公开(公告)号：WO2004019876A2

公开(公告)日：2004-03-11

申请号：PCT/US2003/026923

申请日：2003-08-28

Applicant: CURIS, INC. ,  WASHINGTON UNIVERSITY IN ST. LOUIS ,  CHARETTE, Marc, F. ,  HRUSKA, Keith, A. ,  MCCARTNEY, John

Inventor： CHARETTE, Marc, F. ,  HRUSKA, Keith, A. ,  MCCARTNEY, John

IPC: A61K

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/401 ,  A61K38/1875 ,  A61K2300/00

Abstract: The present invention provides reagents and methods for the treatment, and pharmaceuticals for use in the prevention and/or treatment, of chronic renal failure and other renal disorders in subjects (particularly mammalian subjects) renal replacement therapy. The methods involve the conjoint administration of ACE (Angiotensin-Converting Enzyme) inhibitors or Angiotensin II Receptor Antagonists (AIIRAs) with one or more OP/BMP family of proteins (morphogens, or inducers of morphogens, or agonists of the corresponding morphogen receptors, etc.). The invention also provides methods for implantation of renal cells induced with the conjoint administration of ACE inhibitors or AIIRAs with those morphogens.

Abstract translation: 本发明提供用于治疗的试剂和方法，以及用于预防和/或治疗受试者（特别是哺乳动物受试者）肾脏替代疗法中的慢性肾功能衰竭和其它肾脏疾病的药物。 该方法涉及ACE（血管紧张素转换酶）抑制剂或血管紧张素II受体拮抗剂（AIIRAs）与一种或多种蛋白质（形态发生物或​​形态发生物诱导剂或相应的形态发生受体的激动剂等）的一个或多个OP / BMP家族 ）。 本发明还提供了用这些形态发生剂联合施用ACE抑制剂或AIIRA诱导的肾细胞植入方法。

公开(公告)号：WO2004019876A3

公开(公告)日：2006-03-23

申请号：PCT/US0326923

申请日：2003-08-28

Applicant: CURIS INC ,  BARNES JEWISH HOSPITAL ,  CHARETTE MARC F ,  HRUSKA KEITH A ,  MCCARTNEY JOHN

Inventor： CHARETTE MARC F ,  HRUSKA KEITH A ,  MCCARTNEY JOHN

IPC: A01N61/00 ,  A01N37/18 ,  A61K31/00 ,  A61K31/401 ,  A61K38/00 ,  A61K38/04 ,  A61K38/17 ,  A61K38/18 ,  A61K45/06 ,  A61P13/00

CPC classification number: A61K45/06 ,  A61K31/00 ,  A61K31/401 ,  A61K38/1875 ,  A61K2300/00

Abstract: The present invention provides reagents and methods for the treatment, and pharmaceuticals for use in the prevention and/or treatment, of chronic renal failure and other renal disorders in subjects (particularly mammalian subjects) renal replacement therapy. The methods involve the conjoint administration of ACE (Angiotensin-Converting Enzyme) inhibitors or Angiotensin II Receptor Antagonists (AIIRAs) with one or more OP/BMP family of proteins (morphogens, or inducers of morphogens, or agonists of the corresponding morphogen receptors, etc.). The invention also provides methods for implantation of renal cells induced with the conjoint administration of ACE inhibitors or AIIRAs with those morphogens.

Abstract translation: 本发明提供用于治疗的试剂和方法，以及用于预防和/或治疗受试者（特别是哺乳动物受试者）肾脏替代疗法中的慢性肾功能衰竭和其它肾脏疾病的药物。 该方法涉及ACE（血管紧张素转换酶）抑制剂或血管紧张素II受体拮抗剂（AIIRAs）与一种或多种蛋白质（形态发生物或​​形态发生物诱导剂或相应的形态发生受体的激动剂等）的一个或多个OP / BMP家族 ）。 本发明还提供了用这些形态发生剂联合施用ACE抑制剂或AIIRA诱导的肾细胞植入方法。

公开(公告)号：WO1998011558A1

公开(公告)日：1998-03-19

申请号：PCT/GB1997002485

申请日：1997-09-15

Applicant: BRITISH NUCLEAR FUELS PLC ,  McCARTNEY, John

Inventor： BRITISH NUCLEAR FUELS PLC

IPC: G21C03/326

CPC classification number: G21C3/326 ,  G21Y2002/501 ,  G21Y2004/303 ,  Y02E30/38

Abstract: The invention is concerned with the minimisation of radiological doses during manufacturing processes of fuel assemblies, by employing non-irradiated fuel as a shielding material against the radiological output of re-processed fuel materials. The non-irradiated fuel can be employed in peripheral fuel rods and/or in the end portions of fuel rods with beneficial effects.

Abstract translation: 本发明涉及在燃料组件的制造过程中通过使用未经照射的燃料作为防止重新处理的燃料材料的放射性输出的屏蔽材料的放射剂量的最小化。 未照射的燃料可以用于周边燃料棒和/或燃料棒的端部，具有有益的作用。

公开(公告)号：WO2006063074A3

公开(公告)日：2006-06-15

申请号：PCT/US2005/044311

申请日：2005-12-08

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  ZORNBERG, Jorge ,  MCCARTNEY, John, S.

Inventor： ZORNBERG, Jorge ,  MCCARTNEY, John, S.

IPC: G01N15/08

Abstract: The present invention includes an apparatus, method and centrifuge permeameter system that includes a hydraulic permeameter 70 adapted for use in a centrifuge; and an automated data acquisition system, wherein the centrifuge permeameter 70 non-destructively determines one or more soil characteristics from a sample of granular material such as soil, rock, and concrete when centrifuged.

公开(公告)号：WO2006063074A2

公开(公告)日：2006-06-15

申请号：PCT/US2005044311

申请日：2005-12-08

Applicant: UNIV TEXAS ,  ZORNBERG JORGE ,  MCCARTNEY JOHN S

Inventor： ZORNBERG JORGE ,  MCCARTNEY JOHN S

IPC: G01N15/08

CPC classification number: G01N15/08 ,  G01N15/0826 ,  G01N15/0893

Abstract: The present invention includes an apparatus, method and centrifuge permeameter system that includes a hydraulic permeameter 70 adapted for use in a centrifuge; and an automated data acquisition system, wherein the centrifuge permeameter 70 non-destructively determines one or more soil characteristics from a sample of granular material such as soil, rock, and concrete when centrifuged.

Abstract translation: 本发明包括一种装置，方法和离心渗透仪系统，其包括适于在离心机中使用的液压渗透仪70; 以及自动数据采集系统，其中离心机渗透仪70在离心时非破坏性地确定来自颗粒材料样品（例如土壤，岩石和混凝土）的一种或多种土壤特性。