHOFF, Farideh, Z.

IPC: G01N33/53 ,  G01N33/553

CPC classification number: G01N33/689 ,  G01N33/54313 ,  G01N33/54326

Abstract: The present disclosure provides methods of quantifying and isolating microparticles of fetal from maternal bodily fluids such as cell free maternal plasma. Antibodies or combinations of antibodies that selectively bind fetal microparticles in maternal bodily fluid permit quantification by flow cytometry and isolation through flow cytometry based sorting and immunopurification.

Abstract translation: 本公开提供了量化和分离胎儿与母体体液如无细胞母体血浆的微粒的方法。 在母体体液中选择性结合胎儿微粒的抗体或抗体的组合允许通过流式细胞术进行定量并通过基于流式细胞术的分选和免疫纯化进行分离。

公开(公告)号：WO2013059442A2

公开(公告)日：2013-04-25

申请号：PCT/US2012/060794

申请日：2012-10-18

Applicant: BAYLOR COLLEGE OF MEDICINE ,  SONG, Xiao-tong ,  LEWIS, Dorothy, E. ,  ZHU, Wei

Inventor： SONG, Xiao-tong ,  LEWIS, Dorothy, E. ,  ZHU, Wei

IPC: A61K48/00

CPC classification number: C12N15/1137 ,  A61K39/12 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/545 ,  A61K2039/55561 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16134 ,  C12N2799/027 ,  C12Y102/01036

Abstract: A method and vaccine composition compressing a siRNA and/or a shRNA that targets a retinoic acid producing enzyme and an antigen. Silencing retinoic acid producing enzymes downregulates α4β7 expression on activated T and B cells. Immunization with a retinoic acid silencing mechanism greatly enhanced anti-HIV gp140 immune responses in the vaginal tract and periphery but not in the intestine, providing a unique strategy to redistribute anti-HIV mucosal immune responses on the front line of defense against HIV-1 with concomitant suppression of α4β7high CD4+ T cells.

Abstract translation: 压缩靶向视黄酸生成酶和抗原的siRNA和/或shRNA的方法和疫苗组合物。 沉默视黄酸生成酶下调活化的T和B细胞上的α4β7表达。 视网膜酸沉默机制的免疫大大增强了阴道和周边但不在肠道中的抗HIV gp140免疫应答，提供了独特的策略，以将抗HIV粘膜免疫应答重新分布在针对HIV-1的防线前端， 伴随抑制α4β7高CD4 + T细胞。