公开(公告)号：WO2019008593A1

公开(公告)日：2019-01-10

申请号：PCT/IN2017/050433

申请日：2017-09-28

Applicant: MELODY HEALTHCARE PVT. LTD

Inventor： PATEL, Milind

IPC: C07D239/42 ,  C07D405/06

CPC classification number: C07D239/42

Abstract: Disclosed here is a process for the preparation of amorphous Rosuvastatin calcium hydrate with high purity.

公开(公告)号：WO2021033198A1

公开(公告)日：2021-02-25

申请号：PCT/IN2020/050691

申请日：2020-08-05

Applicant: MELODY HEALTHCARE PVT. LTD

Inventor： SINGHANIA, Harshvardhan ,  SINGHANIA, Devang

IPC: A61K31/138

Abstract: The invention discloses an improved process for preparation of Vilanterol or a pharmaceutically acceptable salt thereof with good yields and high purity.

公开(公告)号：WO2014118796A1

公开(公告)日：2014-08-07

申请号：PCT/IN2013/000312

申请日：2013-05-13

Applicant: MELODY HEALTHCARE PVT. LTD.

Inventor： PATEL, Dayabhai Somabhai ,  GHOGARE, Anil Balkrishna ,  VISHE, Kishor Tukaram

IPC: C07D215/18 ,  A61K31/47 ,  A61P11/06

CPC classification number: C07D215/18

Abstract: The present invention disclosed herein is a cost effective, in-situ process for the preparation of montelukast or its pharmaceutically acceptable salts of formula (1) by reacting optically pure (S)-1-{3-[2-(7-chloroquinolin-2-yl)ethylene]-phenyl}-3-[2-(1-hydroxy-1-methyl ethyl) phenyl]-propan-I-ol with methane sulfonyl chloride to afford mesylate derivative of formula (2) substantially free of impurities; followed by insitu condensing the same with disodium salt of mercapto-cyclopropyl acetic acid of formula (3) to afford montelukast free acid in good yield and purity, then converting the montelukast free acid into its substituted amine salt of formula (4). Further the montelukast substituted amine is converted into its pharmaceutically acceptable salt.

Abstract translation: 本文公开的本发明是通过使光学纯的（S）-1- {3- [2-（7-氯喹啉-2-基） 吡啶-2-基）乙烯] - 苯基} -3- [2-（1-羟基-1-甲基乙基）苯基] - 丙-1-醇与甲磺酰氯反应，得到基本上不含杂质的式（2）的甲磺酸酯衍生物 ; 然后将其与式（3）的巯基 - 环丙基乙酸的二钠盐相同地进行缩合，得到良好的产率和纯度的孟鲁司特游离酸，然后将孟鲁司特游离酸转化为式（4）的取代的胺盐。 此外，孟鲁司特胺取代的胺被转化成其药学上可接受的盐。