公开(公告)号：WO1997019973A1

公开(公告)日：1997-06-05

申请号：PCT/FR1996001901

申请日：1996-11-29

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  VERT, Michel ,  LI, Suming ,  RASHKOV, Iliya ,  ESPARTERO-SANCHEZ, José-Luis

Inventor： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

IPC: C08G63/66

CPC classification number: C08G63/00 ,  A61K47/34 ,  C08G63/66 ,  Y10S524/916

Abstract: A soft hydrogel containing a triblock copolymer and water is disclosed. The copolymer has formula (I): X-G-Y, wherein G is a non-hydroxylated hydrophilic linear polymer block containing p repetitive units, where p is a number from 10 to 150, each of X and Y is a polyester block containing m and n repetitive units, respectively, and the ratio (m + n)/p is high enough for said copolymer to be water-insoluble, said ratio (m + n)/p being selected in such a way that adding water to a solution of the copolymer in a water-miscible organic solvent leads to the formation of a soft hydrogel capable of retaining an amount of water at least as great as the weight of said copolymer. Said hydrogel is suitable for retaining and gradually releasing hydrophobic substances and/or hydrophilic macromolecules, including drugs.

Abstract translation: 公开了含有三嵌段共聚物和水的软水凝胶。 共聚物具有式（I）：XGY，其中​​G是含有p重复单元的非羟基化亲水直链聚合物嵌段，其中p为10至150的数，X和Y各自为含有m和n重复的聚酯嵌段 单位，并且所述共聚物的比例（m + n）/ p足够高，所述共聚物是不溶于水的，所述比例（m + n）/ p以这样的方式选择，即向共聚物溶液中加入水 在水可混溶的有机溶剂中导致形成软水凝胶，其能够保持至少与所述共聚物的重量一样大的水。 所述水凝胶适用于保留和逐渐释放疏水物质和/或亲水性大分子，包括药物。