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公开(公告)号：WO2009150257A2
公开(公告)日：2009-12-17
申请号：PCT/EP2009059749
申请日：2009-07-28
申请人： POLICHEM SA , MAILLAND FEDERICO , MURA EMANUELA
发明人： MAILLAND FEDERICO , MURA EMANUELA
IPC分类号： A61K31/194 , A61K9/00 , A61K31/20 , A61K31/23 , A61K31/722 , A61K45/06 , A61K47/12 , A61K47/36 , A61P7/00
CPC分类号： A61K45/06 , A61K8/362 , A61K8/37 , A61K8/42 , A61K8/736 , A61K9/0014 , A61K31/16 , A61K31/194 , A61K31/20 , A61K31/23 , A61K31/722 , A61K47/10 , A61K47/14 , A61K47/183 , A61K47/24 , A61K47/36 , A61K47/42 , A61Q19/00 , A61K2300/00
摘要： The present invention is directed to compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, and a short- medium chain dicarboxylic acid amide, or a physiologically acceptable salt thereof, forming a film after application onto the skin, useful for protecting skin of the face and of other affected areas in couperose, rosacea and teleangectasia of the legs.
摘要翻译： 本发明涉及含有壳聚糖，壳聚糖衍生物或其生理学上可接受的盐的组合物，以及短期中链链二羧酸酰胺或其生理学上可接受的盐，其在施用于皮肤上之后形成膜，用于保护皮肤 面部和其他受影响的区域的双耳，红斑痤疮和腿部的电光阴影。
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公开(公告)号：WO2011134669A1
公开(公告)日：2011-11-03
申请号：PCT/EP2011/002153
申请日：2011-04-29
CPC分类号： A61K47/544
摘要： Provided in some embodiments are methods for inducing an antigen-specific immune response in a subject, comprising administering a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X 2 is a bond or linker, X 3 is -P0 4 -, and X 1 , R 1 , R 2 , R 3 , and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
摘要翻译： 在一些实施方案中提供了在受试者中诱导抗原特异性免疫应答的方法，包括施用具有式A或式B结构的化合物：或其药学上可接受的盐，互变异构体或水合物，其中X 2是一个或多个 接头，X3是-P04-，X1，R1，R2，R3和n如本文所述。 在一些实施方案中还提供了制备和使用这些化合物和组合物的方法。
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公开(公告)号：WO2011134668A1
公开(公告)日：2011-11-03
申请号：PCT/EP2011/002152
申请日：2011-04-29
CPC分类号： C07F9/65616 , A61K31/522 , A61K31/685 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/39 , A61K47/544 , A61K2039/55511 , Y02A50/386
摘要： Provided in some embodiments are compositions comprising a compound having a structure according to Formula A or Formula B: or a pharmaceutically acceptable salt, tautomer or hydrate thereof, where X 2 is a bond or linker, X 3 is bond or -PO 4 -, and X 1 , R 1 , R 2 , R 3 , and n are described herein. Also provided in some embodiments are methods for making and using such compounds and compositions.
摘要翻译： 在一些实施方案中提供了包含具有式A或式B结构的化合物或其药学上可接受的盐，互变异构体或水合物的组合物，其中X 2为键或连接基，X 3为键或-PO 4 - ，且X 1， R1，R2，R3和n在本文中描述。 在一些实施方案中还提供了制备和使用这些化合物和组合物的方法。
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4.发明申请
公开(公告)号：WO2010015556A1
公开(公告)日：2010-02-11
申请号：PCT/EP2009/059807
申请日：2009-07-29
申请人： POLICHEM SA , MAILLAND, Federico , MURA, Emanuela
发明人： MAILLAND, Federico , MURA, Emanuela
IPC分类号： A61K31/722 , A61K47/36 , A61K31/506 , A61K31/56 , A61K31/585
CPC分类号： A61K9/0014 , A61K8/342 , A61K8/494 , A61K8/4973 , A61K8/63 , A61K8/736 , A61K8/97 , A61K47/36 , A61Q5/00 , A61Q7/00
摘要： The present invention is directed to liquid compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, forming a film after application onto the scalp and/or the hair, useful for delivery of actives onto the scalp surface and on the hair.
