公开(公告)号：WO2019055719A1

公开(公告)日：2019-03-21

申请号：PCT/US2018/050974

申请日：2018-09-13

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NUVU, LLC

Inventor： GOSSMAN, Nir ,  WANG, David ,  BOYDEN, Edward S.

IPC: A61M21/00

CPC classification number: A61M21/00 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2021/0055 ,  A61M2205/3375 ,  A61M2205/3561 ,  A61M2205/50 ,  A61M2205/52 ,  A61M2230/06 ,  A61M2230/10 ,  A61M2230/14 ,  A61M2230/42 ,  A61M2230/63

Abstract: A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

公开(公告)号：WO2020055445A1

公开(公告)日：2020-03-19

申请号：PCT/US2018/067425

申请日：2018-12-22

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NUVU, LLC

Inventor： GROSSMAN, Nir ,  WANG, David ,  BOYDEN, Edward

IPC: A61B5/0476

Abstract: A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint- corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

公开(公告)号：WO2017015428A1

公开(公告)日：2017-01-26

申请号：PCT/US2016/043259

申请日：2016-07-21

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  NUVU LLC

Inventor： GROSSMAN, Nir ,  WANG, David ,  BOYDEN, Edward, S.

IPC: G06F17/14 ,  A61B5/0476 ,  A61B5/00

CPC classification number: A61B5/4836 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/1101 ,  A61B5/4082 ,  A61B5/486 ,  A61B5/6868 ,  A61B5/725 ,  A61B5/7253 ,  A61B5/7257 ,  A61N5/0622 ,  A61N7/00 ,  A61N2005/063 ,  A61N2007/0021 ,  G06F17/14

Abstract: A neuromodulator accurately measures - in real time and over a range of frequencies - the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

Abstract translation: 神经调节器可以准确地测量实时和超过一定范围的频率 - 自然信号的瞬时相位和幅度。 例如，天然信号可以是由神经组织产生的电信号，或诸如肌肉震颤的运动。 神经调节器产生相对于自然信号的相位精确定时的信号。 例如，神经调节器可以产生与自然信号锁相的外生信号。 或者，例如，神经调节器可以产生包括仅在振荡自然信号的每个周期的窄相位范围内发生的短脉冲串的外部信号。 神经调节器纠正吉布斯现象造成的扭曲。 在某些情况下，在进行离散傅里叶逆变换之前，神经调节器通过在频域中对离散傅立叶变换应用因果滤波器来实现。