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公开(公告)号：WO2023079438A1
公开(公告)日：2023-05-11
申请号：PCT/IB2022/060516
申请日：2022-11-01
申请人： PFIZER INC.
IPC分类号： C07K16/22 , C07K14/705 , A61P35/00 , A61K39/395
摘要： Various forms of cancer and other diseases are treated using a medicinal combination of a SIRPαFc to block binding with CD47, and an anti-VEGF agent such as humanized antibody bevacizumab to control vascularization.
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公开(公告)号：WO2023079428A1
公开(公告)日：2023-05-11
申请号：PCT/IB2022/060461
申请日：2022-10-31
申请人： PFIZER INC.
发明人： CHINTHARLAPALLI, Sudhakar Reddy , SEELIGE, Ruth Ingeborg Johanna , URBAN, Stina Lisa , WON, Hae Jung
IPC分类号： A61K31/437 , A61K39/395 , A61K45/06 , A61P35/00
摘要： The present disclosure relates to combination therapies useful for the treatment of cancers. The combination therapy comprises a PD-1 axis binding antagonist, in combination with a Toll-like receptor 7/8 (TLR7/8) agonist or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising such compounds or salts. In one preferred combination therapy, the TLR7/8 agonist is 2-((4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl)methyl)-2-methylpropane-1,3-diol, or a pharmaceutically acceptable salt thereof, and the cancer to be treated is non-muscle invasive bladder cancer.
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公开(公告)号：WO2023002360A1
公开(公告)日：2023-01-26
申请号：PCT/IB2022/056633
申请日：2022-07-19
申请人： PFIZER INC.
发明人： BERCHIELLI, Alfred , CLARK, Wesley Dewitt , COWDREY, Connor James , GOODWIN, Aaron Keith , HARIHARAN, Subramanian , KRISHNASWAMI, Sriram
摘要： This invention relates to solid forms of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, amorphous solid dispersions of (R)-N-(3-fluoro-4-((3-((1-hydroxypropan-2-yl)amino)-1H-pyrazolo[3,4-b]pyridin-4-yl)oxy)phenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, pharmaceutical compositions comprising such amorphous dispersions, and to methods of using such solid forms and pharmaceutical compositions in the treatment of proliferative diseases such as cancer.
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公开(公告)号：WO2022234417A1
公开(公告)日：2022-11-10
申请号：PCT/IB2022/053995
申请日：2022-04-29
申请人： PFIZER INC.
发明人： ALLEN, Pirada Suphaphiphat , BADKAR, Advait Vijay , DARVARI, Ramin , DORMITZER, Philip Ralph , DUDA, Mark , JANSEN, Kathrin Ute , VAN GEEN HOVEN, Christina
IPC分类号： A61K39/12 , A61K9/127 , A61P31/16 , A61K2039/53 , A61K2039/55555 , A61K2039/70 , A61K9/0019 , A61K9/5123 , C12N2760/16134
摘要： The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines comprising polynucleotide molecules encoding one or more influenza antigens, such as hemagglutinin antigens.
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公开(公告)号：WO2022229846A1
公开(公告)日：2022-11-03
申请号：PCT/IB2022/053870
申请日：2022-04-26
申请人： PFIZER INC.
发明人： CHING, Keith Anthony , LIRA, Maruja Elma , MABRY, Mack Harrison , MU, Xinmeng , ROLLINS, Robert Andrew , SCHAER, David Arlen
IPC分类号： A61K31/444 , A61P35/00
摘要： This invention relates to methods for the treatment and selection of subjects having cancer who may benefit from administration of a TGFβr1 inhibitor.
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公开(公告)号：WO2022215002A1
公开(公告)日：2022-10-13
申请号：PCT/IB2022/053227
申请日：2022-04-06
申请人： PFIZER INC.
IPC分类号： C07C209/24 , C07C209/26 , C07C67/29 , C07C69/24 , C07C219/06 , C07C219/12
摘要： The present disclosure provides methods for producing a compound having a chemical formula of Formula I, wherein R1 and R2 are independently a i) linear or branched or cyclic, ii) saturated or unsaturated, and iii) substituted or unsubstituted hydrocarbon group comprising 1 to 30 carbon atoms; R3 is a i') linear or branched or cyclic, ii') saturated or unsaturated, and iii') substituted or unsubstituted hydrocarbon group; and L1, L2 and L3 independently are linkers.
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公开(公告)号：WO2022200982A1
公开(公告)日：2022-09-29
申请号：PCT/IB2022/052536
申请日：2022-03-21
申请人： PFIZER INC. , ASTELLAS PHARMA INC.
IPC分类号： A61K31/4155 , A61K31/4166 , A61K31/4439 , A61K31/5025 , A61K31/58 , A61K45/06 , A61P35/04
摘要： This invention relates to combination therapies comprising talazoparib, or a pharmaceutically acceptable salt thereof, and an anti-androgen, or a pharmaceutically acceptable salt thereof, and associated pharmaceutical compositions, methods of treatment, and pharmaceutical uses for the treatment of metastatic castration-sensitive prostate cancer in subjects identified as having at least one DNA damage repair gene mutation.
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公开(公告)号：WO2022197963A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020807
申请日：2022-03-17
申请人： PFIZER INC. , OPKO BIOLOGICS LTD.
发明人： ALI, Fawziya Karim , ATKINSON, Andrew, Samuel , HERSHKOVITZ, Oren , MCCORMAC, Paul, Brendan , MOSCHCOVICH, Laura , NEIDHARDT, Edith, Anna , SEK, David, Christopher
摘要： The subject matter described herein is directed to pharmaceutical compositions comprising a long-acting recombinant human growth hormone, and their use in growth-related disorders, methods of making, dosage forms, and uses thereof. In another aspect, disclosed herein are methods of treating growth-related disorders by administering the pharmaceutical compositions.
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公开(公告)号：WO2022187392A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018564
申请日：2022-03-02
申请人： SANOFI , PFIZER INC.
发明人： CELANOVIC, Marina , PAUX, Gautier , HOFFMAN, Justin Thomas , ANNEHEIM, Sandrine , CARTOT-COTTON, Sylvaine , COHEN, Patrick , GOSSELIN, Alice
IPC分类号： A61K31/404 , A61K31/44 , A61K31/506
摘要： The present disclosure provides methods of treating breast cancer with a combination of amcenestrant and palbociclib.
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公开(公告)号：WO2022137106A1
公开(公告)日：2022-06-30
申请号：PCT/IB2021/062082
申请日：2021-12-21
申请人： PFIZER INC.
IPC分类号： C07D403/12 , A61K31/415 , A61P35/00
摘要： The invention relates to solid forms of (1R,3S)-3-[3-({[3-(methoxymethyl)-1-methyl-1H-pyrazol-5-yl]carbonyl}amino)-1H-pyrazol-5-yl]cyclopentyl propan-2-ylcarbamate, to pharmaceutical compositions comprising such solid forms, and to use of such solid forms and pharmaceutical compositions for the treatment of cancer.
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