摘要翻译： 本发明涉及含有壳聚糖，壳聚糖衍生物或其生理上可接受的盐的液体组合物，其在施用到头皮和/或头发上后形成膜，其用于将活性物质递送到头皮表面和头发上。
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公开(公告)号：WO2008017521A2
公开(公告)日：2008-02-14
申请号：PCT/EP2007/053793
申请日：2007-04-18
IPC分类号： A61K31/095 , A61K31/198 , A61K31/23 , A61K31/426 , A61P15/02 , A61P17/16 , A61K9/00
CPC分类号： A61K9/0034 , A61K31/095 , A61K31/198 , A61K31/23 , A61K31/426 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/44 , A61K2300/00
摘要： Compositions for improving the elasticity of the vagina and of the perineum during the last trimester of pregnancy, include combining a thiolated compound or mixture thereof with an ester of organic acid or mixture thereof . The compositions according to the present invention improve the elastic properties of the vaginal and/or perineal tissues in terms both of increased extensibility and faster elastic recovery. The compositions according to the present invention may decrease risk of trauma of perineal tissues during delivery, as well as risk of rectal or bladder incontinence as a post-partum short/medium/long term complication.
摘要翻译： 用于改善怀孕最后三个月阴道和会阴的弹性的组合物包括将硫醇化合物或其混合物与有机酸或其混合物的酯组合。 根据本发明的组合物以增加的延展性和更快的弹性恢复方面改善阴道和/或会阴组织的弹性性质。 根据本发明的组合物可以降低分娩期间会阴组织的创伤风险，以及作为产后短/中/长期并发症的直肠或膀胱失禁的风险。
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6.发明申请MODIFIED RELEASE EMULSIONS FOR APPLICATION TO SKIN OR VAGINAL MUCOSA 审中-公开改性释放乳剂用于皮肤或VAGINAL MUCOSA
公开(公告)号：WO2010040632A1
公开(公告)日：2010-04-15
申请号：PCT/EP2009/062190
申请日：2009-09-21
IPC分类号： A61K9/00 , A61K9/06 , A61K9/107 , A61K31/345 , A61K31/4164 , A61K31/4174 , A61K31/4412 , A61K31/4418 , A61K31/4745 , A61K31/522 , A61K31/569 , A61P15/02 , A61P15/12 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/0034 , A61K9/06 , A61K9/107
摘要： Modified release oil in water emulsions that delivers drugs to a target tissue. The emulsions according to the present invention contain the lipophilic active ingredient completely dissolved into the hydrophobic internal phase stabilised by a polymeric surfactant. The presence of this polymer around the hydrophobic droplets avoids the migration of the active ingredient into the external hydrophilic phase and, consequently, its re-crystallization.
摘要翻译： 将药物转移至靶组织的改性释放水中的乳液。 根据本发明的乳液含有完全溶解在由聚合物表面活性剂稳定的疏水性内相中的亲脂性活性成分。 这种聚合物在疏水液滴周围的存在避免了活性成分迁移到外部亲水相中，并因此重新结晶。
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公开(公告)号：WO2009150257A3
公开(公告)日：2009-12-17
申请号：PCT/EP2009/059749
申请日：2009-07-28
申请人： POLICHEM SA , MAILLAND, Federico , MURA, Emanuela
发明人： MAILLAND, Federico , MURA, Emanuela
IPC分类号： A61K31/194 , A61K31/20 , A61K31/23 , A61K31/722 , A61K45/06 , A61P7/00 , A61K47/12 , A61K47/36 , A61K9/00
摘要： The present invention is directed to compositions containing chitosan, a chitosan derivative or a physiologically acceptable salt thereof, and a short- medium chain dicarboxylic acid amide, or a physiologically acceptable salt thereof, forming a film after application onto the skin, useful for protecting skin of the face and of other affected areas in couperose, rosacea and teleangectasia of the legs.
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公开(公告)号：WO2008017521A3
公开(公告)日：2008-05-22
申请号：PCT/EP2007053793
申请日：2007-04-18
IPC分类号： A61K31/095 , A61K9/00 , A61K31/198 , A61K31/23 , A61K31/426 , A61P15/02 , A61P17/16
CPC分类号： A61K9/0034 , A61K31/095 , A61K31/198 , A61K31/23 , A61K31/426 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/44 , A61K2300/00
摘要： Compositions for improving the elasticity of the vagina and of the perineum during the last trimester of pregnancy, include combining a thiolated compound or mixture thereof with an ester of organic acid or mixture thereof . The compositions according to the present invention improve the elastic properties of the vaginal and/or perineal tissues in terms both of increased extensibility and faster elastic recovery. The compositions according to the present invention may decrease risk of trauma of perineal tissues during delivery, as well as risk of rectal or bladder incontinence as a post-partum short/medium/long term complication.
摘要翻译： 用于改善妊娠末三个月期间阴道和会阴弹性的组合物包括将硫醇化化合物或其混合物与有机酸酯或其混合物组合。 根据本发明的组合物在提高延展性和更快的弹性恢复方面改善了阴道和/或会阴组织的弹性性能。 根据本发明的组合物可降低分娩期间会阴组织的创伤风险，以及作为产后短/中/长期并发症的直肠或膀胱失禁的风险。
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