公开(公告)号：WO1998017818A1

公开(公告)日：1998-04-30

申请号：PCT/FR1997001891

申请日：1997-10-22

Applicant: UNIVERSITE PAUL SABATIER TOULOUSE III ,  SAMAIN, Daniel ,  PEROCHON, Etienne

Inventor： UNIVERSITE PAUL SABATIER TOULOUSE III

IPC: C12N15/88

CPC classification number: A61K9/1271 ,  A61K47/62 ,  A61K47/645 ,  A61K47/6911 ,  A61K48/00

Abstract: The invention concerns an artificial membrane structure analogous to fixed plasmic membranes comprising a solid substrate (61); a functional membrane (63) which does not circumscribe the external medium; and at least one bifunctional fixing compound (62) inserted between the membrane (63) and the substrate (61), co-operating by polyelectrolytic complexing with the substrate (61) and by lyotropic bonds with the membrane (63). The invention also concerns the use of this structure for obtaining a medicine, a particle, a film, its method of preparation and a lipidic polycationic polymer, and its method of preparation, acting as bifunctional compound (62).

Abstract translation: 本发明涉及类似于包含固体基质（61）的固定血浆膜的人造膜结构; 功能膜（63），其不包围外部介质; 以及插入在膜（63）和基板（61）之间的至少一个双功能固定化合物（62），通过与基板（61）的聚电解配合和通过与膜（63）的溶致粘合来协作。 本发明还涉及该结构用于获得药物，颗粒，膜，其制备方法和脂质聚阳离子聚合物的用途及其作为双官能化合物（62）的制备方法。