公开(公告)号：WO2007136566A3

公开(公告)日：2008-05-08

申请号：PCT/US2007011346

申请日：2007-05-10

Applicant: PRORHYTHM INC ,  WARNKING REINHARD

Inventor： WARNKING REINHARD

IPC: G02B6/12

CPC classification number: A61B17/2202 ,  A61B2017/22024 ,  A61B2017/22051

Abstract: Ablation device including a probe structure 10 having a proximal end 12 and a distal end 14. Probe structure 10 includes a tubular first catheter 16, a tubular second catheter 18 surrounding the first catheter and a tubular guide catheter extending within the first catheter 16. The first catheter 16 carries a cylindrical ultrasonic transducer 20 adjacent its distal end. The transducer 20 is connected to a source of electrical excitation. The ultrasonic waves emitted by the transducer 20 are directed at the heart wall tissue. Once the tissue reaches the target temperature, the electrical excitation is turned on and off to maintain the tissue at the target temperature. Alternatively, the transducer 20 is subjected to continuous excitation at one power level and upon the tissue reaching the target temperature, the power level of the continuous excitation is switched to a second lower power level.

Abstract translation: 消融装置包括具有近端12和远端14的探针结构10.探针结构10包括管状第一导管16，围绕第一导管的管状第二导管18和在第一导管16内延伸的管状引导导管。 第一导管16在其远端附近承载圆柱形超声换能器20。 换能器20连接到电激励源。 由换能器20发射的超声波指向心脏壁组织。 一旦组织达到目标温度，电激发被打开和关闭，以将组织保持在目标温度。 或者，换能器20在一个功率水平下经受连续激发，并且在组织达到目标温度时，连续激发的功率电平被切换到第二较低功率水平。

公开(公告)号：WO2005102199A1

公开(公告)日：2005-11-03

申请号：PCT/US2005/013424

申请日：2005-04-19

Applicant: PRORHYTHM, INC. ,  WARNKING, Reinhard ,  JUNG, Eugene ,  NAKAGAWA, Hiroshi ,  PACHECO, Robert, C.

Inventor： WARNKING, Reinhard ,  JUNG, Eugene ,  NAKAGAWA, Hiroshi ,  PACHECO, Robert, C.

IPC: A61B18/18

CPC classification number: A61B17/2202 ,  A61B2017/00053 ,  A61B2017/22024 ,  A61B2017/22062 ,  A61N7/022

Abstract: A cardiac ablation device, including a steerable catheter (10) and an expandable ablation element (18) incorporating one or more balloons (20, 22) at the distal end of the catheter, has a continuous passageway (28, 30) extending through it from the proximal end of the catheter to the distal side of the expandable ablation element. A probe (72) carrying electrodes is introduced through this passageway and deploys, under the influence of its own resilience, to a structure incorporating a loop (82) which is automatically aligned with the axis of the expandable ablation device, so that minimal manipulation is required to place the sensor probe.

Abstract translation: 包括可导向导管（10）和在导管的远端处结合有一个或多个气球（20,22）的可扩展消融元件（18）的心脏消融装置具有延伸通过其的连续通道（28,30） 从导管的近端到可扩张消融元件的远侧。 携带电极的探针（72）通过该通道被引入并且在其自身弹性的影响下展开到结合环路（82）的结构，环路82自动地与可扩张消融装置的轴线对齐，使得最小的操作是 需要放置传感器探头。

公开(公告)号：WO2004023978B1

公开(公告)日：2004-08-19

申请号：PCT/US0328578

申请日：2003-09-12

Applicant: PRORHYTHM INC

Inventor： LOPATH PATRICK DAVID ,  HARHEN EDWARD PAUL

IPC: A61B18/00 ,  A61B17/22 ,  A61F2/958 ,  A61M25/00 ,  A61N7/02 ,  A61B18/04

CPC classification number: A61M25/10 ,  A61B17/2202 ,  A61B2017/22054 ,  A61B2017/22062 ,  A61M2025/1084 ,  A61N7/02

Abstract: A balloon catheter is provided with rigid engagement elements (260, 270) which move into engagement when the balloon (216) is inflated, so that the engaged elements stiffen the balloon in the inflated condition. When the balloon is deflated, the engagement elements are at least partially disengaged so that the balloon can flex. A stem (274) on one engagement element (270) may project into the adjacent engagement element (260) in the disengaged condition, so that the stem allows the engagement elements to pivot but constrains them to prevent kinking. A stretchable tube (238) may be provided to allow communication through the balloon, and a spring (262, 42) may be provided to elongate the balloon upon deflation.

