公开(公告)号：WO2015137965A1

公开(公告)日：2015-09-17

申请号：PCT/US2014/027596

申请日：2014-03-14

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： BAIER, Shawn ,  RATHMACHER, John ,  SEDA, Joceylyn

IPC: A23L1/30 ,  A61K31/19 ,  A61P21/00

CPC classification number: A23L33/10 ,  A61K31/19 ,  A61K31/592 ,  A61K31/593 ,  A61K33/06 ,  A61K33/10 ,  A61K45/06 ,  A61K2300/00

Abstract: Liquids, substantially clear liquids and foodstuffs are described that contain free acid HMB. The liquids, substantially clear liquids and foodstuffs are substantially free of crude fat and may contain soluble proteins, carbohydrates, vitamins, minerals, amino acids, flavorings and other components. The products are shelf-stable and are substantially free of separation, gelation, sedimentation and coagulation.

Abstract translation: 描述了含有游离酸HMB的液体，基本上清澈的液体和食品。 液体，基本上透明的液体和食品基本上不含粗脂肪，并且可含有可溶性蛋白质，碳水化合物，维生素，矿物质，氨基酸，调味剂和其它组分。 产品是稳定的并且基本上没有分离，凝胶化，沉淀和凝结。

公开(公告)号：WO2014040067A1

公开(公告)日：2014-03-13

申请号：PCT/US2013/059039

申请日：2013-09-10

Applicant: METABOLIC TECHNOLOGIES, INC. ,  BAIER, Shawn ,  KOLB, Larry ,  RATHMACHER, John

Inventor： BAIER, Shawn ,  KOLB, Larry ,  RATHMACHER, John

IPC: A61K31/19 ,  A61K31/7076

CPC classification number: A61K31/7076 ,  A61K31/19 ,  A61K2300/00

Abstract: The present invention provides a composition comprising HMB and ATP. Methods of administering HMB and ATP to an animal are also described. HMB and ATP are administered to increase power and strength. The combination of HMB and ATP together has a synergistic effect, which results in a surprising and unexpected level of improvement in power and strength. HMB and ATP are also administered to increase lean body mass and muscle hypertrophy and to prevent typical declines in performance that are characteristic of overreaching.

Abstract translation: 本发明提供包含HMB和ATP的组合物。 还描述了向动物施用HMB和ATP的方法。 施用HMB和ATP以增加功率和强度。 HMB和ATP的组合在一起具有协同效应，这导致了功率和强度的惊人和意想不到的改进。 还施用HMB和ATP以增加瘦体重和肌肉肥大，并且防止作为过量表现的典型的性能下降。

公开(公告)号：WO2020263229A1

公开(公告)日：2020-12-30

申请号：PCT/US2019/038948

申请日：2019-06-25

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： RATHMACHER, John ,  PUPURA, Martin

IPC: A23L33/155 ,  A23L33/00 ,  A61K31/19 ,  A61K31/59 ,  C07C65/00

Abstract: The present invention provides a composition comprising an acidic formulation containing β-hydroxy-β-methylbutyrate (HMB), preferably in the free acid form, Vitamin D and a stabilizing excipient, wherein the Vitamin D is stabilized against degradation.

公开(公告)号：WO2019050967A1

公开(公告)日：2019-03-14

申请号：PCT/US2018/049576

申请日：2018-09-05

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： RATHMACHER, John ,  ABUMRAD, Naji ,  FLYNN, Charles

IPC: A61K31/197 ,  A61K31/353 ,  A61K31/355

Abstract: Methods and compositions for use in treating, attenuating, preventing or improving liver fibrosis in a subject are described. The compounds of the present invention are gamma- ketoaldehyde scavengers.

公开(公告)号：WO2019136249A1

公开(公告)日：2019-07-11

申请号：PCT/US2019/012348

申请日：2019-01-04

Applicant: TEXAS TECH UNIVERSITY OFFICE OF RESEARCH COMMERCIALIZATION ,  METABOLIC TECHNOLOGIES, INC.

Inventor： TINSLEY, Grant ,  RATHMACHER, John ,  PITCHFORD, Lisa

IPC: A61K31/19 ,  A61P3/04

Abstract: The present invention provides a composition comprising H MB and methods of using HMB to mitigate loss of lean body mass, increase fat free mass, improve muscular performance, increase body fat loss and decrease body fat percentage in individuals undergoing intermittent

公开(公告)号：WO2017049093A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/052146

申请日：2016-09-16

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： BAIER, Shawn ,  ABUMRAD, Naji ,  HARRIS, Emily

IPC: A61K31/19 ,  A61K31/00 ,  A61K31/185

CPC classification number: A61K31/19

Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance recovery from soft tissue trauma, including both acute and non-acute soft tissue trauma. Enhanced recovery includes reduced recovery time and enhanced soft tissue healing.

