公开(公告)号：WO1995009630A1

公开(公告)日：1995-04-13

申请号：PCT/US1994011230

申请日：1994-10-03

Applicant: THE STATE OF OREGON acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION on behalf of OREGON STATE UNIVERSITY

Inventor： THE STATE OF OREGON acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION on behalf of OREGON STATE UNIVERSITY ,  GERWICK, William, H. ,  PROTEAU, Philip, J. ,  NAGLE, Dale, G.

IPC: A61K31/425

CPC classification number: C07D277/10

Abstract: Cytotoxic compounds isolated and purified from a marine cyanobacterium Lyngbya majuscula are disclosed. The specific compounds are termed "Curacin A", "Curacin B", and "Curacin C" along with semi-synthetic isomers and variants termed "Curacin D" and "15,16-dihydrocuracin A". The compounds exhibit substantial biological activity against proliferating cells, and appear to be antimitotics. Methods for using the compounds are also disclosed. The active portions of these molecules appear to comprise at least the thiazoline ring and two alkyl groups appended to separate portions of the ring, including a short (C1 - C6) alkyl group, with or without rings or double bonds, and a long (C8 - C22) alkyl group, with or without double bonds or other lipophilic moieties.

Abstract translation: 公开了从海洋蓝绿松鼠大分子分离和纯化的细胞毒性化合物。 特定化合物被称为“Curacin A”，“Curacin B”和“Curacin C”以及称为“Curacin D”和“15,16-二氢胆酸A”的半合成异构体和变体。 该化合物对增殖细胞表现出显着的生物活性，并且似乎是抗虚型药物。 还公开了使用该化合物的方法。 这些分子的活性部分似乎至少包含噻唑啉环和附加到环的分开部分的两个烷基，包括具有或不具有环或双键的短（C 1 -C 6）烷基，以及长（C8 -C 22）烷基，具有或不具有双键或其它亲油部分。

公开(公告)号：WO2022204209A1

公开(公告)日：2022-09-29

申请号：PCT/US2022/021426

申请日：2022-03-22

Applicant: OREGON STATE UNIVERSITY

Inventor： GOULAS, Konstantinos ,  PHUNG, Truc

IPC: C07D307/34 ,  C07D307/42 ,  C07D307/46 ,  C07D307/52 ,  A61K31/341 ,  A61P31/04 ,  A61P31/12

Abstract: Disclosed herein is a method for making a quaternary ammonium salt according to the formula Also disclosed is a method for making the ammonium salts from an oleofuran compound. The compounds are useful as antibacterial and/or antiviral compounds and methods for administering the compounds also are disclosed.

公开(公告)号：WO2021163294A1

公开(公告)日：2021-08-19

申请号：PCT/US2021/017614

申请日：2021-02-11

Applicant: UNIVERSITY OF HOUSTON SYSTEM ,  OREGON STATE UNIVERSITY

Inventor： GRABOW, Lars ,  SONG, Yuying ,  GOULAS, Konstantinos ,  HAZLETT, Melanie ,  EPLING, William

IPC: H01M4/88 ,  H01M4/92 ,  B01J23/44

Abstract: The present disclosure provides a method for preparing a supported metal alloy catalyst for low temperature engine exhaust oxidation without CO or NO inhibition. The catalyst includes bimetallic PdCu alloy deposited on a SiO2 support using the strong electrostatic adsorption method. The PdCu catalyst may be combined with a traditional PGM-based automotive oxidation catalyst in a series or dual-bed configuration. The first stage of the dual-bed system includes the PdCu catalyst, with the primary role of oxidizing CO at low temperature; the PGM-based catalyst in the second stage then oxidizes NO and hydrocarbons in the absence of any CO-inhibition effects.

公开(公告)号：WO2021080613A1

公开(公告)日：2021-04-29

申请号：PCT/US2019/058130

申请日：2019-10-25

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  OREGON STATE UNIVERSITY

Inventor： MOSHER, Daniel ,  CHAMPION, David A. ,  BAY, Brian K. ,  MCKINLEY, Timothy

IPC: G06K9/03

Abstract: According to examples, an apparatus may include a processor and a memory, in which the processor may determine calibration parameters of a first image capture device and a second image capture device. The processor may assemble measurement scenes of images of a calibration surface through application of the determined calibration parameters on the measurement scenes, in which the first image capture device and the second image capture device may have captured the measurement scenes. The processor may also determine whether an error exists in the image of the calibration surface and, based on a determination that an error exists, determine a modification to the assembled measurement scene that results in a reduction in the error. The processor may further store the modification and the modification may be applied to future assembled measurement scenes.