Abstract translation: 球囊导管设置有刚性接合元件（260,270），当气囊（216）膨胀时，刚性接合元件（260,270）移动成接合，使得接合元件在膨胀状态下使球囊变硬。 当气囊收缩时，接合元件至少部分脱开，使得气囊能够弯曲。 一个接合元件（270）上的杆（274）可以在分离状态下突出到相邻的接合元件（260）中，使得杆允许接合元件枢转但限制它们以防止扭结。 可以提供可拉伸管（238）以允许通过气囊的连通，并且可以提供弹簧（262,42）以在放气时伸长气囊。

公开(公告)号：WO2007136566A2

公开(公告)日：2007-11-29

申请号：PCT/US2007/011346

申请日：2007-05-10

Applicant: PRORHYTHM, INC. ,  WARNKING, Reinhard

Inventor： WARNKING, Reinhard

IPC: G02B6/42

CPC classification number: A61B17/2202 ,  A61B2017/22024 ,  A61B2017/22051

Abstract: Ablation device including a probe structure 10 having a proximal end 12 and a distal end 14. Probe structure 10 includes a tubular first catheter 16, a tubular second catheter 18 surrounding the first catheter and a tubular guide catheter extending within the first catheter 16. The first catheter 16 carries a cylindrical ultrasonic transducer 20 adjacent its distal end. The transducer 20 is connected to a source of electrical excitation. The ultrasonic waves emitted by the transducer 20 are directed at the heart wall tissue. Once the tissue reaches the target temperature, the electrical excitation is turned on and off to maintain the tissue at the target temperature. Alternatively, the transducer 20 is subjected to continuous excitation at one power level and upon the tissue reaching the target temperature, the power level of the continuous excitation is switched to a second lower power level.

Abstract translation: 消融装置包括具有近端12和远端14的探针结构10.探针结构10包括管状第一导管16，围绕第一导管的管状第二导管18和在第一导管16内延伸的管状引导导管。 第一导管16在其远端附近承载圆柱形超声换能器20。 换能器20连接到电激励源。 由换能器20发射的超声波指向心脏壁组织。 一旦组织达到目标温度，电激发被打开和关闭，以将组织保持在目标温度。 或者，换能器20在一个功率水平下经受连续激发，并且在组织达到目标温度时，连续激发的功率电平被切换到第二较低功率水平。

公开(公告)号：WO2006044662A3

公开(公告)日：2006-07-27

申请号：PCT/US2005037020

申请日：2005-10-14

Applicant: PRORHYTHM INC ,  WARNKING REINHARD ,  SINELNIKOV YEGOR

Inventor： WARNKING REINHARD ,  SINELNIKOV YEGOR

IPC: A61B18/04

CPC classification number: A61F7/02 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B17/2202 ,  A61B2017/00243 ,  A61B2017/22024 ,  A61B2017/22051 ,  A61B2017/22058 ,  A61B2017/22069 ,  A61B2090/3782

Abstract: Ablation apparatus such as a catheter (10) carrying an ultrasonic ablation device (20) including an ablation transducer (42) and a balloon reflector structure (22, 24) for directing ultrasonic energy from the ablation transducer into a ring-like ablation region (A) is provided with an imaging ultrasonic transducer (86) mounted on an imaging probe (80) which may be inserted into or through a passageway (18, 65) extending through the catheter and into or through the ablation device to image the ablation region or neighboring regions. Alternatively, the imaging transducer (102, 202) may be mounted within the balloon reflector structure or distal to this structure.

