公开(公告)号：WO2018191879A1

公开(公告)日：2018-10-25

申请号：PCT/CN2017/081048

申请日：2017-04-19

Applicant: EBAY INC. ,  LIU, Kang

Inventor： LIU, Kang ,  POUNDS, Jennica Jane ,  ROGERS, Aidan ,  PUGACH, Stanislav

IPC: G06F9/44

CPC classification number: G06F16/24568 ,  G06F16/23 ,  G06F16/2477

Abstract: Aspects of the present disclosure include a system comprising a machine-readable storage medium storing instructions and computer-implemented methods for consistency mitigation in real-time streams. Consistent with some embodiments, the method includes reading a message object from a message queue and adding the message object to an aggregating cache. The aggregating cache includes a linked list of ordered message objects. The method further includes applying an aggregating function to the message objects in the linked list and persisting the aggregated message objects to a database. The method further includes clearing the message objects from the aggregating cache based on the message objects being persisted to the database.

公开(公告)号：WO2007035717A3

公开(公告)日：2007-03-29

申请号：PCT/US2006/036454

申请日：2006-09-18

Applicant: THE ROCKEFELLER UNIVERSITY ,  STEINMAN, Ralph, M. ,  LIU, Kang ,  TSUJI, Moriya

Inventor： STEINMAN, Ralph, M. ,  LIU, Kang ,  TSUJI, Moriya

IPC: C07H13/00

Abstract: This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.

公开(公告)号：WO2007035717A2

公开(公告)日：2007-03-29

申请号：PCT/US2006036454

申请日：2006-09-18

Applicant: UNIV ROCKEFELLER ,  STEINMAN RALPH M ,  LIU KANG ,  TSUJI MORIYA

Inventor： STEINMAN RALPH M ,  LIU KANG ,  TSUJI MORIYA

IPC: A61K31/739

CPC classification number: A61K31/739

Abstract: This invention relates to immunogenic compounds which may serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.

Abstract translation: 本发明涉及可用作NKT（天然杀伤T）细胞的配体的免疫原性化合物及其用于调节免疫应答的方法。

公开(公告)号：WO9938952A3

公开(公告)日：1999-10-14

申请号：PCT/US9902006

申请日：1999-01-29

Applicant: ADVANCED TISSUE SCIENCES INC ,  MANSBRIDGE JONATHAN N ,  LIU KANG

Inventor： MANSBRIDGE JONATHAN N ,  LIU KANG

IPC: A61K35/12 ,  A61K48/00 ,  A61L27/22 ,  A61L27/38 ,  C12N5/00 ,  A61L27/00 ,  C12N5/10 ,  C12P21/00

CPC classification number: A61L27/3886 ,  A61K35/12 ,  A61K48/00 ,  A61L27/22 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/3895 ,  C12N5/0068 ,  C12N2502/1323 ,  C12N2533/30 ,  C12N2533/90

Abstract: The invention relates to cells or tissues having an increased amount of regulatory proteins, including cytokines, growth factors, angiogenic factors and/or stress proteins, and methods of producing and using those cells or tissues. The invention is based on the discovery that the production of regulatory proteins is induced in cells or tissue constructs following cryopreservation and subsequent thawing of the cells or constructs. The compositions and methods of this invention are useful for the treatment of wound healing and the repair and/or regeneration of other tissue defects including those of skin, cartillage, bone, and vascular tissue as well as for enhancing the culture and/or differentiation of cells and tissues in vitro .

Abstract translation: 本发明涉及具有增加量的调节蛋白的细胞或组织，包括细胞因子，生长因子，血管发生因子和/或应激蛋白，以及产生和使用这些细胞或组织的方法。 本发明基于以下发现：在冷冻保存和随后的细胞或构建体解冻之后，在细胞或组织构建体中诱导调节蛋白的产生。 本发明的组合物和方法可用于治疗伤口愈合和修复和/或再生包括皮肤，软组织，骨骼和血管组织在内的其它组织缺陷，以及用于增强培养和/或分化 细胞和组织在体外。