公开(公告)号：WO2003085112A1

公开(公告)日：2003-10-16

申请号：PCT/IB2002/001258

申请日：2002-04-09

Applicant: UNIVERSITÄT BASEL ,  MEYER, Urs, Albert ,  FRASER, David, John ,  KAUFMANN, Michel, R. ,  PODVINEC, Michael ,  ZUMSTEG, Adrian

Inventor： MEYER, Urs, Albert ,  FRASER, David, John ,  KAUFMANN, Michel, R. ,  PODVINEC, Michael ,  ZUMSTEG, Adrian

IPC: C12N15/54

CPC classification number: C12N15/52 ,  C12Q1/6897

Abstract: Nucleic acid sequences mediating chemical compound induced 5-aminolevulinatesynthase gene (ALAS1) expression are disclosed. Said sequences comprise at leasta DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds formodulation of heme and/or P 450 cytochromes synthesis are described.

Abstract translation: 介导介导化合物诱导的5-氨基乙酰硫辛酸合酶基因（ALAS1）表达的核酸序列。 所述序列包含至少一个DR-4结合位点。 此外，描述了用于测试血红素和/或P 450细胞色素合成的化学化合物调节的体外方法。

公开(公告)号：WO2003085113A1

公开(公告)日：2003-10-16

申请号：PCT/IB2003/001414

申请日：2003-04-04

Applicant: UNIVERSITÄT BASEL ,  MEYER, Urs, Albert ,  FRASER, David, John ,  KAUFMANN, Michel, R. ,  PODVINEC, Michael ,  ZUMSTEG, Adrian

Inventor： MEYER, Urs, Albert ,  FRASER, David, John ,  KAUFMANN, Michel, R. ,  PODVINEC, Michael ,  ZUMSTEG, Adrian

IPC: C12N15/54

CPC classification number: C12N15/52 ,  C12Q1/6897

Abstract: Nucleic acid sequences mediating chemical compound induced 5-aminolevulinate synthase gene (ALAS1) expression are disclosed. Said sequences comprise at least a DR-4 binding site. Furthermore, in vitro methods for testing chemical compounds for modulation of heme and/or P 450 cytochromes synthesis are described.

Abstract translation: 介绍介导化合物诱导的5-氨基乙酰丙酸合酶基因（ALAS1）表达的核酸序列。 所述序列至少包含DR-4结合位点。 此外，描述了用于测试化合物用于调节血红素和/或P 450细胞色素合成的体外方法。