公开(公告)号：WO2006079176A1

公开(公告)日：2006-08-03

申请号：PCT/AU2006/000102

申请日：2006-01-27

Applicant: APOLLO LIFE SCIENCES LIMITED ,  PRIEST, John, D. ,  WATTS, Alan, D. ,  WHITTAKER, Jason, S. ,  DOMAGALA, Teresa, A. ,  PILKINGTON, Glenn, R. ,  BOEHM, Ingrid ,  LEE, Carol, M., Y. ,  LIM, Mei, Ann ,  THOMAS, Nikolien, S.

Inventor： PRIEST, John, D. ,  WATTS, Alan, D. ,  WHITTAKER, Jason, S. ,  DOMAGALA, Teresa, A. ,  PILKINGTON, Glenn, R. ,  BOEHM, Ingrid ,  LEE, Carol, M., Y. ,  LIM, Mei, Ann ,  THOMAS, Nikolien, S.

IPC: C07K14/525 ,  A61K38/17 ,  A61K38/19 ,  A61K39/395 ,  A61K45/00 ,  A61P17/00 ,  C07H21/04 ,  C07K14/715 ,  C07K19/00 ,  G01N33/543

CPC classification number: C07K14/70575 ,  A61K38/191 ,  C07K14/525 ,  C07K14/5255 ,  G01N33/6863

Abstract: The present invention relates generally to the fields of proteins, diagnostics, therapeutics and nutrition. More particularly, the present invention provides an isolated protein molecule in or related to the tumour necrosis factor (TNF) superfamily such as TNF-a, Lymphotoxin-a (LT-a), TNFRI, TNFRII, OX40, BAFF, NGFR, Fas Ligand or chimeric molecules thereof comprising at least a portion of the protein molecule, such as TNF-a-Fc, LT-a-Fc, TNFRI-Fc, TNFRII-Fc, OX40-Fc, BAFF-Fc, NGFR-Fc, Fas Ligand-Fc; wherein the protein or chimeric molecule thereof has a profile of measurable physiochemical parameters, wherein the profile is indicative of, associated with or forms the basis of one or more pharmacological traits. The present invention further contemplates the use of the isolated protein or chimeric molecule thereof in a range of diagnostic, prophylactic, therapeutic, nutritional and/or research applications.

Abstract translation: 本发明一般涉及蛋白质，诊断学，治疗学和营养领域。 更具体地，本发明提供了在肿瘤坏死因子（TNF）超家族中或与肿瘤坏死因子（TNF）a，Lymphotoxin-a（LT-a），TNFRI，TNFRII，OX40，BAFF，NGFR，Fas配体 或其嵌合分子，其包含蛋白质分子的至少一部分，例如TNF-α-Fc，LT-α-Fc，TNFRI-Fc，TNFRII-Fc，OX40-Fc，BAFF-Fc，NGFR-Fc，Fas配体 -fc; 其中所述蛋白质或其嵌合分子具有可测量的生理化学参数的轮廓，其中所述轮廓指示，与一个或多个药理学性状的基础相关联或形成其基础。 本发明进一步考虑了在诊断，预防，治疗，营养和/或研究应用范围内使用分离的蛋白质或其嵌合分子。