Abstract translation: 消融装置，例如携带包括消融换能器（42）的超声波消融装置（20）的导管（10）和用于将来自消融换能器的超声能量引导到环状消融区域中的气囊反射器结构（22,24） A）设置有安装在成像探针（80）上的成像超声换能器（86），该成像超声换能器可插入或穿过延伸穿过导管的通道（18,65）并进入或穿过消融装置以成像消融区域 或邻近区域。 或者，成像换能器（102,202）可以安装在气球反射器结构内或远离该结构。

公开(公告)号：WO2007013895A3

公开(公告)日：2007-06-28

申请号：PCT/US2006014024

申请日：2006-04-12

Applicant: PRORHYTHM INC ,  SINELNIKOV YEGOR ,  WARKING REINHARD

Inventor： SINELNIKOV YEGOR ,  WARKING REINHARD

IPC: A61N7/00 ,  A61B17/22

CPC classification number: A61B17/2202 ,  A61B17/22029 ,  A61B17/2251 ,  A61B2017/22027

Abstract: A storage unit holds representations of sensor signals which would be received by a set (30) of ultrasonic transducers (32) from an ultrasonic impulse emitter positioned at each of plural points (P) in the frame of reference of the transducer set. An impulse may be applied at a particular point by using the representation associated with that point to generate an actuation signal corresponding to a time-reversed version of the sensor signal. Impulses may be applied in a pattern (150) by using those representations associated with points in the pattern to generate actuation signals and applying those signals to the transducer set. By placing the transducer set in a known spatial relationship to the a body structure such as heart, an ablation pattern may be formed in a desired relationship to the body structure, such as around the ostium of a pulmonary vein.

Abstract translation: 存储单元保持传感器信号的表示，所述传感器信号将由位于换能器组的参考系中的多个点（P）中的每一个处的超声波脉冲发射器的组（30）超声波换能器（32）接收。 可以通过使用与该点相关联的表示在特定点处施加脉冲以产生对应于传感器信号的时间反转版本的致动信号。 可以通过使用与图案中的点相关联的那些表示来以图案（150）来施加脉冲以产生致动信号并将这些信号应用于换能器组。 通过将已知空间关系的换能器组置于诸如心脏的身体结构上，可以以与身体结构（例如肺静脉口）周围的所需关系形成消融图案。

公开(公告)号：WO2006130435A3

公开(公告)日：2007-03-29

申请号：PCT/US2006020295

申请日：2006-05-24

Applicant: PRORHYTHM INC ,  SAVAGE JAMES D ,  MERINO JAIME

Inventor： SAVAGE JAMES D ,  MERINO JAIME

IPC: A61M25/00 ,  A61B17/22 ,  A61M25/01

CPC classification number: A61B17/22022 ,  A61B17/2202 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2017/22058 ,  A61M25/0054 ,  A61M25/0136 ,  A61M25/0141 ,  A61M25/0147 ,  A61M2025/015

Abstract: A steerable catheter (10) has a steering portion (14) incorporating a spear cut junction of catheter material, thereby providing for a gradual change in flexibility in the steering portion. A guide tube (42) and spring (44) may be located inside a pull wire lumen (38) of catheter (10), with spring (44) distal to guide tube (42) so that spring (44) is disposed at least partially within steering section. A steering mechanism moves a pull wire (40) linearly in order to steer catheter (10).

Abstract translation: 可操纵的导管（10）具有包括导管材料的矛切割接头的转向部分（14），从而提供转向部分的柔性的逐渐变化。 引导管（42）和弹簧（44）可以位于导管（10）的拉线管腔（38）内部，弹簧（44）远离引导管（42），使得弹簧（44）至少设置 部分在转向部分内。 转向机构线性地移动拉线（40）以便引导导管（10）。

公开(公告)号：WO2006076269A1

公开(公告)日：2006-07-20

申请号：PCT/US2006/000625

申请日：2006-01-10

Applicant: PRORHYTHM, INC. ,  WARNKING, Reinhard

Inventor： WARNKING, Reinhard

IPC: A61N7/02 ,  A61B17/22

CPC classification number: A61B17/320092 ,  A61B17/2202 ,  A61B2017/00243 ,  A61B2017/22024 ,  A61N7/022

Abstract: Apparatus for treating cardiac arrhythmias includes an ultrasonic ablation device incorporating an ultrasonic emitter (22, 400), means (10, 14, 402, 404) for positioning the ablation device outside of the heart but adjacent the epicardial surface of the heart, and means (26, 28, 30) for focusing the ultrasonic energy emitted by the emitter into an ablation region, so that the ablation region is disposed within the wall of the heart.

