公开(公告)号：WO2021202907A2

公开(公告)日：2021-10-07

申请号：PCT/US2021/025427

申请日：2021-04-01

申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN ,  SUN, Duxin ,  GAO, Wei ,  HU, Hongxiang ,  TRAORE, Mohamed Dit Mady ,  SONG, Yudong ,  WEN, Bo ,  HE, Miao ,  YUAN, Hebao ,  LI, Ruiting

发明人： SUN, Duxin ,  GAO, Wei ,  HU, Hongxiang ,  TRAORE, Mohamed Dit Mady ,  SONG, Yudong ,  WEN, Bo ,  HE, Miao ,  YUAN, Hebao ,  LI, Ruiting

IPC分类号： A61K31/015 ,  A61K31/135 ,  A61K31/165 ,  C07H19/06

摘要： The present invention relates to methods, compounds, and compositions for treating viral infections, including COVID-19 viral infections. In certain embodiments, the compositions comprise: i) a remdesivir analog, ii) remdesivir or a remdesivir analog, and a surfactant, a cyclodextrin, or a combination thereof, iii) nanoparticles comprising albumin and remdesivir or remdesivir analog, iv) liposomes comprising lipids and remdesivir or remdesivir analog; and/or v) microparticles comprising PLA and/or PLGA, and remdesivir or remdesivir analog. In certain embodiments, the compositions are aqueous (e.g., for intravenous administration). In other embodiments, the compositions are nebulized or in the form of a dry powder (e.g., for inhalation by an infected subject).