公开(公告)号：WO2021022061A1

公开(公告)日：2021-02-04

申请号：PCT/US2020/044294

申请日：2020-07-30

Applicant: OREGON STATE UNIVERSITY

Inventor： KOLLURI, Siva, Kumar ,  KERKVLIET, Nancy, I. ,  BERNALES, Sebastian ,  CHAKRAVARTY, Jit ,  PUJALA, Brahmam ,  KHAN, Pasha ,  KUMAR, Varun ,  DANODIA, Abhinandan ,  URETA, Gonzalo

IPC: A61K31/416 ,  A61K31/4439 ,  C07D401/04 ,  C07D401/14

Abstract: Small molecule AhR ligands are disclosed. The ligands can induce the differentiation of Tr1 cells to suppress pathogenic immune responses without inducing nonspecific immune suppression. Methods of treatment of autoimmune diseases using the AhR ligands are also disclosed.

公开(公告)号：WO2020106632A1

公开(公告)日：2020-05-28

申请号：PCT/US2019/062037

申请日：2019-11-18

Applicant: OREGON STATE UNIVERSITY

Inventor： LI, Kaichang ,  LI, Anlong

IPC: C09J11/04 ,  C09J11/06 ,  C09J201/00

Abstract: A pressure sensitive adhesive construct comprising: (A) a backing substrate; and (B) a pressure sensitive adhesive composition disposed on the backing substrate, wherein the pressure sensitive adhesive composition includes an ultraviolet radiation-cured polymer made from: (a) at least one epoxidized plant oil, at least one epoxidized animal fat, or a mixture thereof; (b) at least one dicarboxylic acid, at least one polycarboxylic acid, or a mixture thereof; and (c) at least one compound that contains both one carbon-carbon double bond (C=C) and at least one carboxylic acid group.

公开(公告)号：WO2020076985A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/055446

申请日：2019-10-09

Applicant: OREGON STATE UNIVERSITY

Inventor： JI, Xiulei ,  ZHANG, Chong

IPC: H01M10/36 ,  H01M12/08 ,  H01M4/60 ,  H01M4/50 ,  H01M4/58

Abstract: Water-in-salt electrolytes for zinc metal batteries are disclosed. The electrolyte includes a zinc halide. The electrolyte may be a hybrid water-in-salt electrolyte further including an additional metal halide or nonmetal halide. Batteries including the electrolytes are disclosed, as well as devices including the batteries and methods of making the batteries.

公开(公告)号：WO2019182619A1

公开(公告)日：2019-09-26

申请号：PCT/US2018/024186

申请日：2018-03-23

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  OREGON STATE UNIVERSITY

Inventor： MOSHER, Daniel ,  BAY, Brian ,  CHAMPION, David A.

IPC: G06T7/30 ,  B29C64/386

Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine readable instructions that when executed by the processor, cause the processor to determine whether a first surface map includes a dropout, the first surface map being generated using a first image parameter on a first image and a second image. The instructions may also cause the processor to, based on a determination that the first surface map includes a dropout, recover information corresponding to the dropout. The instructions may further cause the processor to generate a recovered surface map using the recovered information and store the recovered surface map.

公开(公告)号：WO2019182617A1

公开(公告)日：2019-09-26

申请号：PCT/US2018/024176

申请日：2018-03-23

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  OREGON STATE UNIVERSITY

Inventor： CHAMPION, David A. ,  MOSHER, Daniel ,  BAY, Brian

IPC: B29C64/393 ,  B29C64/30 ,  B33Y50/02 ,  B33Y40/00

Abstract: According to examples, an apparatus may include a processor and a memory on which are stored machine-readable instructions that when executed by the processor, cause the processor to access a stereoscopic three-dimensional (3D) image of a layer including solidified build material particles. The instructions may also cause the processor to identify an optical property of the solidified build material particles at a location on the layer from the stereoscopic 3D image. The instructions may further cause the processor to determine whether the identified optical property exceeds a predefined threshold and based on a determination that the identified optical property exceeds the predefined threshold, output an indication that the layer includes an optical property that exceeds the predefined threshold.

公开(公告)号：WO2019079201A2

公开(公告)日：2019-04-25

申请号：PCT/US2018/055922

申请日：2018-10-15

Applicant: OREGON STATE UNIVERSITY

Inventor： TARATULA, Oleh ,  ALANI, Adam ,  TARATULA, Olena

IPC: A61K31/409 ,  A61K41/00

Abstract: Embodiments of a composition comprising a photosensitive compound and a polymer nanoparticle are disclosed herein. The composition may further comprise a targeting moiety. In some embodiments, the photosensitive compound is a phthalocyanine or phthalocyanine derivative, such as a naphthalocyanine. Upon irradiation with near infrared light, the composition may be used as a fluorescent imaging agent and/or as a phototherapeutic agent, such as for photodynamic and/or photothermal therapies. In certain embodiments, the composition is used to treat certain cancers.