Abstract translation: 用于治疗心律失常的装置包括：超声波消融装置，其包括超声波发射器（22,400），用于将消融装置定位在心脏外部但邻近心脏心外膜表面的装置（10,14，402,404） （26,28,30），用于将由发射器发射的超声能量聚焦到消融区域中，使得消融区域设置在心脏的壁内。

公开(公告)号：WO2007013895A2

公开(公告)日：2007-02-01

申请号：PCT/US2006/014024

申请日：2006-04-12

Applicant: PRORHYTHM, INC. ,  SINELNIKOV, Yegor ,  WARKING, Reinhard

Inventor： SINELNIKOV, Yegor ,  WARKING, Reinhard

IPC: A61N7/00 ,  A61B17/22

CPC classification number: A61B17/2202 ,  A61B17/22029 ,  A61B17/2251 ,  A61B2017/22027

Abstract: A storage unit holds representations of sensor signals which would be received by a set (30) of ultrasonic transducers (32) from an ultrasonic impulse emitter positioned at each of plural points (P) in the frame of reference of the transducer set. An impulse may be applied at a particular point by using the representation associated with that point to generate an actuation signal corresponding to a time-reversed version of the sensor signal. Impulses may be applied in a pattern (150) by using those representations associated with points in the pattern to generate actuation signals and applying those signals to the transducer set. By placing the transducer set in a known spatial relationship to the a body structure such as heart, an ablation pattern may be formed in a desired relationship to the body structure, such as around the ostium of a pulmonary vein.

Abstract translation: 存储单元保持传感器信号的表示，所述传感器信号将由位于换能器组的参考系中的多个点（P）中的每一个处的超声波脉冲发射器的组（30）超声波换能器（32）接收。 可以通过使用与该点相关联的表示在特定点处施加脉冲以产生对应于传感器信号的时间反转版本的致动信号。 可以通过使用与图案中的点相关联的那些表示来以图案（150）来施加脉冲以产生致动信号并将这些信号应用于换能器组。 通过将已知空间关系的换能器组置于诸如心脏的身体结构上，可以以与身体结构（例如肺静脉口）周围的所需关系形成消融图案。

公开(公告)号：WO2006130435A2

公开(公告)日：2006-12-07

申请号：PCT/US2006/020295

申请日：2006-05-24

Applicant: PRORHYTHM, INC. ,  SAVAGE, James, D. ,  MERINO, Jaime

Inventor： SAVAGE, James, D. ,  MERINO, Jaime

IPC: A61M25/00 ,  A61M25/01 ,  A61B17/22

CPC classification number: A61B17/22022 ,  A61B17/2202 ,  A61B2017/003 ,  A61B2017/22024 ,  A61B2017/22058 ,  A61M25/0054 ,  A61M25/0136 ,  A61M25/0141 ,  A61M25/0147 ,  A61M2025/015

Abstract: A steerable catheter (10) has a steering portion (14) incorporating a spear cut junction of catheter material, thereby providing for a gradual change in flexibility in the steering portion. A guide tube (42) and spring (44) may be located inside a pull wire lumen (38) of catheter (10), with spring (44) distal to guide tube (42) so that spring (44) is disposed at least partially within steering section. A steering mechanism moves a pull wire (40) linearly in order to steer catheter (10).

Abstract translation: 可操纵的导管（10）具有结合导管材料的矛形切割接头的转向部分（14），从而提供转向部分的柔性的逐渐变化。 引导管（42）和弹簧（44）可以位于导管（10）的拉线管腔（38）内部，弹簧（44）远离引导管（42），使得弹簧（44）至少设置 部分在转向部分内。 转向机构线性移动拉线（40）以便引导导管（10）。