Abstract translation: 本发明提供包含HMB的组合物。 还描述了向动物施用HMB的方法。 施用HMB以增强从软组织创伤的恢复，包括急性和非急性软组织创伤。 增强的恢复包括减少恢复时间和增强的软组织愈合。

公开(公告)号：WO2016196637A1

公开(公告)日：2016-12-08

申请号：PCT/US2016/035273

申请日：2016-06-01

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： RATHMACHER, John ,  ABUMRAD, Naji ,  BAIER, Shawn

IPC: A61P3/04 ,  A61K31/19 ,  A61K31/365 ,  C07C53/126

CPC classification number: A61K31/19

Abstract: The present invention provides a composition comprising HMB. Methods of administering HMB to an animal are also described. HMB is administered to enhance or promote lipolysis, increase adipocyte fat oxidation, induce adipocyte and muscle mitochondrial biogenesis, increase energy expenditure, decrease total body weight and increase body fat loss.

Abstract translation: 本发明提供包含HMB的组合物。 还描述了向动物施用HMB的方法。 施用HMB以增强或促进脂肪分解，增加脂肪细胞脂肪氧化，诱导脂肪细胞和肌肉线粒体生物发生，增加能量消耗，减少总体重并增加体脂肪的损失。

公开(公告)号：WO2011075741A1

公开(公告)日：2011-06-23

申请号：PCT/US2010/061367

申请日：2010-12-20

Applicant: METABOLIC TECHNOLOGIES, INC. ,  RATHMACHER, John ,  FULLER, John ,  BAIER, Shawn ,  NISSEN, Steve ,  ABUMRAD, Naji

Inventor： RATHMACHER, John ,  FULLER, John ,  BAIER, Shawn ,  NISSEN, Steve ,  ABUMRAD, Naji

IPC: A01N37/00 ,  A61K31/19

CPC classification number: A61K31/19

Abstract: A method of administering beta-hydroxy-beta-methylbutyric acid (HMB) is described, and specifically administering HMB-acid to a person such that the administration of free acid HMB results in an increase in effectiveness of HMB over administration of free acid HMB results in an increase in effectiveness of HMB over administration of other forms of HMB, including a calcium salt HMB composition is described. Administration of HMB-acid results in an increase in the peak level of HMB in plasma compared with administration of a similar dose of a calcium salt HMB composition. Administration of HMB-acid results in a faster time to reach peak plasma levels of HMB relative to administration of a similar dosage of a calcium salt HMB composition.

Abstract translation: 描述了施用β-羟基-β-甲基丁酸（HMB）的方法，并且特别地向人施用HMB-酸，使得游离酸HMB的施用导致HMB在施用游离酸HMB结果方面的有效性增加 在HMB施用其他形式的HMB（包括钙盐HMB组合物）的有效性方面的增加。 与给予相似剂量的钙盐HMB组合物相比，施用HMB-酸导致血浆中HMB的峰值水平升高。 相对于给予相似剂量的钙盐HMB组合物，HMB-酸的施用导致更快的时间达到HMB的峰值血浆水平。

公开(公告)号：WO2018075867A1

公开(公告)日：2018-04-26

申请号：PCT/US2017/057549

申请日：2017-10-20

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： HOFFMAN, Jay ,  RATHMACHER, John

IPC: A61K31/19 ,  A61P3/04 ,  A23K1/10

Abstract: The present invention provides a composition comprising HMB and at least one probiotic. Methods of administering HMB and at least one probiotic to an animal are also described. HMB and probiotics are administered to attenuate inflammatory cytokine markers and/or maintain muscle integrity.

Abstract translation: 本发明提供了包含HMB和至少一种益生菌的组合物。 还描述了给动物施用HMB和至少一种益生菌的方法。 施用HMB和益生菌以减轻炎性细胞因子标记和/或维持肌肉完整性。

公开(公告)号：WO2018048932A1

公开(公告)日：2018-03-15

申请号：PCT/US2017/050317

申请日：2017-09-06

Applicant: METABOLIC TECHNOLOGIES, INC.

Inventor： RATHMACHER, John ,  ABUMRAD, Naji ,  FLYNN, Charles

IPC: C07C217/58 ,  C07C215/50

Abstract: Methods and compositions for use in treating, preventing or improving diseases related to the liver in an animal, including but not limited to nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD) or nonalcoholic steatohepatitis (NASH), are described. The compounds of the present invention are gamma-ketoaldehyde scavengers.

Abstract translation: 用于治疗，预防或改善动物肝脏相关疾病的方法和组合物，所述疾病包括但不限于非酒精性脂肪肝病（NAFLD），酒精性肝病（ALD）或非酒精性脂肪性肝炎 （NASH）。 本发明的化合物是γ-酮醛清除剂。