公开(公告)号：WO2004014900A1

公开(公告)日：2004-02-19

申请号：PCT/US2003/019890

申请日：2003-07-31

Applicant: ELI LILLY AND COMPANY ,  BONJOUKLIAN, Rosanne ,  DE DIEGO GOMEZ, Jose, Eugenio ,  DE DIOS, Alfonso ,  HAMDOUCHI, Chafiq, Hamdouchi ,  LI, Tiechao ,  LOPEZ DE URALDE GARMENDIA, Beatriz ,  VIETH, Michal ,  YORK, Jeremy, Schulenburg ,  DALLY, Robert, Dean ,  DEL PRADO CATALINA, Miriam, Filadelfa ,  JARAMILLO, Carlos ,  MARTIN CABREJAS, Luisa, Maria ,  MONTERO SALGADO, Carlos ,  PLEITE, Sheila ,  SANCHEZ-MARTINEZ, Concepcion ,  SHEPHERD, Timothy, Alan ,  WIKEL, James, Howard

Inventor： BONJOUKLIAN, Rosanne ,  DE DIEGO GOMEZ, Jose, Eugenio ,  DE DIOS, Alfonso ,  HAMDOUCHI, Chafiq, Hamdouchi ,  LI, Tiechao ,  LOPEZ DE URALDE GARMENDIA, Beatriz ,  VIETH, Michal ,  YORK, Jeremy, Schulenburg ,  DALLY, Robert, Dean ,  DEL PRADO CATALINA, Miriam, Filadelfa ,  JARAMILLO, Carlos ,  MARTIN CABREJAS, Luisa, Maria ,  MONTERO SALGADO, Carlos ,  PLEITE, Sheila ,  SANCHEZ-MARTINEZ, Concepcion ,  SHEPHERD, Timothy, Alan ,  WIKEL, James, Howard

IPC: C07D409/14

CPC classification number: C07D403/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D513/04

Abstract: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.

Abstract translation: 本发明提供式I的激酶抑制剂：其中W代表由苯基或噻吩取代的咪唑，恶唑，吡唑，噻唑三唑。 所公开的化合物抑制p-38激酶，并且可用于治疗转移或类风湿性关节炎。