公开(公告)号：WO2007014392A3

公开(公告)日：2007-06-21

申请号：PCT/US2006029821

申请日：2006-07-28

Applicant: ISP INVESTMENTS INC ,  OLSEN STEPHEN ,  DONEY JOHN ALFRED ,  SHORES CHRISTOPHEN STEVEN

Inventor： OLSEN STEPHEN ,  DONEY JOHN ALFRED ,  SHORES CHRISTOPHEN STEVEN

IPC: A61K9/16 ,  A61K9/26 ,  A61K9/36 ,  A61K9/48 ,  A61K31/122 ,  A61P9/00

CPC classification number: A61K31/122 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K31/12

Abstract: Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q10. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising benzoquinone, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous benzoquinone. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.

Abstract translation: 描述了具有增强的溶解性和生物利用度的苯醌组合物，其含有至少一种具有至少一种溶解度增强聚合物的苯醌。 在一个实施方案中，苯醌是辅酶Q10。 生产生物增强产品的描述方法包括干混和溶剂喷雾干燥。 该方法的一个方面包括提供包含苯醌，溶解度增强聚合物和溶剂并除去溶剂以形成无定形苯醌的混合物的步骤。 通过本发明的组合物和方法制备的产品包括用于人和动物的药物，营养制品，化妆品和个人护理产品。

公开(公告)号：WO2007014392A2

公开(公告)日：2007-02-01

申请号：PCT/US2006/029821

申请日：2006-07-28

Applicant: ISP INVESTMENTS INC. ,  OLSEN, Stephen ,  DONEY, John, Alfred ,  SHORES, Christophen, Steven

Inventor： OLSEN, Stephen ,  DONEY, John, Alfred ,  SHORES, Christophen, Steven

IPC: A61K9/16 ,  A61K9/26 ,  A61K9/48 ,  A61K9/36

CPC classification number: A61K31/122 ,  A61K9/1635 ,  A61K9/1647 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2866 ,  A61K9/4866 ,  A61K31/12

Abstract: Benzoquinone compositions of enhanced solubility and bioavailability are described that contain at least one benzoquinone with at least one solubility-enhancing polymer. In one embodiment, the benzoquinone is coenzyme Q10. Described methods to produce the bioenhanced products comprise dry blending and solvent spray drying. One aspect of the method includes the steps of providing a mixture comprising benzoquinone, a solubility-enhancing polymer and a solvent and removing the solvent to form amorphous benzoquinone. Products made by the invention's compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.

Abstract translation: 描述了增强溶解度和生物利用度的苯醌组合物，其含有至少一种具有至少一种增溶聚合物的苯醌。 在一个实施方案中，苯醌是辅酶Q10。 所描述的生产生物强化产品的方法包括干混和溶剂喷雾干燥。 该方法的一个方面包括以下步骤：提供包含苯醌，增溶溶解聚合物和溶剂的混合物，并除去溶剂以形成无定形苯醌。 由本发明的组合物和方法制造的产品包括用于人和动物的药物，营养品，化妆品和个人护理产品。