公开(公告)号：WO2013141695A1

公开(公告)日：2013-09-26

申请号：PCT/NL2012/050179

申请日：2012-03-22

Applicant: UNIVERSITEIT TWENTE ,  UNIVERSIDAD DE SEVILLA ,  VAN HOEVE, Willem ,  DE CASTRO HERNÁNDEZ, Elena ,  GORDILLO ARIAS DE SAVEEDRA, José, Manuel ,  VERSLUIS, Andreas, Michael ,  LOHSE, Detlof

Inventor： VAN HOEVE, Willem ,  DE CASTRO HERNÁNDEZ, Elena ,  GORDILLO ARIAS DE SAVEEDRA, José, Manuel ,  VERSLUIS, Andreas, Michael ,  LOHSE, Detlof

IPC: B01J19/00 ,  B01F13/00

CPC classification number: B01F5/0602 ,  A61K49/223 ,  B01F3/0446 ,  B01F3/04985 ,  B01F13/0062 ,  B01F13/0064 ,  B01F13/0084 ,  B01F13/0086 ,  B01F2003/04858 ,  B01F2005/0097 ,  B01F2215/0034 ,  B01J19/0093 ,  B01J2219/0084 ,  B01J2219/0086 ,  B01J2219/00894 ,  B01J2219/00959 ,  B01J2219/00995

Abstract: An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

Abstract translation: 一种用于批量生产单分散微泡的装置（1），包括微流体聚焦装置（2），该微流体聚焦装置包括分散相流体供应通道（110），该分散相流体供应通道具有排出流入聚焦结（140）的出口（114）。 连续相流体供应通道（120,120'）具有排出到流动聚焦结的出口（124）; 和具有设置在流动聚焦结处的入口（132）的气泡形成通道（130）。 流动聚焦结（140）的构造使得在操作中，从分散相流体供应通道（110）的出口（114）排出的分散相流体（12）的流动可通过 在至少一个连续相流体供应通道的出口处的连续相流体的聚焦流动形成逐渐变薄的分散相流体的喷射，其延伸到气泡形成通道的入口。

公开(公告)号：WO2013141695A8

公开(公告)日：2014-10-16

申请号：PCT/NL2012050179

申请日：2012-03-22

Applicant: UNIV TWENTE ,  UNIV SEVILLA ,  VAN HOEVE WILLEM ,  DE CASTRO HERNÁNDEZ ELENA ,  GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL ,  VERSLUIS ANDREAS MICHAEL ,  LOHSE DETLOF

Inventor： VAN HOEVE WILLEM ,  DE CASTRO HERNÁNDEZ ELENA ,  GORDILLO ARIAS DE SAVEEDRA JOSÉ MANUEL ,  VERSLUIS ANDREAS MICHAEL ,  LOHSE DETLOF

IPC: B01J19/00 ,  B01F13/00

CPC classification number: B01F5/0602 ,  A61K49/223 ,  B01F3/0446 ,  B01F3/04985 ,  B01F13/0062 ,  B01F13/0064 ,  B01F13/0084 ,  B01F13/0086 ,  B01F2003/04858 ,  B01F2005/0097 ,  B01F2215/0034 ,  B01J19/0093 ,  B01J2219/0084 ,  B01J2219/0086 ,  B01J2219/00894 ,  B01J2219/00959 ,  B01J2219/00995

Abstract: An apparatus (1) for mass producing monodisperse microbubbles, comprising a microfluidic flow focusing device (2) including a dispersed phase fluid supply channel (110) having an outlet (114) that discharges into a flow focusing junction (140); a continuous phase fluid supply channel (120, 120') having an outlet (124) that discharges into the flow focusing junction; and a bubble formation channel (130) having an inlet (132) disposed at the flow focusing junction. The configuration of the flow focusing junction (140) is such that, in operation, a flow of dispersed phase fluid (12) discharging from the outlet (114) of the dispersed phase fluid supply channel (110) is engageable in co-flow by a focusing flow of continuous phase fluid discharging from the outlet of the at least one continuous phase fluid supply channel under formation of a gradually thinning jet of dispersed phase fluid that extends into the inlet of the bubble formation channel.

Abstract translation: 一种用于批量生产单分散微泡的装置（1），包括微流体聚焦装置（2），该微流体聚焦装置包括分散相流体供应通道（110），该分散相流体供应通道具有排出流入聚焦结（140）的出口（114）。 连续相流体供应通道（120,120'）具有排出到流动聚焦结的出口（124）; 和具有设置在流动聚焦结处的入口（132）的气泡形成通道（130）。 流动聚焦结（140）的构造使得在操作中，从分散相流体供应通道（110）的出口（114）排出的分散相流体（12）的流动可通过 在至少一个连续相流体供应通道的出口处的连续相流体的聚焦流动形成逐渐变薄的分散相流体的喷射，其延伸到气泡形成通道的入口。