公开(公告)号：WO2005077967A1

公开(公告)日：2005-08-25

申请号：PCT/CA2005/000195

申请日：2005-02-14

Applicant: THE UNIVERSITY OF BRITISH COLUMBIA ,  PERRIN, David, M. ,  TING, Richard

Inventor： PERRIN, David, M. ,  TING, Richard

IPC: C07H21/04

CPC classification number: A61K51/04 ,  C07B59/004 ,  C07B2200/05 ,  C07D495/04 ,  C07H21/04

Abstract: Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F) m G (R) n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R through said carbon, nitrogen, phosphorus or sulfur atom; G is silicon or boron; m is 2 to 5 and n is 1 to 3 with m + n = 3 to 6 when G is silicon; m is 1 to 3 and n is 1 to 3 with m + n = 3 to 4 when G is boron; and wherein the compound further comprises one or more counterions when the above formula is charged; and wherein at least one F is 18 F.

Abstract translation: 提供正电子发射化合物及其制备方法。 所述化合物具有式（F）m G（R）n，其中每个R是包含至少一个碳，氮，磷或硫原子的基团，并且G通过所述碳，氮，磷或硫原子连接到R; G是硅或硼; m为2〜5，n为1〜3，当G为硅时，m + n = 3〜6。 m为1〜3，n为1〜3，当G为硼时，m + n = 3〜4。 并且其中当上述式被加料时，所述化合物还包含一个或多个抗衡离子; 并且其中至少一个F是18 F。