公开(公告)号：WO2023034819A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075694

申请日：2022-08-30

申请人： MALLINCKRODT ARD IP UNLIMITED COMPANY

发明人： BRIODY, Conor ,  RYAN, Simon ,  MOLONY, Helen ,  O'NEILL, Susan

IPC分类号： A61M5/178 ,  A61M5/31 ,  A61J1/05

摘要： Provided herein is a pre-filled manual apparatus and methods of use thereof. The pre-filled manual apparatus includes a repository corticotropin pharmaceutical composition for an adult patient ≥ 18 years old in need thereof to deliver a one-time use dose only. The manual injector apparatus is capable of being stored at room temperature for up to 24 hours prior to administration and the repository corticotropin pharmaceutical composition is a naturally sourced complex mixture comprising N-25 deamidated porcine ACTH (1-39).