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    ENGINEERED CAS ENDONUCLEASE VARIANTS FOR IMPROVED GENOME EDITING
    4.
    发明申请
    ENGINEERED CAS ENDONUCLEASE VARIANTS FOR IMPROVED GENOME EDITING 审中-公开

    公开(公告)号：WO2022082179A2

    公开(公告)日：2022-04-21

    申请号：PCT/US2021/071839

    申请日：2021-10-13

    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.

    Inventor： ALARCON, Clara ,  GASIOR, Stephen Lawrence ,  HOU, Zhenglin ,  VAN GINKEL, Elizabeth Sommers ,  YOUNG, Joshua K.

    IPC: C12N9/22 ,  C12N15/11 ,  C12N15/82 ,  C12N15/85

    Abstract: Compositions and methods are provided for genome modification of a target sequence in the genome of a cell, using novel engineered Cas endonucleases. The methods and compositions employ a guide polynucleotide/endonuclease system to provide an effective system for modifying or altering target sequences within the genome of a cell or organism. Also provided are novel effectors and endonuclease systems and elements comprising such systems, such as guide polynucleotide/endonuclease systems comprising an endonuclease. Compositions and methods are also provided for guide polynucleotide/endonuclease systems comprising at least one endonuclease, optionally covalently or non-covalently linked to, or assembled with, at least one additional protein subunit, and for compositions and methods for direct delivery of endonucleases as ribonucleotide proteins.

    INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE
    6.
    发明申请
    INSECTICIDAL PROTEINS AND METHODS FOR THEIR USE 审中-公开

    公开(公告)号：WO2022015619A2

    公开(公告)日：2022-01-20

    申请号：PCT/US2021/041215

    申请日：2021-07-12

    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.

    Inventor： BEESON, William T ,  GRIFFIN, Samantha L ,  LARSEN, Cory M ,  MUTTI, Navdeep ,  ORAL, Jarred Kenneth ,  WEI, Jun-Zhi ,  ZHU, Baolong

    IPC: C12N15/82 ,  C07K14/265 ,  C07K14/21 ,  C12N15/8286 ,  C12R2001/38

    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Hemipteran, Lepidopteran, Coleopteran, Dipteran, fungal, and nematode pest populations and for producing compositions with insecticidal activity.

    DONOR DESIGN STRATEGY FOR CRISPR-CAS9 GENOME EDITING
    7.
    发明申请
    DONOR DESIGN STRATEGY FOR CRISPR-CAS9 GENOME EDITING 审中-公开

    公开(公告)号：WO2021016098A1

    公开(公告)日：2021-01-28

    申请号：PCT/US2020/042579

    申请日：2020-07-17

    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.

    Inventor： DAS, Amit ,  KANUGANTI, Satish ,  MOHANTY, Amitabh ,  SVITASHEV, Sergei ,  TAVVA, Venkata S

    IPC: C12N9/22 ,  C12N15/10 ,  C12N15/82

    Abstract: Methods and compositions are provided for the improvement of homology-directed repair of a double strand break in a plant cell, using concatemers of heterologous polynucleotides that are flanked by sequences capable of sequence hybridization with a guide RNA. In some aspects, the double strand break is created by an RNA-guided Cas endonuclease. The homology-directed repair of the double-strand break may include incorporation of a heterologous polynucleotide, for example a gene encoding a trait of agronomic importance. The homology-directed repair of the double-strand break may occur as a result of template-directed repair using a heterologous polynucleotide as a repair template.

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